Topical Collection "Regulation by Non-Coding RNAs"

Quicklinks

A topical collection in International Journal of Molecular Sciences (ISSN 1422-0067). This collection belongs to the section "Biochemistry, Molecular Biology and Biophysics".

Editor

Collection Editor
Dr. Martin Pichler
Division of Clinical Oncology, Department of Medicine, Medical University of Graz, Auenbruggerplatz 15, Austria
Website: https://forschung.medunigraz.at/fodok/suchen.person_uebersicht?sprache_in=en&ansicht_in=&menue_id_in=101&id_in=2001296
Interests: Non-coding RNAs; MicroRNAs; cancer; Inflammation; Metabolism; Gene expression; cancer stem cells; epithelial-mesenchymal transition

Topical Collection Information

Dear Colleagues,

Non-Coding RNAs are currently a hot research topic in many fields of biology, medicine, and chemistry. It is increasingly clear that non-coding RNAs are involved in fundamentally physiological and pathological processes. These processes touch on many important disciplines, from metabolism to cancer. Non-coding RNAs are regulative: they mainly influence biological processes by regulating other (protein-)coding gene expression. By doing this, the cellular properties of development and growth, stem cell regeneration, apoptosis, authophagy, etc., are strictly controlled by non-coding RNAs. This collection is dedicated to summarizing and highlighting the current research concerning the role of non-coding RNAs in regulating the aforementioned functions. The underlying mechanisms of action, the target molecules, the interactor pairs, and the pertinent cellular functions should all be presented. All relevant fields in medicine (with a special focus on metabolism, cancer, and inflammation) are of interest. The classes of non-coding RNAs should include microRNAs, other small non-coding RNAs, and long non-coding RNAs. Original research articles, review articles, and research letters are welcomed.

Dr. Martin Pichler
Collection Editor

Manuscript Submission Information

Manuscripts for the topical collection can be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on this website. The topical collection considers regular research articles, short communications and review articles. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1600 CHF (Swiss Francs).

Keywords

  • Regulatory RNA
  • sRNA
  • ncRNA
  • lncRNA
  • miRNA
  • siRNA
  • piRNA
  • CRISPR RNA
  • regulatory small RNA fragments

Related Special Issues

Published Papers (40 papers)

Download All Papers
Sort by:

2016  ( 3 papers )


2015  ( 28 papers )


2014  ( 9 papers )


2016
by , , , , , , , , ,  and
Int. J. Mol. Sci. 2016, 17(2), 156; doi:10.3390/ijms17020156
Received: 30 November 2015 / Revised: 20 January 2016 / Accepted: 21 January 2016 / Published: 26 January 2016
Show/Hide Abstract | PDF Full-text (552 KB) | HTML Full-text | XML Full-text | Supplementary Files
abstract graphic

by , , , , , , , ,  and
Int. J. Mol. Sci. 2016, 17(1), 132; doi:10.3390/ijms17010132
Received: 10 October 2015 / Revised: 18 December 2015 / Accepted: 12 January 2016 / Published: 21 January 2016
Show/Hide Abstract | PDF Full-text (818 KB) | HTML Full-text | XML Full-text
abstract graphic

by , ,  and
Int. J. Mol. Sci. 2016, 17(1), 72; doi:10.3390/ijms17010072
Received: 20 November 2015 / Revised: 21 December 2015 / Accepted: 31 December 2015 / Published: 8 January 2016
Show/Hide Abstract | PDF Full-text (1368 KB) | HTML Full-text | XML Full-text
abstract graphic

2015
by , , ,  and
Int. J. Mol. Sci. 2016, 17(1), 22; doi:10.3390/ijms17010022
Received: 3 November 2015 / Revised: 14 December 2015 / Accepted: 16 December 2015 / Published: 24 December 2015
Show/Hide Abstract | PDF Full-text (3405 KB) | HTML Full-text | XML Full-text | Supplementary Files
abstract graphic

by , , , ,  and
Int. J. Mol. Sci. 2015, 16(12), 30204-30222; doi:10.3390/ijms161226230
Received: 12 November 2015 / Revised: 8 December 2015 / Accepted: 9 December 2015 / Published: 18 December 2015
Show/Hide Abstract | PDF Full-text (4753 KB) | HTML Full-text | XML Full-text
abstract graphic

by  and
Int. J. Mol. Sci. 2015, 16(12), 29797-29814; doi:10.3390/ijms161226194
Received: 16 November 2015 / Revised: 1 December 2015 / Accepted: 4 December 2015 / Published: 14 December 2015
Show/Hide Abstract | PDF Full-text (2322 KB) | HTML Full-text | XML Full-text

by  and
Int. J. Mol. Sci. 2015, 16(12), 29103-29119; doi:10.3390/ijms161226150
Received: 3 November 2015 / Revised: 26 November 2015 / Accepted: 27 November 2015 / Published: 7 December 2015
Show/Hide Abstract | PDF Full-text (871 KB) | HTML Full-text | XML Full-text
abstract graphic

by , , ,  and
Int. J. Mol. Sci. 2015, 16(12), 28943-28978; doi:10.3390/ijms161226138
Received: 5 October 2015 / Revised: 17 November 2015 / Accepted: 26 November 2015 / Published: 4 December 2015
Show/Hide Abstract | PDF Full-text (1755 KB) | HTML Full-text | XML Full-text

by , ,  and
Int. J. Mol. Sci. 2015, 16(12), 28063-28076; doi:10.3390/ijms161226080
Received: 3 September 2015 / Revised: 27 October 2015 / Accepted: 13 November 2015 / Published: 25 November 2015
Show/Hide Abstract | Cited by 1 | PDF Full-text (377 KB) | HTML Full-text | XML Full-text

by , , , ,  and
Int. J. Mol. Sci. 2015, 16(11), 27058-27071; doi:10.3390/ijms161126001
Received: 29 September 2015 / Revised: 29 October 2015 / Accepted: 2 November 2015 / Published: 12 November 2015
Show/Hide Abstract | PDF Full-text (1221 KB) | HTML Full-text | XML Full-text
abstract graphic

by , , ,  and
Int. J. Mol. Sci. 2015, 16(11), 26463-26472; doi:10.3390/ijms161125962
Received: 7 September 2015 / Revised: 22 October 2015 / Accepted: 26 October 2015 / Published: 4 November 2015
Show/Hide Abstract | PDF Full-text (496 KB) | HTML Full-text | XML Full-text

by , , , , , ,  and
Int. J. Mol. Sci. 2015, 16(10), 24243-24275; doi:10.3390/ijms161024243
Received: 8 September 2015 / Revised: 28 September 2015 / Accepted: 30 September 2015 / Published: 14 October 2015
Show/Hide Abstract | Cited by 1 | PDF Full-text (2752 KB) | HTML Full-text | XML Full-text
abstract graphic

by , , , , , ,  and
Int. J. Mol. Sci. 2015, 16(10), 23651-23667; doi:10.3390/ijms161023651
Received: 25 August 2015 / Revised: 21 September 2015 / Accepted: 28 September 2015 / Published: 5 October 2015
Show/Hide Abstract | Cited by 1 | PDF Full-text (1506 KB) | HTML Full-text | XML Full-text
abstract graphic

by ,  and
Int. J. Mol. Sci. 2015, 16(10), 23545-23555; doi:10.3390/ijms161023545
Received: 10 September 2015 / Revised: 23 September 2015 / Accepted: 25 September 2015 / Published: 30 September 2015
Show/Hide Abstract | PDF Full-text (1019 KB) | HTML Full-text | XML Full-text
abstract graphic

by , , , , , , ,  and
Int. J. Mol. Sci. 2015, 16(10), 23382-23389; doi:10.3390/ijms161023382
Received: 22 August 2015 / Revised: 11 September 2015 / Accepted: 23 September 2015 / Published: 29 September 2015
Show/Hide Abstract | Cited by 1 | PDF Full-text (1219 KB) | HTML Full-text | XML Full-text

by , , , , , , ,  and
Int. J. Mol. Sci. 2015, 16(8), 19886-19919; doi:10.3390/ijms160819886
Received: 16 July 2015 / Revised: 16 August 2015 / Accepted: 17 August 2015 / Published: 21 August 2015
Show/Hide Abstract | Cited by 2 | PDF Full-text (1310 KB) | HTML Full-text | XML Full-text
abstract graphic

by ,  and
Int. J. Mol. Sci. 2015, 16(8), 18732-18740; doi:10.3390/ijms160818732
Received: 4 July 2015 / Revised: 4 July 2015 / Accepted: 4 August 2015 / Published: 11 August 2015
Show/Hide Abstract | Cited by 1 | PDF Full-text (979 KB) | HTML Full-text | XML Full-text
abstract graphic

by , , , , , , , ,  and
Int. J. Mol. Sci. 2015, 16(8), 18077-18095; doi:10.3390/ijms160818077
Received: 12 July 2015 / Revised: 28 July 2015 / Accepted: 30 July 2015 / Published: 5 August 2015
Show/Hide Abstract | Cited by 1 | PDF Full-text (1350 KB) | HTML Full-text | XML Full-text | Supplementary Files
abstract graphic

by ,  and
Int. J. Mol. Sci. 2015, 16(7), 16593-16621; doi:10.3390/ijms160716593
Received: 29 May 2015 / Revised: 10 July 2015 / Accepted: 15 July 2015 / Published: 22 July 2015
Show/Hide Abstract | PDF Full-text (870 KB) | HTML Full-text | XML Full-text
abstract graphic

by ,  and
Int. J. Mol. Sci. 2015, 16(6), 12773-12790; doi:10.3390/ijms160612773
Received: 17 May 2015 / Revised: 28 May 2015 / Accepted: 29 May 2015 / Published: 5 June 2015
Show/Hide Abstract | PDF Full-text (898 KB) | HTML Full-text | XML Full-text

by , , ,  and
Int. J. Mol. Sci. 2015, 16(5), 10491-10506; doi:10.3390/ijms160510491
Received: 16 March 2015 / Revised: 22 April 2015 / Accepted: 4 May 2015 / Published: 7 May 2015
Show/Hide Abstract | Cited by 3 | PDF Full-text (4265 KB) | HTML Full-text | XML Full-text

by , , , , , , , , , , ,  and
Int. J. Mol. Sci. 2015, 16(5), 9635-9653; doi:10.3390/ijms16059635
Received: 8 January 2015 / Revised: 24 March 2015 / Accepted: 13 April 2015 / Published: 29 April 2015
Show/Hide Abstract | PDF Full-text (2876 KB) | HTML Full-text | XML Full-text | Supplementary Files

by , , , , , , ,  and
Int. J. Mol. Sci. 2015, 16(4), 8555-8568; doi:10.3390/ijms16048555
Received: 26 February 2015 / Revised: 24 March 2015 / Accepted: 26 March 2015 / Published: 16 April 2015
Show/Hide Abstract | PDF Full-text (8861 KB) | HTML Full-text | XML Full-text | Supplementary Files

by , , , , ,  and
Int. J. Mol. Sci. 2015, 16(4), 6855-6867; doi:10.3390/ijms16046855
Received: 6 October 2014 / Revised: 10 November 2014 / Accepted: 13 November 2014 / Published: 26 March 2015
Show/Hide Abstract | Cited by 1 | PDF Full-text (1027 KB) | HTML Full-text | XML Full-text

by ,  and
Int. J. Mol. Sci. 2015, 16(3), 5467-5496; doi:10.3390/ijms16035467
Received: 12 December 2014 / Revised: 22 February 2015 / Accepted: 3 March 2015 / Published: 10 March 2015
Show/Hide Abstract | Cited by 4 | PDF Full-text (1688 KB) | HTML Full-text | XML Full-text

by ,  and
Int. J. Mol. Sci. 2015, 16(3), 4947-4972; doi:10.3390/ijms16034947
Received: 23 December 2014 / Revised: 17 February 2015 / Accepted: 17 February 2015 / Published: 4 March 2015
Show/Hide Abstract | PDF Full-text (2020 KB) | HTML Full-text | XML Full-text

by  and
Int. J. Mol. Sci. 2015, 16(2), 3251-3266; doi:10.3390/ijms16023251
Received: 17 November 2014 / Accepted: 22 January 2015 / Published: 3 February 2015
Show/Hide Abstract | Cited by 8 | PDF Full-text (2251 KB) | HTML Full-text | XML Full-text
abstract graphic

by  and
Int. J. Mol. Sci. 2015, 16(1), 1395-1405; doi:10.3390/ijms16011395
Received: 16 December 2014 / Accepted: 30 December 2014 / Published: 8 January 2015
Show/Hide Abstract | Cited by 5 | PDF Full-text (1385 KB) | HTML Full-text | XML Full-text

by , , ,  and
Int. J. Mol. Sci. 2015, 16(1), 1448-1465; doi:10.3390/ijms16011448
Received: 1 December 2014 / Accepted: 30 December 2014 / Published: 8 January 2015
Show/Hide Abstract | PDF Full-text (4241 KB) | HTML Full-text | XML Full-text | Supplementary Files
abstract graphic

by ,  and
Int. J. Mol. Sci. 2015, 16(1), 1466-1481; doi:10.3390/ijms16011466
Received: 31 October 2014 / Accepted: 5 January 2015 / Published: 8 January 2015
Show/Hide Abstract | PDF Full-text (2121 KB) | HTML Full-text | XML Full-text

by , , , , , , , , , ,  and
Int. J. Mol. Sci. 2015, 16(1), 1192-1208; doi:10.3390/ijms16011192
Received: 22 November 2014 / Accepted: 26 December 2014 / Published: 6 January 2015
Show/Hide Abstract | Cited by 2 | PDF Full-text (863 KB) | HTML Full-text | XML Full-text | Supplementary Files

2014
by , ,  and
Int. J. Mol. Sci. 2014, 15(11), 21554-21586; doi:10.3390/ijms151121554
Received: 19 September 2014 / Revised: 7 November 2014 / Accepted: 8 November 2014 / Published: 24 November 2014
Show/Hide Abstract | Cited by 5 | PDF Full-text (1422 KB) | HTML Full-text | XML Full-text

by , , ,  and
Int. J. Mol. Sci. 2014, 15(11), 20434-20448; doi:10.3390/ijms151120434
Received: 17 September 2014 / Revised: 30 October 2014 / Accepted: 30 October 2014 / Published: 7 November 2014
Show/Hide Abstract | Cited by 4 | PDF Full-text (1408 KB) | HTML Full-text | XML Full-text

by ,  and
Int. J. Mol. Sci. 2014, 15(11), 20266-20289; doi:10.3390/ijms151120266
Received: 11 August 2014 / Revised: 22 October 2014 / Accepted: 27 October 2014 / Published: 6 November 2014
Show/Hide Abstract | PDF Full-text (428 KB) | HTML Full-text | XML Full-text
abstract graphic

by , , , , , , ,  and
Int. J. Mol. Sci. 2014, 15(11), 20134-20157; doi:10.3390/ijms151120134
Received: 29 May 2014 / Revised: 27 August 2014 / Accepted: 27 October 2014 / Published: 5 November 2014
Show/Hide Abstract | Cited by 4 | PDF Full-text (816 KB) | HTML Full-text | XML Full-text | Supplementary Files

by , ,  and
Int. J. Mol. Sci. 2014, 15(9), 15891-15911; doi:10.3390/ijms150915891
Received: 11 July 2014 / Revised: 27 August 2014 / Accepted: 27 August 2014 / Published: 9 September 2014
Show/Hide Abstract | Cited by 2 | PDF Full-text (1162 KB) | HTML Full-text | XML Full-text
abstract graphic

by  and
Int. J. Mol. Sci. 2014, 15(9), 15700-15733; doi:10.3390/ijms150915700
Received: 20 June 2014 / Revised: 5 August 2014 / Accepted: 13 August 2014 / Published: 4 September 2014
Show/Hide Abstract | Cited by 2 | PDF Full-text (2177 KB) | HTML Full-text | XML Full-text

by , ,  and
Int. J. Mol. Sci. 2014, 15(8), 14475-14491; doi:10.3390/ijms150814475
Received: 2 July 2014 / Revised: 7 August 2014 / Accepted: 12 August 2014 / Published: 20 August 2014
Show/Hide Abstract | Cited by 7 | PDF Full-text (657 KB) | HTML Full-text | XML Full-text
abstract graphic

by , , ,  and
Int. J. Mol. Sci. 2014, 15(8), 13993-14013; doi:10.3390/ijms150813993
Received: 30 June 2014 / Revised: 23 July 2014 / Accepted: 5 August 2014 / Published: 12 August 2014
Show/Hide Abstract | Cited by 2 | PDF Full-text (1096 KB) | HTML Full-text | XML Full-text

by  and
Int. J. Mol. Sci. 2014, 15(8), 13494-13513; doi:10.3390/ijms150813494
Received: 14 June 2014 / Revised: 14 July 2014 / Accepted: 28 July 2014 / Published: 4 August 2014
Show/Hide Abstract | Cited by 2 | PDF Full-text (743 KB) | HTML Full-text | XML Full-text

Planned Papers

The below list represents only planned manuscripts. Some of these manuscripts have not been received by the Editorial Office yet. Papers submitted to MDPI journals are subject to peer-review.

Title: MiR-16-5p is the most stable-expressed housekeeping microRNA in breast cancer tissues from primary and metastatic sites
Authors: Gabriel Rinnerthaler 1,†, Hubert Hackl 2, †, Simon Peter Gampenrieder 1, Frank Hamacher 1, Clemens Hufnagl 1, Franz Zehentmayr 3, Gerd Fastner 3, Felix Sedlmayer 3, Cornelia Hauser-Kronberger 4, Brigitte Mlineritsch 1, Richard Greil 1,
Affiliations: 1 IIIrd Medical Department, Salzburg Cancer Research Institute with Laboratory of Immunological and Molecular Cancer Research and Center for Clinical Cancer and Immunology Trials, Paracelsus Medical University Salzburg; E Mails: g.rinnerthaler@salk.at (G.R.); s.gampenrieder@salk.at (SP.G.); f.hamacher@salk.at (F.H.); cl.hufnagl@salk.at (C.H.); b.mlineritsch@salk.at (B.M.); r.greil@salk.at (R.G.)
2 Division of Bioinformatics, Biocenter, Medical University of Innsbruck, Innsbruck, Austria; E mail: hubert.hackl@i-med.ac.at (H.H.)
3 Department of Radiotherapy, Paracelsus Medical University Salzburg, Austria; E Mails: f.zehentmayr@salk.at (F.Z.); g.fastner@salk.at (G.F.); f.sedlmayer@salk.at (F.S.)
4 Department of Pathology, Paracelsus Medical University Salzburg, Salzburg, Austria; E mail: c.kronberger@salk.at (C.HR.)
These authors contributed equally to this work.
* Author to whom correspondence should be addressed; E-Mail: r.greil@salk.at Tel.: +43-662-4482-2879; Fax: +43-662-4482-2898.
Abstract: Background: For quantitative microRNA analyses in formalin-fixed paraffin-embedded (FFPE) tissue, expression levels have to be normalized to endogenous controls. To investigate the most stable-expressed microRNAs in breast cancer and its surrounding tissue, we used tumor samples from the primary and from metastatic sites.
Patients and methods: MiRNA profiling using TaqMan® Array MicroRNA Cards, enabling quantification of 754 unique human miRNAs, was performed in FFPE specimen from 58 patients with metastatic breast cancer. Forty-two (72%) samples came from primary tumor and 16 (28%) from metastasis. In a cross-platform analysis of a validation cohort of 32 FFPE samples from patients with early breast cancer genome-wide microRNA expression analysis using SurePrintG3 miRNA(8x60K)® microarrays from Agilent® was performed.
Results: Eleven microRNAs could be detected in all analyzed samples. Four of these microRNAs (miR-16-5p, miR-29a-3p miR-126-3p, miR-222-3p) showed also a high correlation with the median of all measured microRNAs (Spearman rank correlation rho ≥ 0.8) and with a coefficient of variation CV from 7 to 11%. In the cross-platform validation 29 human microRNAs were strongly expressed (mean log2-intensity > 10) and 21 of these microRNAs including miR-16-5p were also stably expressed (CV < 5%).
Conclusion: In breast cancer tissues from primary tumor and metastatic sites miR-16-5p is stably expressed and might be considered as most relevant housekeeping microRNA. In a cross-platform analysis of a validation cohort miR-16-5p was confirmed to be a valid endogenous control.

Title: Long non-coding RNAs in Endometrial Carcinoma
Authors: Maria A Smolle 1, Marc D Bullock 2, Hui Ling 3, Martin Pichler 4, Johannes Haybaeck 1
Affiliations: 1 Institute of Pathology, Medical University of Graz, Auenbruggerplatz 25, A-8036 Graz, Austria; E-Mails: maria.smolle@stud.medunigraz.at (MA.S.); Johannes.haybaeck@medunigraz.at (J.H.)
2 Cancer Sciences, Faculty of Medicine, University of Southampton Southampton, UK E-Mail: bullockmd@yahoo.co.uk (MD. B.)
3 Department of Experimental Therapeutics, The University of Texas MD Anderson Cancer Centerh, Houston, USA E-Mail: hling@mdanderson.org (H.L)
4 Division of Clinical Oncology, Department of Medicine, Medical University of Graz, Auenbruggerplatz 15, A-8036 Graz, Austria; E-Mail: martin.pichler@medunigraz.at (M.P.)
Corresponding Author: Johannes Haybaeck; Johannes.haybaeck@medunigraz.at; Tel: +43-316-385-80594; Fax: +43-316-384-329
Abstract: Endometrial carcinoma (EC), the second most common form of gynaecological malignancy, can be divided into two distinct sub-types: Type I tumours arise from hyperplastic endometrium and typically effect younger women, whereas type II tumours arise in postmenopausal women from atrophic endometrium.
Long non-coding RNAs (lncRNAs) are a novel class of non-protein coding molecules which have recently been implicated in the pathogenesis of all types of cancer including gynaecological tumours. Although they play critical physiological roles in cellular metabolism, their expression and function are deregulated in EC compared with paired normal tissue, indicating that they may also participate tumour initatiation and progression. For instance, the lncRNA MALAT-1 is down-regulated in EC samples compared to normal or hyperplastic endometrium, whereas the lncRNA OVAL is down-regulated in type II disease but up-regulated in type I disease. Other notatble lncRNAs such as HOTAIR, H19 and SRA become up-regulated with increasing EC tumour grade and other poor prognosis features.
In the current review, we will examine the growing body of evidence linking deregulated lncRNAs with specific biological functions of tumor cells in EC, we will highlight associations between lncRNAs and molecular pathways implicated in EC tumorogesis and we will identify critical knowledge gaps that remain to be addressed.
Keywords: long non-coding RNAs, endometrial carcinoma, cancer

Title: MicroRNAs and their clinical relevance in Colorectal Cancer
Authors: Joe Thomas, Masahisa Ohtsuka, Martin Pichler, Hui Ling
Affiliation: Department of Experimental Therapeutics, The University of Texas MD Anderson Cancer Centerh, Houston, USA E-Mail: hling@mdanderson.org (all authors)
Abstract: Colorectal cancer is one of the most common cancer diagnoses and causes of mortality worldwide. MicroRNAs are a class of small, non-coding regulatory RNAs that have shown intensive associations with colorectal cancer. Through the repression of target messenger RNAs, microRNAs modulate many cellular pathways, such as those involved in cell proliferation, apoptosis, and differentiation. The utilization of microRNAs has shown significant promise in the diagnosis and prognosis of colorectal cancer, owing to their unique expression profiles association with cancer types and malignancies. Moreover, microRNA therapeutics with mimics or antagonists show great promise in preclinical studies, which encourages further development of microRNA therapeutics into clinical usages for colorectal cancer patients. The unique ability of microRNAs to affect multiple downstream pathways represents a novel approach for cancer therapy. Although still early in its development, we believe that microRNAs can be used in the near future as biomarkers and therapeutic targets for colorectal cancer.
Keywords: colorectal cancer; miRNA; pathophysiology; diagnosis; prognosis; treatment

Title: Micro-RNAs in Acute Myeloid Leukemia: Implications in Pathogenesis and Potential Clinical Applications
Authors: Rmin Zebisch 1, Stefan Hatzl 1, Albert Woelfler 1, Marcel Scheideler 2,3,4,5 and Heinz Sill 1
Affiliations: 1 Division of Hematology, Medical University of Graz, Graz, Austria; 2 Institute for Diabetes and Cancer, Helmholtz Center Munich, Munich, Germany; 3 University Hospital, Heidelberg University, Heidelberg, Germany; 4 German Center for Diabetes Research (DZD), Neuherberg, Germany; 5 Technical University of Munich, Munich, Germany
Abstract: Acute myeloid leukemia (AML) is caused by malignant transformation of hematopoietic stem or progenitor cells and displays the most frequent acute leukemia in adults. Although some patients can be cured with high dose chemotherapy and allogeneic hematopoietic stem cell transplantation, the majority still succumbs to chemoresistant disease and/or relapse. Micro-RNAs are small non-coding RNAs and act as key players in the regulation of both physiologic and pathologic gene expression profiles. Aberrant expression of various micro-RNAs proved to be of seminal importance in the pathogenesis of AML, both at primary disease manifestation and at development of chemoresistance and/or relapse. Micro-RNAs further proved to be valuable diagnostic and prognostic AML biomarkers with the potential to refine current classification schemes. In this review, we discuss these issues and provide an outlook on potential therapeutic targets emerging thereof.

Last update: 21 January 2016

Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert