Special Issue "Non-Coding RNAs 2012"

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A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Biochemistry, Molecular Biology and Biophysics".

Deadline for manuscript submissions: closed (31 October 2012)

Special Issue Editor

Guest Editor
Prof. Dr. Constantinos Stathopoulos
Department of Biochemistry, School of Medicine, University of Patras, 1 Asklipiou st., 26504 Patras, Greece
Website: http://biochemistry.med.upatras.gr/lang_en/laboratory/viewCV/2
E-Mail: cstath@med.upatras.gr
Phone: +30 2610 997932 (office); +30 2610 997936 (lab)
Fax: +30 2610 969167

Special Issue Information

Dear Colleagues,

During recent years, a remarkable expansion of the “RNA world” members has been observed with the discovery and characterization of many elusive, so far, RNA molecules of various sizes and regulatory roles, in both eukaryotes and bacteria. In the dawn of this new RNA era, the term “non-coding RNAs” represents not only molecules such as tRNAs, rRNAs and snoRNAs, that cannot be translated into proteins. Instead, it additionally includes a variety of prominent RNA molecules that play distinct and critical roles within the cell. In eukaryotes, these novel members are represented by numerous microRNAs, siRNAs, piRNAs and long non-coding RNAs, that exhibit trans-acting antisense modulating properties. Today, we know that they modulate gene expression by interfering in post-transcriptional level. Moreover, RNA interference-based methodologies have provided the means of studying gene expression at a glance, both in vitro and in vivo, and they have emerged as very delicate and promising therapeutic strategies. In bacteria, the new members are represented by many regulatory RNAs of various sizes, which are also responsible for essential cellular responses. These key elements, can either be embedded in the 5’ end of mRNAs (i.e. riboswitches), they can be small RNAs that act in trans by targeting proteins or RNAs, they can be long antisense RNA modulators (CRISPR RNAs) or they may even have intrinsic activity (like RNase P ribozyme). Whatever their origin, size, structure or specific role, it is more than evident that non-coding RNAs represent a dynamic and expanding family of essential molecules, some of them with deep evolutionary history. Moreover, they are established as valuable novel tools with biotechnological applications or/and targets for combating disease or pathogens. Their discovery and study has great impact not only in the way we approach specific cellular processes today, but also in the way we understand the evolution of life itself.

Prof. Dr. Constantinos Stathopoulos
Guest Editor

Keywords

  • tRNA
  • rRNA
  • snoRNA
  • ribozyme
  • microRNA
  • siRNA
  • piRNA
  • riboswitch
  • sRNA
  • CRISPR RNA

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Published Papers (21 papers)

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Displaying article 1-21
p. 6144-6156
by ,  and
Int. J. Mol. Sci. 2013, 14(3), 6144-6156; doi:10.3390/ijms14036144
Received: 20 November 2012; in revised form: 28 January 2013 / Accepted: 28 February 2013 / Published: 18 March 2013
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(This article belongs to the Special Issue Non-Coding RNAs 2012)
p. 5519-5544
by , ,  and
Int. J. Mol. Sci. 2013, 14(3), 5519-5544; doi:10.3390/ijms14035519
Received: 21 January 2013; in revised form: 26 February 2013 / Accepted: 4 March 2013 / Published: 8 March 2013
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(This article belongs to the Special Issue Non-Coding RNAs 2012)
p. 4560-4579
by  and
Int. J. Mol. Sci. 2013, 14(3), 4560-4579; doi:10.3390/ijms14034560
Received: 18 January 2013; in revised form: 10 February 2013 / Accepted: 16 February 2013 / Published: 26 February 2013
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(This article belongs to the Special Issue Non-Coding RNAs 2012)
p. 4298-4316
by , , , , , , ,  and
Int. J. Mol. Sci. 2013, 14(2), 4298-4316; doi:10.3390/ijms14024298
Received: 3 December 2012; in revised form: 29 January 2013 / Accepted: 6 February 2013 / Published: 21 February 2013
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(This article belongs to the Special Issue Non-Coding RNAs 2012)
p. 2717-2738
by , , , , , ,  and
Int. J. Mol. Sci. 2013, 14(2), 2717-2738; doi:10.3390/ijms14022717
Received: 10 November 2012; in revised form: 9 January 2013 / Accepted: 15 January 2013 / Published: 28 January 2013
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(This article belongs to the Special Issue Non-Coding RNAs 2012)
p. 2072-2084
by , , , , ,  and
Int. J. Mol. Sci. 2013, 14(1), 2072-2084; doi:10.3390/ijms14012072
Received: 6 November 2012; in revised form: 11 December 2012 / Accepted: 17 January 2013 / Published: 22 January 2013
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(This article belongs to the Special Issue Non-Coding RNAs 2012)
p. 1822-1842
by ,  and
Int. J. Mol. Sci. 2013, 14(1), 1822-1842; doi:10.3390/ijms14011822
Received: 20 November 2012; in revised form: 28 December 2012 / Accepted: 10 January 2013 / Published: 16 January 2013
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(This article belongs to the Special Issue Non-Coding RNAs 2012)
p. 1516-1540
by ,  and
Int. J. Mol. Sci. 2013, 14(1), 1516-1540; doi:10.3390/ijms14011516
Received: 21 November 2012; in revised form: 9 December 2012 / Accepted: 10 December 2012 / Published: 14 January 2013
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(This article belongs to the Special Issue Non-Coding RNAs 2012)
p. 1566-1588
by  and
Int. J. Mol. Sci. 2013, 14(1), 1566-1588; doi:10.3390/ijms14011566
Received: 12 December 2012; in revised form: 31 December 2012 / Accepted: 4 January 2013 / Published: 14 January 2013
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(This article belongs to the Special Issue Non-Coding RNAs 2012)
p. 1105-1118
by , , , , , , ,  and
Int. J. Mol. Sci. 2013, 14(1), 1105-1118; doi:10.3390/ijms14011105
Received: 31 October 2012; in revised form: 11 December 2012 / Accepted: 24 December 2012 / Published: 8 January 2013
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(This article belongs to the Special Issue Non-Coding RNAs 2012)
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p. 611-624
by , , ,  and
Int. J. Mol. Sci. 2013, 14(1), 611-624; doi:10.3390/ijms14010611
Received: 2 November 2012; in revised form: 14 December 2012 / Accepted: 18 December 2012 / Published: 28 December 2012
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(This article belongs to the Special Issue Non-Coding RNAs 2012)
p. 480-495
by  and
Int. J. Mol. Sci. 2013, 14(1), 480-495; doi:10.3390/ijms14010480
Received: 12 November 2012; in revised form: 6 December 2012 / Accepted: 6 December 2012 / Published: 27 December 2012
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(This article belongs to the Special Issue Non-Coding RNAs 2012)
p. 378-393
by , , ,  and
Int. J. Mol. Sci. 2013, 14(1), 378-393; doi:10.3390/ijms14010378
Received: 5 November 2012; in revised form: 11 December 2012 / Accepted: 14 December 2012 / Published: 24 December 2012
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(This article belongs to the Special Issue Non-Coding RNAs 2012)
p. 205-225
by , , , , , , ,  and
Int. J. Mol. Sci. 2013, 14(1), 205-225; doi:10.3390/ijms14010205
Received: 5 November 2012; in revised form: 30 November 2012 / Accepted: 10 December 2012 / Published: 21 December 2012
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(This article belongs to the Special Issue Non-Coding RNAs 2012)
p. 16708-16717
by  and
Int. J. Mol. Sci. 2012, 13(12), 16708-16717; doi:10.3390/ijms131216708
Received: 5 November 2012; in revised form: 3 December 2012 / Accepted: 3 December 2012 / Published: 6 December 2012
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(This article belongs to the Special Issue Non-Coding RNAs 2012)
p. 16554-16579
by , , , ,  and
Int. J. Mol. Sci. 2012, 13(12), 16554-16579; doi:10.3390/ijms131216554
Received: 29 October 2012; in revised form: 21 November 2012 / Accepted: 21 November 2012 / Published: 5 December 2012
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(This article belongs to the Special Issue Non-Coding RNAs 2012)
p. 16223-16240
by ,  and
Int. J. Mol. Sci. 2012, 13(12), 16223-16240; doi:10.3390/ijms131216223
Received: 21 October 2012; in revised form: 21 November 2012 / Accepted: 27 November 2012 / Published: 30 November 2012
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(This article belongs to the Special Issue Non-Coding RNAs 2012)
p. 15826-15847
by , ,  and
Int. J. Mol. Sci. 2012, 13(12), 15826-15847; doi:10.3390/ijms131215826
Received: 1 November 2012; in revised form: 20 November 2012 / Accepted: 21 November 2012 / Published: 27 November 2012
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(This article belongs to the Special Issue Non-Coding RNAs 2012)
p. 15496-15509
by , ,  and
Int. J. Mol. Sci. 2012, 13(12), 15496-15509; doi:10.3390/ijms131215496
Received: 29 October 2012; in revised form: 16 November 2012 / Accepted: 19 November 2012 / Published: 22 November 2012
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(This article belongs to the Special Issue Non-Coding RNAs 2012)
p. 13134-13139
by ,  and
Int. J. Mol. Sci. 2012, 13(10), 13134-13139; doi:10.3390/ijms131013134
Received: 31 July 2012; in revised form: 22 September 2012 / Accepted: 26 September 2012 / Published: 12 October 2012
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(This article belongs to the Special Issue Non-Coding RNAs 2012)
p. 8449-8466
by  and
Int. J. Mol. Sci. 2012, 13(7), 8449-8466; doi:10.3390/ijms13078449
Received: 8 June 2012; in revised form: 29 June 2012 / Accepted: 2 July 2012 / Published: 9 July 2012
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(This article belongs to the Special Issue Non-Coding RNAs 2012)
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Last update: 7 August 2014

Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert