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Int. J. Mol. Sci. 2015, 16(8), 19886-19919; doi:10.3390/ijms160819886

Regulatory Roles of Non-Coding RNAs in Colorectal Cancer

Department of Surgical Oncology and General Surgery, First Hospital of China Medical University, 155 North Nanjing Street, Heping District, Shenyang 110001, China
These authors contributed equally to this work.
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Author to whom correspondence should be addressed.
Academic Editor: Mark Richter
Received: 16 July 2015 / Revised: 16 August 2015 / Accepted: 17 August 2015 / Published: 21 August 2015
(This article belongs to the Collection Regulation by Non-Coding RNAs)
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Abstract

Non-coding RNAs (ncRNAs) have recently gained attention because of their involvement in different biological processes. An increasing number of studies have demonstrated that mutations or abnormal expression of ncRNAs are closely associated with various diseases including cancer. The present review is a comprehensive examination of the aberrant regulation of ncRNAs in colorectal cancer (CRC) and a summary of the current findings on ncRNAs, including long ncRNAs, microRNAs, small interfering RNAs, small nucleolar RNAs, small nuclear RNAs, Piwi-interacting RNAs, and circular RNAs. These ncRNAs might become novel biomarkers and targets as well as potential therapeutic tools for the treatment of CRC in the near future and this review may provide important clues for further research on CRC and for the selection of effective therapeutic targets. View Full-Text
Keywords: non-coding RNAs; colorectal cancer; dysregulation; biomarkers; targets non-coding RNAs; colorectal cancer; dysregulation; biomarkers; targets
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Wang, J.; Song, Y.-X.; Ma, B.; Wang, J.-J.; Sun, J.-X.; Chen, X.-W.; Zhao, J.-H.; Yang, Y.-C.; Wang, Z.-N. Regulatory Roles of Non-Coding RNAs in Colorectal Cancer. Int. J. Mol. Sci. 2015, 16, 19886-19919.

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