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Int. J. Mol. Sci. 2017, 18(4), 715; doi:10.3390/ijms18040715

Function and Clinical Implications of Long Non-Coding RNAs in Melanoma

1
Institute of Experimental and Clinical Pharmacology, Medical University of Graz, Graz 8010, Austria
2
Department of Dermatology, Medical University of Graz, Graz 8036, Austria
3
Institute for Pathology, Medical University of Graz, Graz 8036, Austria
4
Division of Hematology, Department of Internal Medicine, Medical University of Graz, Graz 8036, Austria
5
Faculty of Medicine, Martin-Luther-University Halle-Wittenberg, Halle (Saale) 06120, Germany
6
Division of Clinical Oncology, Department of Medicine, Medical University of Graz, Graz 8036, Austria
*
Authors to whom correspondence should be addressed.
Academic Editor: Andrzej Slominski
Received: 19 February 2017 / Revised: 16 March 2017 / Accepted: 17 March 2017 / Published: 28 March 2017
(This article belongs to the Collection Regulation by Non-Coding RNAs)
View Full-Text   |   Download PDF [704 KB, uploaded 28 March 2017]   |  

Abstract

Metastatic melanoma is the most deadly type of skin cancer. Despite the success of immunotherapy and targeted agents, the majority of patients experience disease recurrence upon treatment and die due to their disease. Long non-coding RNAs (lncRNAs) are a new subclass of non-protein coding RNAs involved in (epigenetic) regulation of cell growth, invasion, and other important cellular functions. Consequently, recent research activities focused on the discovery of these lncRNAs in a broad spectrum of human diseases, especially cancer. Additional efforts have been undertaken to dissect the underlying molecular mechanisms employed by lncRNAs. In this review, we will summarize the growing evidence of deregulated lncRNA expression in melanoma, which is linked to tumor growth and progression. Moreover, we will highlight specific molecular pathways and modes of action for some well-studied lncRNAs and discuss their potential clinical implications. View Full-Text
Keywords: lncRNA; skin cancer lncRNA; skin cancer
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Richtig, G.; Ehall, B.; Richtig, E.; Aigelsreiter, A.; Gutschner, T.; Pichler, M. Function and Clinical Implications of Long Non-Coding RNAs in Melanoma. Int. J. Mol. Sci. 2017, 18, 715.

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