Topical Collection "Regulation by Non-Coding RNAs"

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A topical collection in International Journal of Molecular Sciences (ISSN 1422-0067). This collection belongs to the section "Biochemistry, Molecular Biology and Biophysics".

Editor

Collection Editor
Dr. Martin Pichler
Division of Clinical Oncology, Department of Medicine, Medical University of Graz, Auenbruggerplatz 15, Austria
Website: https://forschung.medunigraz.at/fodok/suchen.person_uebersicht?sprache_in=en&ansicht_in=&menue_id_in=101&id_in=2001296
Interests: Non-coding RNAs; MicroRNAs; cancer; Inflammation; Metabolism; Gene expression; cancer stem cells; epithelial-mesenchymal transition

Topical Collection Information

Dear Colleagues,

Non-Coding RNAs are currently a hot research topic in many fields of biology, medicine, and chemistry. It is increasingly clear that non-coding RNAs are involved in fundamentally physiological and pathological processes. These processes touch on many important disciplines, from metabolism to cancer. Non-coding RNAs are regulative: they mainly influence biological processes by regulating other (protein-)coding gene expression. By doing this, the cellular properties of development and growth, stem cell regeneration, apoptosis, authophagy, etc., are strictly controlled by non-coding RNAs. This collection is dedicated to summarizing and highlighting the current research concerning the role of non-coding RNAs in regulating the aforementioned functions. The underlying mechanisms of action, the target molecules, the interactor pairs, and the pertinent cellular functions should all be presented. All relevant fields in medicine (with a special focus on metabolism, cancer, and inflammation) are of interest. The classes of non-coding RNAs should include microRNAs, other small non-coding RNAs, and long non-coding RNAs. Original research articles, review articles, and research letters are welcomed.

Dr. Martin Pichler
Collection Editor

Manuscript Submission Information

Manuscripts for the topical collection can be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on this website. The topical collection considers regular research articles, short communications and review articles. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1600 CHF (Swiss Francs).

Keywords

  • Regulatory RNA
  • sRNA
  • ncRNA
  • lncRNA
  • miRNA
  • siRNA
  • piRNA
  • CRISPR RNA
  • regulatory small RNA fragments

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Published Papers (22 papers)

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2015  ( 13 papers )


2014  ( 9 papers )


2015
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Int. J. Mol. Sci. 2015, 16(7), 16593-16621; doi:10.3390/ijms160716593
Received: 29 May 2015 / Revised: 10 July 2015 / Accepted: 15 July 2015 / Published: 22 July 2015
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Int. J. Mol. Sci. 2015, 16(6), 12773-12790; doi:10.3390/ijms160612773
Received: 17 May 2015 / Revised: 28 May 2015 / Accepted: 29 May 2015 / Published: 5 June 2015
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Int. J. Mol. Sci. 2015, 16(5), 10491-10506; doi:10.3390/ijms160510491
Received: 16 March 2015 / Revised: 22 April 2015 / Accepted: 4 May 2015 / Published: 7 May 2015
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Int. J. Mol. Sci. 2015, 16(5), 9635-9653; doi:10.3390/ijms16059635
Received: 8 January 2015 / Revised: 24 March 2015 / Accepted: 13 April 2015 / Published: 29 April 2015
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Int. J. Mol. Sci. 2015, 16(4), 8555-8568; doi:10.3390/ijms16048555
Received: 26 February 2015 / Revised: 24 March 2015 / Accepted: 26 March 2015 / Published: 16 April 2015
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Int. J. Mol. Sci. 2015, 16(4), 6855-6867; doi:10.3390/ijms16046855
Received: 6 October 2014 / Revised: 10 November 2014 / Accepted: 13 November 2014 / Published: 26 March 2015
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Int. J. Mol. Sci. 2015, 16(3), 5467-5496; doi:10.3390/ijms16035467
Received: 12 December 2014 / Revised: 22 February 2015 / Accepted: 3 March 2015 / Published: 10 March 2015
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Int. J. Mol. Sci. 2015, 16(3), 4947-4972; doi:10.3390/ijms16034947
Received: 23 December 2014 / Revised: 17 February 2015 / Accepted: 17 February 2015 / Published: 4 March 2015
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Int. J. Mol. Sci. 2015, 16(2), 3251-3266; doi:10.3390/ijms16023251
Received: 17 November 2014 / Accepted: 22 January 2015 / Published: 3 February 2015
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Int. J. Mol. Sci. 2015, 16(1), 1395-1405; doi:10.3390/ijms16011395
Received: 16 December 2014 / Accepted: 30 December 2014 / Published: 8 January 2015
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Int. J. Mol. Sci. 2015, 16(1), 1448-1465; doi:10.3390/ijms16011448
Received: 1 December 2014 / Accepted: 30 December 2014 / Published: 8 January 2015
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Int. J. Mol. Sci. 2015, 16(1), 1466-1481; doi:10.3390/ijms16011466
Received: 31 October 2014 / Accepted: 5 January 2015 / Published: 8 January 2015
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Int. J. Mol. Sci. 2015, 16(1), 1192-1208; doi:10.3390/ijms16011192
Received: 22 November 2014 / Accepted: 26 December 2014 / Published: 6 January 2015
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2014
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Int. J. Mol. Sci. 2014, 15(11), 21554-21586; doi:10.3390/ijms151121554
Received: 19 September 2014 / Revised: 7 November 2014 / Accepted: 8 November 2014 / Published: 24 November 2014
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Int. J. Mol. Sci. 2014, 15(11), 20434-20448; doi:10.3390/ijms151120434
Received: 17 September 2014 / Revised: 30 October 2014 / Accepted: 30 October 2014 / Published: 7 November 2014
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Int. J. Mol. Sci. 2014, 15(11), 20266-20289; doi:10.3390/ijms151120266
Received: 11 August 2014 / Revised: 22 October 2014 / Accepted: 27 October 2014 / Published: 6 November 2014
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Int. J. Mol. Sci. 2014, 15(11), 20134-20157; doi:10.3390/ijms151120134
Received: 29 May 2014 / Revised: 27 August 2014 / Accepted: 27 October 2014 / Published: 5 November 2014
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by , ,  and
Int. J. Mol. Sci. 2014, 15(9), 15891-15911; doi:10.3390/ijms150915891
Received: 11 July 2014 / Revised: 27 August 2014 / Accepted: 27 August 2014 / Published: 9 September 2014
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Int. J. Mol. Sci. 2014, 15(9), 15700-15733; doi:10.3390/ijms150915700
Received: 20 June 2014 / Revised: 5 August 2014 / Accepted: 13 August 2014 / Published: 4 September 2014
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Int. J. Mol. Sci. 2014, 15(8), 14475-14491; doi:10.3390/ijms150814475
Received: 2 July 2014 / Revised: 7 August 2014 / Accepted: 12 August 2014 / Published: 20 August 2014
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Int. J. Mol. Sci. 2014, 15(8), 13993-14013; doi:10.3390/ijms150813993
Received: 30 June 2014 / Revised: 23 July 2014 / Accepted: 5 August 2014 / Published: 12 August 2014
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Int. J. Mol. Sci. 2014, 15(8), 13494-13513; doi:10.3390/ijms150813494
Received: 14 June 2014 / Revised: 14 July 2014 / Accepted: 28 July 2014 / Published: 4 August 2014
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Planned Papers

The below list represents only planned manuscripts. Some of these manuscripts have not been received by the Editorial Office yet. Papers submitted to MDPI journals are subject to peer-review.

Title: MiR-199a and miR-497 Are Associated with Better Overall Survival Due to Increased Chemosensitivity in Diffuse Large B Cell Lymphoma Patients 
Authors: Katharina Troppan, Kerstin Wenzl, Martin Pichler, Beata Pursche, Daniela Schwarzenbacher, Julia Feichtinger, Gerhard G. Thallinger, Christine Beham-Schmid, Peter Neumeister *, Alexander Deutsch *
*contributed equally 
Abstract: Background: Micro-RNAs (miRNAs) are short non-coding single-stranded RNA molecules regulating gene expression at the post-transcriptional level. MiRNAs are involved in cell development, differentiation, apoptosis, and proliferation. MiRNAs can either function as tumor suppressor genes or oncogenes in various important pathways. The expression of specific miRNAs has been identified to correlate with tumor prognosis. Methods: For miRNA expression analysis real-time PCR on 81 samples was performed, including 63 diffuse large B-cell lymphoma (DLBCL, 15 of germinal center B-cell like subtype, 17 non germinal center B-cell, 23 transformed, and 8 unclassified) and 18 controls, including 9 peripheral B-cells, 5 germinal-center B-cells, 4 lymphadenitis samples, and 4 lymphoma cell lines (RI-1, SUDHL4, Karpas, U2932). Expression levels of a panel of 11 miRNAs that have been previously involved in other types of cancer (miR-15b_2, miR-16_1*, miR-16_2, miR-16_2*, miR-27a, miR-27a*, miR-98-1, miR-103a, miR-185, miR-199a, and miR-497) were measured and correlated with clinical data. Furthermore, cell lines, lacking miR-199a and miR-497 expression, were electroporated with the two respective miRNAs and treated with standard immunochemotherapy routinely used in patients with DLBCL, followed by functional analyses including cell count and apoptosis assays. Results: 7 miRNAs (miR-16_1*, miR-16_2*, miR-27a, miR-103, miR-185, miR-199, and miR-497) were statistically significant up-regulated in DLBCL compared to normal germinal cells. However, high expression of miR-497 or miR-199a was associated with better overall survival (p=0.042 and p=0.007). Overexpression of miR-199a and miR-497 led to a statistically significant decrease in viable cells in a dose-dependent fashion after exposure to rituximab and various chemotherapeutics relevant in multi-agent lymphoma therapy. Conclusion: Our data indicate that elevated miR-199a and miR-497 levels are associated with improved survival in aggressive lymphoma patients most likely by modifying drug sensitivity to immunochemotherapy. This functional impairment may serve as a potential novel therapeutic target in future treatment of patients with DLBCL.

Last update: 13 July 2015

Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert