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Int. J. Mol. Sci. 2017, 18(6), 1178; doi:10.3390/ijms18061178

Dietary Intervention by Phytochemicals and Their Role in Modulating Coding and Non-Coding Genes in Cancer

Research Center for Functional Genomics, Biomedicine and Translational Medicine, University of Medicine and Pharmacy “Iuliu-Hatieganu”, 400012 Cluj-Napoca, Romania
MEDFUTURE-Research Center for Advanced Medicine, University of Medicine and Pharmacy “Iuliu-Hatieganu”, 400012 Cluj-Napoca, Romania
Department of Prosthodontics and Dental Materials, Faculty of Dental Medicine, University of Medicine and Pharmacy “Iuliu Hatieganu”, 23 Marinescu Street, 400012 Cluj-Napoca, Romania
Surgical Clinic II, 4–6 Clinicilor Street, 400006 Cluj-Napoca, Romania
Department of Surgery, University of Medicine and Pharmacy “Iuliu Haţieganu”, 8 Victor Babes Street, 400012 Cluj-Napoca, Romania
Department of Functional Genomics and Experimental Pathology, Oncological Institute “Prof. Dr. Ion Chiricuţă”, 400015 Cluj-Napoca, Romania
Author to whom correspondence should be addressed.
Academic Editor: Martin Pichler
Received: 21 April 2017 / Revised: 20 May 2017 / Accepted: 24 May 2017 / Published: 1 June 2017
(This article belongs to the Collection Regulation by Non-Coding RNAs)
View Full-Text   |   Download PDF [2360 KB, uploaded 15 June 2017]   |  


Phytochemicals are natural compounds synthesized as secondary metabolites in plants, representing an important source of molecules with a wide range of therapeutic applications. These natural agents are important regulators of key pathological processes/conditions, including cancer, as they are able to modulate the expression of coding and non-coding transcripts with an oncogenic or tumour suppressor role. These natural agents are currently exploited for the development of therapeutic strategies alone or in tandem with conventional treatments for cancer. The aim of this paper is to review the recent studies regarding the role of these natural phytochemicals in different processes related to cancer inhibition, including apoptosis activation, angiogenesis and metastasis suppression. From the large palette of phytochemicals we selected epigallocatechin gallate (EGCG), caffeic acid phenethyl ester (CAPE), genistein, morin and kaempferol, due to their increased activity in modulating multiple coding and non-coding genes, targeting the main hallmarks of cancer. View Full-Text
Keywords: phytochemicals; cancer; apoptosis; coding and non-coding RNA; miRNAs phytochemicals; cancer; apoptosis; coding and non-coding RNA; miRNAs

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Budisan, L.; Gulei, D.; Zanoaga, O.M.; Irimie, A.I.; Chira, S.; Braicu, C.; Gherman, C.D.; Berindan-Neagoe, I. Dietary Intervention by Phytochemicals and Their Role in Modulating Coding and Non-Coding Genes in Cancer. Int. J. Mol. Sci. 2017, 18, 1178.

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