Special Issue "Regulation by non-coding RNAs"

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A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Biochemistry, Molecular Biology and Biophysics".

Deadline for manuscript submissions: closed (15 October 2013)

Special Issue Editors

Guest Editor
Prof. Dr. Nicholas Delihas
Department of Molecular Genetics and Microbiology, School of Medicine, 158 Life Sciences Building, Stony Brook University, Stony Brook, NY 11794, USA
Website: http://www.mgm.stonybrook.edu/delihas/index.shtml
E-Mail: Nicholas.delihas@stonybrook.edu
Phone: +1 631 632 8779
Fax: +1 631 632 9797
Interests: regulation of gene expression by small RNAs; annotation of genes; repetitive sequences in intergenic regions in bacteria

Co-Guest Editor
Prof. Dr. Constantinos Stathopoulos
Department of Biochemistry, School of Medicine, University of Patras, 1 Asklipiou st., 26504 Patras, Greece
Website: http://biochemistry.med.upatras.gr/lang_en/laboratory/viewCV/2
E-Mail: cstath@med.upatras.gr
Phone: +30 2610 997932 (office); +30 2610 997936 (lab)
Fax: +30 2610 969167

Special Issue Information

Dear Colleagues,

Regulatory non-protein-coding RNA genes and their transcripts were first found and characterized in bacteria but encompass all biological kingdoms. The complexity of non-coding RNAs (ncRNAs) in terms of number and types increases with degree of biological development, whereby humans and other primates appear to have the largest number. Many regulatory ncRNAs base-pair to a target RNA or DNA and inhibit target function. Bacterial ncRNA genes largely respond to environmental stress conditions and help protect the organism from adverse conditions. The prokaryotic RNAs are for the most part small (<200 bp) and are commonly referred to as small regulatory RNAs (sRNAs). Eukaryotic RNAs consist of small <200 nt RNAs and large >200 nt (termed lncRNAs). The eukaryotic small RNAs include miRNAs, siRNAs, and piRNAs. miRNAs inhibit mRNA functions and may also be associated with cancer. lncRNAs functions are multifaceted and include epigenetic regulation and animal development. The bacterial and archeal immune system CRISPR, and the eukaryotic piwi-interacting RNAs (piRNA) immune system that inhibits mobile elements in germ line cells both function by via RNA transcript/ target DNA heteroduplex base-pairing are a specific class of RNAs that protect cells from invading transposons/and or viruses. siRNAs function in plant and invertebrate immune systems and protect against viral infections. Additionally, small RNA fragments derived from snoRNAs and tRNAs as well as18 nt RNAs (tiRNAs) derived from eukaryotic transcription start sites may play a role in regulation. Exciting new findings with non-protein coding sequences of the human genome show that a major portion of the genome is transcribed. This provides the possibility that larger numbers of functional RNAs may be found in addition to the several thousand known ones. The precepts of genes and genetic inheritance may have to change to include RNA genes and their transcripts and this would represent a starling change in the principles of molecular genetics.

This special issue of IJMS will be devoted to original papers and reviews of properties and mechanism of action of regulatory non-coding RNAs and will be organized into prokaryotic and eukaryotic RNAs with separate subtopics involving regulatory ncRNAs in plants and animals. There will be a special emphasis on RNAs in humans and their significance to disease formation and will include roles of ncRNAs in neurodegeneration, cancer, diabetes and other diseases.

Prof. Dr. Nicholas Delihas
Prof. Dr. Constantinos Stathopoulos
Guest Editor


Printed Edition Available!

A printed edition of this special issue is available via books.mdpi.com.

Price: 116 CHF/Vol.1 86CHF/Vol.2 (hardcover, excl. shipping), 9 CHF (PDF version), free online access

Keywords

  • Regulatory RNA
  • sRNA
  • ncRNA
  • lncRNA
  • miRNA
  • siRNA
  • piRNA
  • CRISPR RNA
  • regulatory small RNA fragments

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Published Papers (52 papers)

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p. 11713-11729
by , ,  and
Int. J. Mol. Sci. 2014, 15(7), 11713-11729; doi:10.3390/ijms150711713
Received: 13 May 2014; in revised form: 2 June 2014 / Accepted: 4 June 2014 / Published: 2 July 2014
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(This article belongs to the Special Issue Regulation by non-coding RNAs)
p. 839-849
by ,  and
Int. J. Mol. Sci. 2014, 15(1), 839-849; doi:10.3390/ijms15010839
Received: 12 November 2013; in revised form: 19 November 2013 / Accepted: 30 December 2013 / Published: 9 January 2014
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(This article belongs to the Special Issue Regulation by non-coding RNAs)
p. 23160-23187
by , , , , ,  and
Int. J. Mol. Sci. 2013, 14(11), 23160-23187; doi:10.3390/ijms141123160
Received: 9 August 2013; in revised form: 23 October 2013 / Accepted: 2 November 2013 / Published: 21 November 2013
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(This article belongs to the Special Issue Regulation by non-coding RNAs)
p. 22796-22816
by , , , ,  and
Int. J. Mol. Sci. 2013, 14(11), 22796-22816; doi:10.3390/ijms141122796
Received: 8 October 2013; in revised form: 4 November 2013 / Accepted: 5 November 2013 / Published: 19 November 2013
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p. 22642-22654
by , ,  and
Int. J. Mol. Sci. 2013, 14(11), 22642-22654; doi:10.3390/ijms141122642
Received: 15 October 2013; in revised form: 31 October 2013 / Accepted: 31 October 2013 / Published: 18 November 2013
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p. 21960-21964
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Int. J. Mol. Sci. 2013, 14(11), 21960-21964; doi:10.3390/ijms141121960
Received: 22 September 2013; Accepted: 31 October 2013 / Published: 6 November 2013
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p. 20427-20442
by , ,  and
Int. J. Mol. Sci. 2013, 14(10), 20427-20442; doi:10.3390/ijms141020427
Received: 14 June 2013; in revised form: 18 September 2013 / Accepted: 25 September 2013 / Published: 14 October 2013
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p. 19987-20018
by , ,  and
Int. J. Mol. Sci. 2013, 14(10), 19987-20018; doi:10.3390/ijms141019987
Received: 4 July 2013; in revised form: 12 September 2013 / Accepted: 16 September 2013 / Published: 9 October 2013
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p. 19681-19704
by ,  and
Int. J. Mol. Sci. 2013, 14(10), 19681-19704; doi:10.3390/ijms141019681
Received: 5 August 2013; in revised form: 5 September 2013 / Accepted: 9 September 2013 / Published: 30 September 2013
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p. 19587-19604
by , , ,  and
Int. J. Mol. Sci. 2013, 14(10), 19587-19604; doi:10.3390/ijms141019587
Received: 31 May 2013; in revised form: 6 September 2013 / Accepted: 16 September 2013 / Published: 27 September 2013
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p. 18790-18808
by ,  and
Int. J. Mol. Sci. 2013, 14(9), 18790-18808; doi:10.3390/ijms140918790
Received: 20 June 2013; in revised form: 28 August 2013 / Accepted: 3 September 2013 / Published: 12 September 2013
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p. 18239-18255
by ,  and
Int. J. Mol. Sci. 2013, 14(9), 18239-18255; doi:10.3390/ijms140918239
Received: 22 July 2013; in revised form: 8 August 2013 / Accepted: 13 August 2013 / Published: 5 September 2013
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p. 18319-18349
by  and
Int. J. Mol. Sci. 2013, 14(9), 18319-18349; doi:10.3390/ijms140918319
Received: 8 July 2013; in revised form: 23 August 2013 / Accepted: 30 August 2013 / Published: 5 September 2013
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p. 17378-17409
by ,  and
Int. J. Mol. Sci. 2013, 14(9), 17378-17409; doi:10.3390/ijms140917378
Received: 8 July 2013; in revised form: 1 August 2013 / Accepted: 13 August 2013 / Published: 23 August 2013
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p. 17347-17377
by  and
Int. J. Mol. Sci. 2013, 14(9), 17347-17377; doi:10.3390/ijms140917347
Received: 1 July 2013; in revised form: 30 July 2013 / Accepted: 12 August 2013 / Published: 22 August 2013
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p. 16958-16969
by , , , ,  and
Int. J. Mol. Sci. 2013, 14(8), 16958-16969; doi:10.3390/ijms140816958
Received: 3 June 2013; in revised form: 8 July 2013 / Accepted: 2 August 2013 / Published: 19 August 2013
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p. 16999-17016
by ,  and
Int. J. Mol. Sci. 2013, 14(8), 16999-17016; doi:10.3390/ijms140816999
Received: 30 May 2013; in revised form: 6 August 2013 / Accepted: 8 August 2013 / Published: 19 August 2013
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p. 17085-17110
by ,  and
Int. J. Mol. Sci. 2013, 14(8), 17085-17110; doi:10.3390/ijms140817085
Received: 5 July 2013; in revised form: 1 August 2013 / Accepted: 8 August 2013 / Published: 19 August 2013
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p. 16532-16553
by  and
Int. J. Mol. Sci. 2013, 14(8), 16532-16553; doi:10.3390/ijms140816532
Received: 31 May 2013; in revised form: 22 July 2013 / Accepted: 25 July 2013 / Published: 9 August 2013
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p. 16280-16302
by
Int. J. Mol. Sci. 2013, 14(8), 16280-16302; doi:10.3390/ijms140816280
Received: 3 June 2013; in revised form: 29 July 2013 / Accepted: 31 July 2013 / Published: 7 August 2013
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p. 16226-16239
by , , , , ,  and
Int. J. Mol. Sci. 2013, 14(8), 16226-16239; doi:10.3390/ijms140816226
Received: 5 June 2013; in revised form: 18 July 2013 / Accepted: 18 July 2013 / Published: 6 August 2013
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p. 16087-16110
by , , , , , , ,  and
Int. J. Mol. Sci. 2013, 14(8), 16087-16110; doi:10.3390/ijms140816087
Received: 8 June 2013; in revised form: 12 July 2013 / Accepted: 26 July 2013 / Published: 5 August 2013
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p. 16010-16039
by ,  and
Int. J. Mol. Sci. 2013, 14(8), 16010-16039; doi:10.3390/ijms140816010
Received: 7 June 2013; in revised form: 15 July 2013 / Accepted: 19 July 2013 / Published: 31 July 2013
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(This article belongs to the Special Issue Regulation by non-coding RNAs)
p. 15681-15694
by ,  and
Int. J. Mol. Sci. 2013, 14(8), 15681-15694; doi:10.3390/ijms140815681
Received: 31 May 2013; in revised form: 21 June 2013 / Accepted: 24 June 2013 / Published: 26 July 2013
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p. 15233-15259
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Int. J. Mol. Sci. 2013, 14(8), 15233-15259; doi:10.3390/ijms140815233
Received: 13 June 2013; in revised form: 1 July 2013 / Accepted: 1 July 2013 / Published: 24 July 2013
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p. 15348-15360
by  and
Int. J. Mol. Sci. 2013, 14(8), 15348-15360; doi:10.3390/ijms140815348
Received: 30 May 2013; in revised form: 5 July 2013 / Accepted: 9 July 2013 / Published: 24 July 2013
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p. 15386-15422
by , ,  and
Int. J. Mol. Sci. 2013, 14(8), 15386-15422; doi:10.3390/ijms140815386
Received: 31 May 2013; in revised form: 28 June 2013 / Accepted: 9 July 2013 / Published: 24 July 2013
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p. 15423-15458
by ,  and
Int. J. Mol. Sci. 2013, 14(8), 15423-15458; doi:10.3390/ijms140815423
Received: 31 May 2013; in revised form: 16 July 2013 / Accepted: 17 July 2013 / Published: 24 July 2013
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p. 14923-14935
by , ,  and
Int. J. Mol. Sci. 2013, 14(7), 14923-14935; doi:10.3390/ijms140714923
Received: 28 May 2013; in revised form: 1 July 2013 / Accepted: 2 July 2013 / Published: 17 July 2013
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p. 14712-14723
by ,  and
Int. J. Mol. Sci. 2013, 14(7), 14712-14723; doi:10.3390/ijms140714712
Received: 30 May 2013; in revised form: 25 June 2013 / Accepted: 2 July 2013 / Published: 15 July 2013
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p. 14744-14770
by , , ,  and
Int. J. Mol. Sci. 2013, 14(7), 14744-14770; doi:10.3390/ijms140714744
Received: 3 June 2013; in revised form: 5 July 2013 / Accepted: 9 July 2013 / Published: 15 July 2013
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p. 14518-14531
by ,  and
Int. J. Mol. Sci. 2013, 14(7), 14518-14531; doi:10.3390/ijms140714518
Received: 31 May 2013; in revised form: 26 June 2013 / Accepted: 1 July 2013 / Published: 12 July 2013
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p. 14689-14699
by , , ,  and
Int. J. Mol. Sci. 2013, 14(7), 14689-14699; doi:10.3390/ijms140714689
Received: 2 May 2013; in revised form: 24 June 2013 / Accepted: 4 July 2013 / Published: 12 July 2013
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p. 14346-14373
by  and
Int. J. Mol. Sci. 2013, 14(7), 14346-14373; doi:10.3390/ijms140714346
Received: 6 May 2013; in revised form: 25 June 2013 / Accepted: 2 July 2013 / Published: 11 July 2013
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p. 14374-14394
by , , , , ,  and
Int. J. Mol. Sci. 2013, 14(7), 14374-14394; doi:10.3390/ijms140714374
Received: 26 April 2013; in revised form: 25 June 2013 / Accepted: 26 June 2013 / Published: 11 July 2013
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p. 14240-14269
by  and
Int. J. Mol. Sci. 2013, 14(7), 14240-14269; doi:10.3390/ijms140714240
Received: 2 May 2013; in revised form: 14 June 2013 / Accepted: 17 June 2013 / Published: 9 July 2013
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p. 14270-14286
by , , , ,  and
Int. J. Mol. Sci. 2013, 14(7), 14270-14286; doi:10.3390/ijms140714270
Received: 20 May 2013; in revised form: 18 June 2013 / Accepted: 28 June 2013 / Published: 9 July 2013
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p. 13482-13496
by , , , ,  and
Int. J. Mol. Sci. 2013, 14(7), 13482-13496; doi:10.3390/ijms140713482
Received: 30 May 2013; in revised form: 13 June 2013 / Accepted: 19 June 2013 / Published: 27 June 2013
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p. 13542-13558
by , ,  and
Int. J. Mol. Sci. 2013, 14(7), 13542-13558; doi:10.3390/ijms140713542
Received: 31 May 2013; in revised form: 19 June 2013 / Accepted: 20 June 2013 / Published: 27 June 2013
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p. 13231-13240
by , ,  and
Int. J. Mol. Sci. 2013, 14(7), 13231-13240; doi:10.3390/ijms140713231
Received: 27 April 2013; in revised form: 29 May 2013 / Accepted: 17 June 2013 / Published: 26 June 2013
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p. 13307-13328
by  and
Int. J. Mol. Sci. 2013, 14(7), 13307-13328; doi:10.3390/ijms140713307
Received: 20 May 2013; in revised form: 5 June 2013 / Accepted: 5 June 2013 / Published: 26 June 2013
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p. 13078-13092
by  and
Int. J. Mol. Sci. 2013, 14(7), 13078-13092; doi:10.3390/ijms140713078
Received: 7 May 2013; in revised form: 5 June 2013 / Accepted: 6 June 2013 / Published: 25 June 2013
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p. 12273-12296
by , , , , , , ,  and
Int. J. Mol. Sci. 2013, 14(6), 12273-12296; doi:10.3390/ijms140612273
Received: 29 March 2013; in revised form: 14 May 2013 / Accepted: 22 May 2013 / Published: 7 June 2013
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p. 11560-11606
by , , , ,  and
Int. J. Mol. Sci. 2013, 14(6), 11560-11606; doi:10.3390/ijms140611560
Received: 17 April 2013; in revised form: 21 May 2013 / Accepted: 22 May 2013 / Published: 30 May 2013
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p. 11171-11189
by , ,  and
Int. J. Mol. Sci. 2013, 14(6), 11171-11189; doi:10.3390/ijms140611171
Received: 21 March 2013; in revised form: 15 April 2013 / Accepted: 6 May 2013 / Published: 27 May 2013
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p. 11190-11207
by , , , , , , , , , , ,  and
Int. J. Mol. Sci. 2013, 14(6), 11190-11207; doi:10.3390/ijms140611190
Received: 21 March 2013; in revised form: 25 April 2013 / Accepted: 15 May 2013 / Published: 27 May 2013
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p. 9487-9496
by  and
Int. J. Mol. Sci. 2013, 14(5), 9487-9496; doi:10.3390/ijms14059487
Received: 27 March 2013; in revised form: 19 April 2013 / Accepted: 25 April 2013 / Published: 29 April 2013
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p. 8611-8624
by , , , , , , , , ,  and
Int. J. Mol. Sci. 2013, 14(4), 8611-8624; doi:10.3390/ijms14048611
Received: 20 March 2013; in revised form: 15 April 2013 / Accepted: 17 April 2013 / Published: 22 April 2013
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p. 8179-8187
by , , , ,  and
Int. J. Mol. Sci. 2013, 14(4), 8179-8187; doi:10.3390/ijms14048179
Received: 7 January 2013; in revised form: 1 April 2013 / Accepted: 2 April 2013 / Published: 15 April 2013
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p. 4655-4669
by  and
Int. J. Mol. Sci. 2013, 14(3), 4655-4669; doi:10.3390/ijms14034655
Received: 1 November 2012; in revised form: 3 January 2013 / Accepted: 31 January 2013 / Published: 26 February 2013
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p. 4361-4371
by , , ,  and
Int. J. Mol. Sci. 2013, 14(2), 4361-4371; doi:10.3390/ijms14024361
Received: 21 November 2012; in revised form: 6 January 2013 / Accepted: 7 January 2013 / Published: 21 February 2013
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p. 3802-3816
by , , ,  and
Int. J. Mol. Sci. 2013, 14(2), 3802-3816; doi:10.3390/ijms14023802
Received: 24 December 2012; in revised form: 23 January 2013 / Accepted: 4 February 2013 / Published: 8 February 2013
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Last update: 14 November 2014

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