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Int. J. Mol. Sci. 2016, 17(12), 1994; doi:10.3390/ijms17121994

Roles of MicroRNA across Prenatal and Postnatal Periods

Biochemistry, Microbiology & Immunology Department, Faculty of Medicine, University of Ottawa, 451 Smyth Road, Ottawa, ON K1H8M5, Canada
These authors contributed equally to this work.
Current address: Labo’Life France, Pescalis, Les Magnys, 79320 Moutiers-sous-Chantemerle, France.
Author to whom correspondence should be addressed.
Academic Editor: Martin Pichler
Received: 16 October 2016 / Revised: 11 November 2016 / Accepted: 17 November 2016 / Published: 28 November 2016
(This article belongs to the Collection Regulation by Non-Coding RNAs)
View Full-Text   |   Download PDF [824 KB, uploaded 28 November 2016]   |  


Communication between mother and offspring in mammals starts at implantation via the maternal–placental–fetal axis, and continues postpartum via milk targeted to the intestinal mucosa. MicroRNAs (miRNAs), short, noncoding single-stranded RNAs, of about 22 nucleotides in length, are actively involved in many developmental and physiological processes. Here we highlight the role of miRNA in the dynamic signaling that guides infant development, starting from implantation of conceptus and persisting through the prenatal and postnatal periods. miRNAs in body fluids, particularly in amniotic fluid, umbilical cord blood, and breast milk may offer new opportunities to investigate physiological and/or pathological molecular mechanisms that portend to open novel research avenues for the identification of noninvasive biomarkers. View Full-Text
Keywords: maternal-offspring crosstalk; microRNA; noninvasive biomarkers; breast milk maternal-offspring crosstalk; microRNA; noninvasive biomarkers; breast milk

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Floris, I.; Kraft, J.D.; Altosaar, I. Roles of MicroRNA across Prenatal and Postnatal Periods. Int. J. Mol. Sci. 2016, 17, 1994.

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