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Int. J. Mol. Sci. 2014, 15(8), 13993-14013; doi:10.3390/ijms150813993
Review

Current Status of Long Non-Coding RNAs in Human Cancer with Specific Focus on Colorectal Cancer

1,†
, 2,†
, 3
, 3
 and 1,*
1 Institute of Pathology, Medical University Graz, Auenbruggerplatz 25, A-8036 Graz, Austria 2 Department of Surgery, St John of God Hospital Graz, Marschallgasse 12, A-8020 Graz, Austria 3 Division of Oncology, Medical University Graz, Auenbruggerplatz 15, A-8036 Graz, Austria These authors have contributed equally to this work.
* Author to whom correspondence should be addressed.
Received: 30 June 2014 / Revised: 23 July 2014 / Accepted: 5 August 2014 / Published: 12 August 2014
(This article belongs to the collection Regulation by Non-Coding RNAs)
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Abstract

The latest investigations of long non-coding RNAs (lncRNAs) have revealed their important role in human cancers. LncRNAs are larger than 200 nucleotides in length and fulfill their cellular purpose without being translated into proteins. Though the molecular functions of some lncRNAs have been elucidated, there is still a high number of lncRNAs with unknown or controversial functions. In this review, we provide an overview of different lncRNAs and their role in human cancers. In particular, we emphasize their importance in tumorigenesis of colorectal cancer, the third most common cancer worldwide.
Keywords: colorectal cancer; lncRNA; cancer; molecular tumor pathogenesis colorectal cancer; lncRNA; cancer; molecular tumor pathogenesis
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Smolle, M.; Uranitsch, S.; Gerger, A.; Pichler, M.; Haybaeck, J. Current Status of Long Non-Coding RNAs in Human Cancer with Specific Focus on Colorectal Cancer. Int. J. Mol. Sci. 2014, 15, 13993-14013.

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