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Int. J. Mol. Sci. 2017, 18(12), 2505; https://doi.org/10.3390/ijms18122505

Long Non-Coding RNAs in Hepatitis B Virus-Related Hepatocellular Carcinoma: Regulation, Functions, and Underlying Mechanisms

1
Institute of Life Sciences, Jiangsu University, Zhenjiang 212013, China
2
School of Pharmacy, Jiangsu University, Zhenjiang 212013, China
3
Department of Pharmacy, College of Life Sciences, China Jiliang University, Hangzhou 310018, China
*
Authors to whom correspondence should be addressed.
Received: 27 September 2017 / Revised: 13 November 2017 / Accepted: 20 November 2017 / Published: 23 November 2017
(This article belongs to the Collection Regulation by Non-Coding RNAs)
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Abstract

Hepatocellular carcinoma (HCC) is the fifth most common cancer and the third leading cause of cancer death in the world. Hepatitis B virus (HBV) and its X gene-encoded protein (HBx) play important roles in the progression of HCC. Although long non-coding RNAs (lncRNAs) cannot encode proteins, growing evidence indicates that they play essential roles in HCC progression, and contribute to cell proliferation, invasion and metastasis, autophagy, and apoptosis by targeting a large number of pivotal protein-coding genes, miRNAs, and signaling pathways. In this review, we briefly outline recent findings of differentially expressed lncRNAs in HBV-related HCC, with particular focus on several key lncRNAs, and discuss their regulation by HBV/HBx, their functions, and their underlying molecular mechanisms in the progression of HCC. View Full-Text
Keywords: lncRNAs; HBV; HBx; HCC; proliferation; epithelial-mesenchymal transition; invasion and metastasis; apoptosis; autophagy lncRNAs; HBV; HBx; HCC; proliferation; epithelial-mesenchymal transition; invasion and metastasis; apoptosis; autophagy
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).
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Qiu, L.; Wang, T.; Xu, X.; Wu, Y.; Tang, Q.; Chen, K. Long Non-Coding RNAs in Hepatitis B Virus-Related Hepatocellular Carcinoma: Regulation, Functions, and Underlying Mechanisms. Int. J. Mol. Sci. 2017, 18, 2505.

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