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Int. J. Mol. Sci. 2016, 17(5), 709; doi:10.3390/ijms17050709

Expression and Function of miR-155 in Diseases of the Gastrointestinal Tract

Department of Gastroenterology, the First Affiliated Hospital of Nanchang University, Nanchang 330006, China
These authors contributed equally to this work.
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Author to whom correspondence should be addressed.
Academic Editor: Martin Pichler
Received: 12 April 2016 / Revised: 25 April 2016 / Accepted: 3 May 2016 / Published: 11 May 2016
(This article belongs to the Collection Regulation by Non-Coding RNAs)
View Full-Text   |   Download PDF [400 KB, uploaded 11 May 2016]   |  

Abstract

MicroRNAs (miRNAs) are a type of small noncoding RNA that can regulate the expression of target genes under physiological and pathophysiological conditions. miR-155 is a multifunctional miRNA with inflammation-related and oncogenic roles. In particular, the dysregulation of miR-155 has been strongly implicated in Helicobacter pylori-related gastric disease, inflammatory bowel disease, and colorectal cancer in addition to being involved in molecular changes of important targets and signaling pathways. This review focuses on the expression and function of miR-155 during inflammation and carcinogenesis and its potential use as an effective therapeutic target for certain gastrointestinal diseases. View Full-Text
Keywords: miR-155; H. Pylori; inflammatory bowel disease; colorectal cancer miR-155; H. Pylori; inflammatory bowel disease; colorectal cancer
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Wan, J.; Xia, L.; Xu, W.; Lu, N. Expression and Function of miR-155 in Diseases of the Gastrointestinal Tract. Int. J. Mol. Sci. 2016, 17, 709.

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