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Int. J. Mol. Sci. 2015, 16(2), 3251-3266; doi:10.3390/ijms16023251

Neighboring Gene Regulation by Antisense Long Non-Coding RNAs

1
Department of Biosciences and Nutrition, Karolinska Institutet, Huddinge 14183, Sweden
2
Faculty of Natural Sciences and Mathematics & Doctoral Program in Biomedical Sciences, Universidad del Rosario, Bogotá 11001000, Colombia
*
Author to whom correspondence should be addressed.
Academic Editor: Martin Pichler
Received: 17 November 2014 / Accepted: 22 January 2015 / Published: 3 February 2015
(This article belongs to the Collection Regulation by Non-Coding RNAs)
View Full-Text   |   Download PDF [2251 KB, uploaded 3 February 2015]   |  

Abstract

Antisense transcription, considered until recently as transcriptional noise, is a very common phenomenon in human and eukaryotic transcriptomes, operating in two ways based on whether the antisense RNA acts in cis or in trans. This process can generate long non-coding RNAs (lncRNAs), one of the most diverse classes of cellular transcripts, which have demonstrated multifunctional roles in fundamental biological processes, including embryonic pluripotency, differentiation and development. Antisense lncRNAs have been shown to control nearly every level of gene regulation—pretranscriptional, transcriptional and posttranscriptional—through DNA–RNA, RNA–RNA or protein–RNA interactions. This review is centered on functional studies of antisense lncRNA-mediated regulation of neighboring gene expression. Specifically, it addresses how these transcripts interact with other biological molecules, nucleic acids and proteins, to regulate gene expression through chromatin remodeling at the pretranscriptional level and modulation of transcriptional and post-transcriptional processes by altering the sense mRNA structure or the cellular compartmental distribution, either in the nucleus or the cytoplasm. View Full-Text
Keywords: regulatory RNA; antisense transcription; long non-coding RNAs; gene regulation regulatory RNA; antisense transcription; long non-coding RNAs; gene regulation
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Villegas, V.E.; Zaphiropoulos, P.G. Neighboring Gene Regulation by Antisense Long Non-Coding RNAs. Int. J. Mol. Sci. 2015, 16, 3251-3266.

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