Special Issue "Regulation by non-coding RNAs"
Deadline for manuscript submissions: 30 May 2013
Prof. Dr. Nicholas Delihas
Department of Molecular Genetics and Microbiology, School of Medicine, 158 Life Sciences Building, Stony Brook University, Stony Brook, NY 11794, USA
Phone: +1 631 632 8779
Fax: +1 631 632 9797
Interests: regulation of gene expression by small RNAs; annotation of genes; repetitive sequences in intergenic regions in bacteria
Prof. Dr. Constantinos Stathopoulos
Department of Biochemistry, School of Medicine, University of Patras, 1 Asklipiou st., 26504 Patras, Greece
Phone: +30 2610 997932 (office); +30 2610 997936 (lab)
Fax: +30 2610 969167
Regulatory non-protein-coding RNA genes and their transcripts were first found and characterized in bacteria but encompass all biological kingdoms. The complexity of non-coding RNAs (ncRNAs) in terms of number and types increases with degree of biological development, whereby humans and other primates appear to have the largest number. Many regulatory ncRNAs base-pair to a target RNA or DNA and inhibit target function. Bacterial ncRNA genes largely respond to environmental stress conditions and help protect the organism from adverse conditions. The prokaryotic RNAs are for the most part small (<200 bp) and are commonly referred to as small regulatory RNAs (sRNAs). Eukaryotic RNAs consist of small <200 nt RNAs and large >200 nt (termed lncRNAs). The eukaryotic small RNAs include miRNAs, siRNAs, and piRNAs. miRNAs inhibit mRNA functions and may also be associated with cancer. lncRNAs functions are multifaceted and include epigenetic regulation and animal development. The bacterial and archeal immune system CRISPR, and the eukaryotic piwi-interacting RNAs (piRNA) immune system that inhibits mobile elements in germ line cells both function by via RNA transcript/ target DNA heteroduplex base-pairing are a specific class of RNAs that protect cells from invading transposons/and or viruses. siRNAs function in plant and invertebrate immune systems and protect against viral infections. Additionally, small RNA fragments derived from snoRNAs and tRNAs as well as18 nt RNAs (tiRNAs) derived from eukaryotic transcription start sites may play a role in regulation. Exciting new findings with non-protein coding sequences of the human genome show that a major portion of the genome is transcribed. This provides the possibility that larger numbers of functional RNAs may be found in addition to the several thousand known ones. The precepts of genes and genetic inheritance may have to change to include RNA genes and their transcripts and this would represent a starling change in the principles of molecular genetics.
This special issue of IJMS will be devoted to original papers and reviews of properties and mechanism of action of regulatory non-coding RNAs and will be organized into prokaryotic and eukaryotic RNAs with separate subtopics involving regulatory ncRNAs in plants and animals. There will be a special emphasis on RNAs in humans and their significance to disease formation and will include roles of ncRNAs in neurodegeneration, cancer, diabetes and other diseases.
Prof. Dr. Nicholas Delihas
Prof. Dr. Constantinos Stathopoulos
Similar Special Issues could be found in the following:
Special Issue "Non-Coding RNAs 2012" http://www.mdpi.com/journal/ijms/special_issues/rna_2012
Special Issue "Non-Coding RNAs" http://www.mdpi.com/journal/ijms/special_issues/noncoding_RNAs
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. Papers will be published continuously (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are refereed through a peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed Open Access monthly journal published by MDPI.
- Regulatory RNA
- CRISPR RNA
- regulatory small RNA fragments
Article: Downregulation of miR-17~92 Expression Increase Paclitaxel Sensitivity in Human Ovarian Carcinoma SKOV3-TR30 Cells via BIM Instead of PTEN
Int. J. Mol. Sci. 2013, 14(2), 3802-3816; doi:10.3390/ijms14023802
Received: 24 December 2012; in revised form: 23 January 2013 / Accepted: 4 February 2013 / Published: 8 February 2013| Download PDF Full-text (657 KB) | Download XML Full-text
Int. J. Mol. Sci. 2013, 14(2), 4361-4371; doi:10.3390/ijms14024361
Received: 21 November 2012; in revised form: 6 January 2013 / Accepted: 7 January 2013 / Published: 21 February 2013| Download PDF Full-text (1721 KB) | Download XML Full-text
Review: Long Non-Coding RNA in Cancer
Int. J. Mol. Sci. 2013, 14(3), 4655-4669; doi:10.3390/ijms14034655
Received: 1 November 2012; in revised form: 3 January 2013 / Accepted: 31 January 2013 / Published: 26 February 2013| Download PDF Full-text (250 KB) | Download XML Full-text
Int. J. Mol. Sci. 2013, 14(4), 8179-8187; doi:10.3390/ijms14048179
Received: 7 January 2013; in revised form: 1 April 2013 / Accepted: 2 April 2013 / Published: 15 April 2013| Download PDF Full-text (155 KB) | Download XML Full-text
Int. J. Mol. Sci. 2013, 14(4), 8611-8624; doi:10.3390/ijms14048611
Received: 20 March 2013; in revised form: 15 April 2013 / Accepted: 17 April 2013 / Published: 22 April 2013| Download PDF Full-text (833 KB) | Download XML Full-text |
Int. J. Mol. Sci. 2013, 14(5), 9487-9496; doi:10.3390/ijms14059487
Received: 27 March 2013; in revised form: 19 April 2013 / Accepted: 25 April 2013 / Published: 29 April 2013| Download PDF Full-text (421 KB)
Last update: 12 November 2012