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Int. J. Mol. Sci. 2018, 19(3), 671; https://doi.org/10.3390/ijms19030671

Hippocampal MicroRNAs Respond to Administration of Antidepressant Fluoxetine in Adult Mice

1
Center for Precision Medicine, School of Medicine and School of Biomedical Sciences, Huaqiao University, 668 Jimei Road, Xiamen 361021, China
2
Department of Cell and Developmental Biology, Cornell University Weill Medical College, 1300 York Avenue, Box 60, New York, NY 10065, USA
3
College of Korean Medicine, Dongguk University, Ilsandonggu, Goyangsi 10326, Gyeonggido, Korea
*
Author to whom correspondence should be addressed.
Received: 25 January 2018 / Revised: 23 February 2018 / Accepted: 24 February 2018 / Published: 27 February 2018
(This article belongs to the Collection Regulation by Non-Coding RNAs)
Full-Text   |   PDF [7494 KB, uploaded 27 February 2018]   |  

Abstract

Current antidepressant treatments to anxiety and depression remain inadequate, burdened by a significant percentage of misuse and drug side-effects, due to unclear mechanisms of actions of antidepressants. To better understand the regulatory roles of antidepressant fluoxetine-related drug reactions, we here investigate changes of expression levels of hippocampal microRNAs (miRNAs) after administration of fluoxetine in normal adult mice. We find that 64 miRNAs showed significant changes between fluoxetine treatment and control groups by analyzing 626 mouse miRNAs. Many miRNAs in response to fluoxetine are involved in neural-related signaling pathways by analyzing miRNA-target gene pairs using the Kyoto encyclopedia of genes and genomes (KEGG) and Gene Ontology (GO). Moreover, miRNAs with altered expression are mainly associated with the repression of the dopaminergic synapse signals, which may affect hippocampal function after fluoxetine treatment. Our results demonstrate that a number of miRNAs respond to antidepressants even in normal mice and may affect target gene expression, which supports the safety consideration of inappropriate treatment and off-label use of antidepressant drugs. View Full-Text
Keywords: miRNAs; fluoxetine; antidepressant; depression; hippocampus miRNAs; fluoxetine; antidepressant; depression; hippocampus
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Miao, N.; Jin, J.; Kim, S.-N.; Sun, T. Hippocampal MicroRNAs Respond to Administration of Antidepressant Fluoxetine in Adult Mice. Int. J. Mol. Sci. 2018, 19, 671.

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