Induction of miR-3648 Upon ER Stress and Its Regulatory Role in Cell Proliferation
AbstractMicroRNAs (miRNAs) play important roles under multiple cellular conditions including endoplasmic reticulum (ER) stress. We found that miR-3648, a human specific microRNA, was induced under ER stress. Moreover, Adenomatous polyposis coli 2 (APC2), a tumor suppressor and a negative regulator of Wnt signaling, was found to be the direct target of miR-3648. Levels of APC2 were downregulated when cells were under ER stress or after overexpressing miR-3648. Inhibition of miR-3648 by antagomir increased APC2 levels and decreased cell proliferation. Conversely, when miR-3648 was overexpressed, APC2 levels were decreased and the cell growth increased. Our data demonstrated that ER stress mediated induction of miR-3648 in human cells, which then downregulated APC2 to increase cell proliferation. View Full-Text
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Rashid, F.; Awan, H.M.; Shah, A.; Chen, L.; Shan, G. Induction of miR-3648 Upon ER Stress and Its Regulatory Role in Cell Proliferation. Int. J. Mol. Sci. 2017, 18, 1375.
Rashid F, Awan HM, Shah A, Chen L, Shan G. Induction of miR-3648 Upon ER Stress and Its Regulatory Role in Cell Proliferation. International Journal of Molecular Sciences. 2017; 18(7):1375.Chicago/Turabian Style
Rashid, Farooq; Awan, Hassaan M.; Shah, Abdullah; Chen, Liang; Shan, Ge. 2017. "Induction of miR-3648 Upon ER Stress and Its Regulatory Role in Cell Proliferation." Int. J. Mol. Sci. 18, no. 7: 1375.
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