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Int. J. Mol. Sci. 2016, 17(10), 1729; doi:10.3390/ijms17101729

Regulatory Roles of MicroRNAs in Diabetes

1
,
1,2,* and 1,2,*
1
Medical Systems Biology Research Center, School of Medicine, Tsinghua University, Beijing 100084, China
2
National Engineering Research Center for Beijing Biochip Technology, Beijing 102206, China
*
Authors to whom correspondence should be addressed.
Academic Editor: Martin Pichler
Received: 17 August 2016 / Revised: 2 October 2016 / Accepted: 9 October 2016 / Published: 17 October 2016
(This article belongs to the Collection Regulation by Non-Coding RNAs)
View Full-Text   |   Download PDF [602 KB, uploaded 17 October 2016]   |  

Abstract

MicroRNAs (miRNAs), a class of endogenous small noncoding RNAs in eukaryotes, have been recognized as significant regulators of gene expression through post-transcriptional mechanisms. To date, >2000 miRNAs have been identified in the human genome, and they orchestrate a variety of biological and pathological processes. Disruption of miRNA levels correlates with many diseases, including diabetes mellitus, a complex multifactorial metabolic disorder affecting >400 million people worldwide. miRNAs are involved in the pathogenesis of diabetes mellitus by affecting pancreatic β-cell functions, insulin resistance, or both. In this review, we summarize the investigations of the regulatory roles of important miRNAs in diabetes, as well as the potential of circulating miRNAs as diagnostic markers for diabetes mellitus. View Full-Text
Keywords: miRNAs; diabetes; β-cell function; insulin resistance; circulating miRNAs miRNAs; diabetes; β-cell function; insulin resistance; circulating miRNAs
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Feng, J.; Xing, W.; Xie, L. Regulatory Roles of MicroRNAs in Diabetes. Int. J. Mol. Sci. 2016, 17, 1729.

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