miRNAs, Melanoma and Microenvironment: An Intricate Network
AbstractmiRNAs are central players in cancer biology and they play a pivotal role in mediating the network communication between tumor cells and their microenvironment. In melanoma, miRNAs can impair or facilitate a wide array of processes, and here we will focus on: the epithelial to mesenchymal transition (EMT), the immune milieu, and metabolism. Multiple miRNAs can affect the EMT process, even at a distance, for example through exosome-mediated mechanisms. miRNAs also strongly act on some components of the immune system, regulating the activity of key elements such as antigen presenting cells, and can facilitate an immune evasive/suppressive phenotype. miRNAs are also involved in the regulation of metabolic processes, specifically in response to hypoxic stimuli where they can mediate the metabolic switch from an oxidative to a glycolytic metabolism. Overall, this review discusses and summarizes recent findings on miRNA regulation in the melanoma tumor microenvironment, analyzing their potential diagnostic and therapeutic applications. View Full-Text
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Romano, G.; Kwong, L.N. miRNAs, Melanoma and Microenvironment: An Intricate Network. Int. J. Mol. Sci. 2017, 18, 2354.
Romano G, Kwong LN. miRNAs, Melanoma and Microenvironment: An Intricate Network. International Journal of Molecular Sciences. 2017; 18(11):2354.Chicago/Turabian Style
Romano, Gabriele; Kwong, Lawrence N. 2017. "miRNAs, Melanoma and Microenvironment: An Intricate Network." Int. J. Mol. Sci. 18, no. 11: 2354.
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