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Int. J. Mol. Sci. 2016, 17(3), 356; doi:10.3390/ijms17030356

Crosstalk between Long Noncoding RNAs and MicroRNAs in Health and Disease

1
Vascular Biology Center, Medical College of Georgia, Augusta University, Augusta, GA 30912, USA
2
Department of Internal Medicine, Medical College of Georgia, Augusta University, Augusta, GA 30912, USA
3
Department of Biochemistry and Molecular Biology, Medical College of Georgia, Augusta University, Augusta, GA 30912, USA
*
Author to whom correspondence should be addressed.
Academic Editor: Martin Pichler
Received: 2 February 2016 / Revised: 29 February 2016 / Accepted: 2 March 2016 / Published: 11 March 2016
(This article belongs to the Collection Regulation by Non-Coding RNAs)
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Abstract

Protein-coding genes account for only a small part of the human genome; in fact, the vast majority of transcripts are comprised of non-coding RNAs (ncRNAs) including long ncRNAs (lncRNAs) and small ncRNAs, microRNAs (miRs). Accumulating evidence indicates that ncRNAs could play critical roles in regulating many cellular processes which are often implicated in health and disease. For example, ncRNAs are aberrantly expressed in cancers, heart diseases, and many other diseases. LncRNAs and miRs are therefore novel and promising targets to be developed into biomarkers for diagnosis and prognosis as well as treatment options. The interaction between lncRNAs and miRs as well as its pathophysiological significance have recently been reported. Mechanistically, it is believed that lncRNAs exert “sponge-like” effects on various miRs, which subsequently inhibits miR-mediated functions. This crosstalk between two types of ncRNAs frequently contributes to the pathogenesis of the disease. In this review, we provide a summary of the recent studies highlighting the interaction between these ncRNAs and the effects of this interaction on disease pathogenesis and regulation. View Full-Text
Keywords: cancer; chromatin; epigenetic regulation; gene regulation; heart disease; non-coding RNAs cancer; chromatin; epigenetic regulation; gene regulation; heart disease; non-coding RNAs
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Bayoumi, A.S.; Sayed, A.; Broskova, Z.; Teoh, J.-P.; Wilson, J.; Su, H.; Tang, Y.-L.; Kim, I.-M. Crosstalk between Long Noncoding RNAs and MicroRNAs in Health and Disease. Int. J. Mol. Sci. 2016, 17, 356.

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