Special Issue "Non-Coding RNAs"

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A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Biochemistry, Molecular Biology and Biophysics".

Deadline for manuscript submissions: closed (31 October 2011)

Special Issue Editor

Guest Editor
Prof. Dr. Constantinos Stathopoulos
Department of Biochemistry, School of Medicine, University of Patras, 1 Asklipiou st., 26504 Patras, Greece
Website: http://biochemistry.med.upatras.gr/lang_en/laboratory/viewCV/2
E-Mail: cstath@med.upatras.gr
Phone: +30 2610 997932 (office); +30 2610 997936 (lab)
Fax: +30 2610 969167

Special Issue Information

Dear Colleagues,

During recent years, a remarkable expansion of the “RNA world” members has been observed with the discovery and characterization of many elusive, so far, RNA molecules of various sizes and regulatory roles, in both eukaryotes and bacteria. In the dawn of this new RNA era, the term “non-coding RNAs” represents not only molecules such as tRNAs, rRNAs and snoRNAs, that cannot be translated into proteins. Instead, it additionally includes a variety of prominent RNA molecules that play distinct and critical roles within the cell. In eukaryotes, these novel members are represented by numerous microRNAs, siRNAs, piRNAs and long non-coding RNAs, that exhibit trans-acting antisense modulating properties. Today, we know that they modulate gene expression by interfering in post-transcriptional level. Moreover, RNA interference-based methodologies have provided the means of studying gene expression at a glance, both in vitro and in vivo, and they have emerged as very delicate and promising therapeutic strategies. In bacteria, the new members are represented by many regulatory RNAs of various sizes, which are also responsible for essential cellular responses. These key elements, can either be embedded in the 5’ end of mRNAs (i.e. riboswitches), they can be small RNAs that act in trans by targeting proteins or RNAs, they can be long antisense RNA modulators (CRISPR RNAs) or they may even have intrinsic activity (like RNase P ribozyme). Whatever their origin, size, structure or specific role, it is more than evident that non-coding RNAs represent a dynamic and expanding family of essential molecules, some of them with deep evolutionary history. Moreover, they are established as valuable novel tools with biotechnological applications or/and targets for combating disease or pathogens. Their discovery and study has great impact not only in the way we approach specific cellular processes today, but also in the way we understand the evolution of life itself.

Prof. Dr. Constantinos Stathopoulos
Guest Editor

Keywords

  • tRNA
  • rRNA
  • snoRNA
  • ribozyme
  • microRNA
  • siRNA
  • piRNA
  • riboswitch
  • sRNA
  • CRISPR RNA

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Published Papers (12 papers)

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Displaying article 1-12
p. 4934-4968
by  and
Int. J. Mol. Sci. 2013, 14(3), 4934-4968; doi:10.3390/ijms14034934
Received: 10 December 2012; in revised form: 9 February 2013 / Accepted: 18 February 2013 / Published: 1 March 2013
Show/Hide Abstract | Cited by 7 | PDF Full-text (372 KB) | HTML Full-text | XML Full-text
(This article belongs to the Special Issue Non-Coding RNAs)
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p. 1278-1292
by , ,  and
Int. J. Mol. Sci. 2013, 14(1), 1278-1292; doi:10.3390/ijms14011278
Received: 6 November 2012; in revised form: 28 December 2012 / Accepted: 4 January 2013 / Published: 10 January 2013
Show/Hide Abstract | Cited by 7 | PDF Full-text (448 KB) | HTML Full-text | XML Full-text
(This article belongs to the Special Issue Non-Coding RNAs)
p. 2063-2077
by , , , , ,  and
Int. J. Mol. Sci. 2012, 13(2), 2063-2077; doi:10.3390/ijms13022063
Received: 4 November 2011; in revised form: 3 February 2012 / Accepted: 7 February 2012 / Published: 15 February 2012
Show/Hide Abstract | Cited by 6 | PDF Full-text (364 KB) | HTML Full-text | XML Full-text | Supplementary Files
(This article belongs to the Special Issue Non-Coding RNAs)
p. 1347-1379
by , , , , ,  and
Int. J. Mol. Sci. 2012, 13(2), 1347-1379; doi:10.3390/ijms13021347
Received: 28 November 2011; in revised form: 9 January 2012 / Accepted: 9 January 2012 / Published: 27 January 2012
Show/Hide Abstract | Cited by 6 | PDF Full-text (1073 KB) | HTML Full-text | XML Full-text
(This article belongs to the Special Issue Non-Coding RNAs)
p. 1173-1185
by , , ,  and
Int. J. Mol. Sci. 2012, 13(1), 1173-1185; doi:10.3390/ijms13011173
Received: 2 December 2011; in revised form: 5 January 2012 / Accepted: 13 January 2012 / Published: 20 January 2012
Show/Hide Abstract | Cited by 5 | PDF Full-text (354 KB) | HTML Full-text | XML Full-text | Supplementary Files
(This article belongs to the Special Issue Non-Coding RNAs)
p. 558-578
by  and
Int. J. Mol. Sci. 2012, 13(1), 558-578; doi:10.3390/ijms13010558
Received: 3 December 2011; in revised form: 20 December 2011 / Accepted: 21 December 2011 / Published: 5 January 2012
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p. 477-490
by
Int. J. Mol. Sci. 2012, 13(1), 477-490; doi:10.3390/ijms13010477
Received: 23 November 2011; in revised form: 22 December 2011 / Accepted: 23 December 2011 / Published: 4 January 2012
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(This article belongs to the Special Issue Non-Coding RNAs)
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p. 9265-9276
by ,  and
Int. J. Mol. Sci. 2011, 12(12), 9265-9276; doi:10.3390/ijms12129265
Received: 24 October 2011; in revised form: 22 November 2011 / Accepted: 29 November 2011 / Published: 12 December 2011
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p. 9155-9171
by  and
Int. J. Mol. Sci. 2011, 12(12), 9155-9171; doi:10.3390/ijms12129155
Received: 24 October 2011; in revised form: 24 November 2011 / Accepted: 28 November 2011 / Published: 8 December 2011
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(This article belongs to the Special Issue Non-Coding RNAs)
p. 8695-8712
by , , , , , , , , ,  and
Int. J. Mol. Sci. 2011, 12(12), 8695-8712; doi:10.3390/ijms12128695
Received: 19 September 2011; in revised form: 31 October 2011 / Accepted: 22 November 2011 / Published: 1 December 2011
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(This article belongs to the Special Issue Non-Coding RNAs)
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p. 8661-8694
by ,  and
Int. J. Mol. Sci. 2011, 12(12), 8661-8694; doi:10.3390/ijms12128661
Received: 9 August 2011; in revised form: 7 November 2011 / Accepted: 10 November 2011 / Published: 30 November 2011
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(This article belongs to the Special Issue Non-Coding RNAs)
p. 5070-5079
by ,  and
Int. J. Mol. Sci. 2011, 12(8), 5070-5079; doi:10.3390/ijms12085070
Received: 28 June 2011; in revised form: 15 July 2011 / Accepted: 8 August 2011 / Published: 10 August 2011
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Last update: 7 August 2014

Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert