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Int. J. Mol. Sci. 2017, 18(4), 890; doi:10.3390/ijms18040890

Regulatory miRNAs in Colorectal Carcinogenesis and Metastasis

1
Department of Pathology and Institute of Precision Medicine, Jining Medical University, 16 Hehua Road, Jining 272067, China
2
Department of Pathology, University of Illinois at Chicago, Chicago, IL 60612, USA
*
Author to whom correspondence should be addressed.
Academic Editor: Martin Pichler
Received: 30 March 2017 / Revised: 15 April 2017 / Accepted: 20 April 2017 / Published: 22 April 2017
(This article belongs to the Collection Regulation by Non-Coding RNAs)
View Full-Text   |   Download PDF [520 KB, uploaded 22 April 2017]   |  

Abstract

Colorectal cancer is one of the most common malignancies and is the second-leading cause of cancer-related death world-wide, which is linked to genetic mutations, epigenetic alterations, and oncogenic signaling activation. MicroRNAs, one of the categories of epigenetics, have been demonstrated significant roles in carcinogenesis and progression through regulating of oncogenic signaling pathways, stem cells, epithelial-mesenchymal transition, and metastasis. This review summarizes the roles of microRNAs in the regulating of Wnt, Ras, TGF-β, and inflammatory signaling pathways, stemness, and epithelial-mesenchymal transition, for carcinogenesis and metastasis in colorectal cancer. Improving our understanding of the mechanisms of regulatory interactions of microRNAs with signaling pathways in colorectal cancer formation and progression will aid in determining the genes responsible for colorectal cancer initiation, progression, metastasis, and recurrence and, finally, in developing personalized approaches for cancer prevention and therapy. View Full-Text
Keywords: colorectal cancer; miRNA; epithelial-mesenchymal transition (EMT); cancer stem cells; metastasis colorectal cancer; miRNA; epithelial-mesenchymal transition (EMT); cancer stem cells; metastasis
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Guo, Y.; Bao, Y.; Yang, W. Regulatory miRNAs in Colorectal Carcinogenesis and Metastasis. Int. J. Mol. Sci. 2017, 18, 890.

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