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Int. J. Mol. Sci. 2016, 17(10), 1773; doi:10.3390/ijms17101773

miR-155: A Novel Target in Allergic Asthma

Department of Respiratory Medicine, The Second Affiliated Hospital of Jilin University, Changchun 130041, China
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Author to whom correspondence should be addressed.
Academic Editor: Martin Pichler
Received: 14 August 2016 / Revised: 19 October 2016 / Accepted: 20 October 2016 / Published: 24 October 2016
(This article belongs to the Collection Regulation by Non-Coding RNAs)
View Full-Text   |   Download PDF [662 KB, uploaded 24 October 2016]   |  

Abstract

MicroRNAs (miRNAs), a class of small non-coding RNAs of 18–24 nucleotides in length, function to posttranscriptionally regulate protein expression. miR-155 was one of the first identified and, to date, the most studied miRNA, and has been linked to various cellular processes such as modulation of immune responses and oncogenesis. Previous studies have identified miR-155 as a crucial positive regulator of Th1 immune response in autoimmune diseases, but as a suppressor of Th2 immunity in allergic disorders. However, recent studies have found new evidence that miR-155 plays an indispensible role in allergic asthma. This review summarizes the recent findings with respect to miR-155 in immune responses and the underlying mechanisms responsible for miR-155-related allergic diseases, as well as the similarities between miR-155 and glucocorticoids in immunity. View Full-Text
Keywords: miR-155; allergic disease; asthma; immune response; glucocorticoid miR-155; allergic disease; asthma; immune response; glucocorticoid
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Zhou, H.; Li, J.; Gao, P.; Wang, Q.; Zhang, J. miR-155: A Novel Target in Allergic Asthma. Int. J. Mol. Sci. 2016, 17, 1773.

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