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Int. J. Mol. Sci. 2014, 15(8), 14475-14491; doi:10.3390/ijms150814475
Review

MicroRNAs, Genomic Instability and Cancer

1
, 1
, 2
 and 1,*
Received: 2 July 2014; in revised form: 7 August 2014 / Accepted: 12 August 2014 / Published: 20 August 2014
(This article belongs to the collection Regulation by Non-Coding RNAs)
View Full-Text   |   Download PDF [657 KB, uploaded 20 August 2014]
Abstract: MicroRNAs (miRNAs) are small non-coding RNA transcripts approximately 20 nucleotides in length that regulate expression of protein-coding genes via complementary binding mechanisms. The last decade has seen an exponential increase of publications on miRNAs, ranging from every aspect of basic cancer biology to diagnostic and therapeutic explorations. In this review, we summarize findings of miRNA involvement in genomic instability, an interesting but largely neglected topic to date. We discuss the potential mechanisms by which miRNAs induce genomic instability, considered to be one of the most important driving forces of cancer initiation and progression, though its precise mechanisms remain elusive. We classify genomic instability mechanisms into defects in cell cycle regulation, DNA damage response, and mitotic separation, and review the findings demonstrating the participation of specific miRNAs in such mechanisms.
Keywords: microRNAs; genomic instability; cancer microRNAs; genomic instability; cancer
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Vincent, K.; Pichler, M.; Lee, G.-W.; Ling, H. MicroRNAs, Genomic Instability and Cancer. Int. J. Mol. Sci. 2014, 15, 14475-14491.

AMA Style

Vincent K, Pichler M, Lee G-W, Ling H. MicroRNAs, Genomic Instability and Cancer. International Journal of Molecular Sciences. 2014; 15(8):14475-14491.

Chicago/Turabian Style

Vincent, Kimberly; Pichler, Martin; Lee, Gyeong-Won; Ling, Hui. 2014. "MicroRNAs, Genomic Instability and Cancer." Int. J. Mol. Sci. 15, no. 8: 14475-14491.


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