Hippocampal MicroRNAs Respond to Administration of Antidepressant Fluoxetine in Adult Mice
AbstractCurrent antidepressant treatments to anxiety and depression remain inadequate, burdened by a significant percentage of misuse and drug side-effects, due to unclear mechanisms of actions of antidepressants. To better understand the regulatory roles of antidepressant fluoxetine-related drug reactions, we here investigate changes of expression levels of hippocampal microRNAs (miRNAs) after administration of fluoxetine in normal adult mice. We find that 64 miRNAs showed significant changes between fluoxetine treatment and control groups by analyzing 626 mouse miRNAs. Many miRNAs in response to fluoxetine are involved in neural-related signaling pathways by analyzing miRNA-target gene pairs using the Kyoto encyclopedia of genes and genomes (KEGG) and Gene Ontology (GO). Moreover, miRNAs with altered expression are mainly associated with the repression of the dopaminergic synapse signals, which may affect hippocampal function after fluoxetine treatment. Our results demonstrate that a number of miRNAs respond to antidepressants even in normal mice and may affect target gene expression, which supports the safety consideration of inappropriate treatment and off-label use of antidepressant drugs. View Full-Text
- Supplementary File 1:
Supplementary (ZIP, 3739 KB)
Scifeed alert for new publicationsNever miss any articles matching your research from any publisher
- Get alerts for new papers matching your research
- Find out the new papers from selected authors
- Updated daily for 49'000+ journals and 6000+ publishers
- Define your Scifeed now
Miao, N.; Jin, J.; Kim, S.-N.; Sun, T. Hippocampal MicroRNAs Respond to Administration of Antidepressant Fluoxetine in Adult Mice. Int. J. Mol. Sci. 2018, 19, 671.
Miao N, Jin J, Kim S-N, Sun T. Hippocampal MicroRNAs Respond to Administration of Antidepressant Fluoxetine in Adult Mice. International Journal of Molecular Sciences. 2018; 19(3):671.Chicago/Turabian Style
Miao, Nan; Jin, Junghee; Kim, Seung-Nam; Sun, Tao. 2018. "Hippocampal MicroRNAs Respond to Administration of Antidepressant Fluoxetine in Adult Mice." Int. J. Mol. Sci. 19, no. 3: 671.
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.