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Int. J. Mol. Sci. 2017, 18(7), 1570; doi:10.3390/ijms18071570

Differential miR-346 and miR-582-3p Expression in Association with Selected Maternal and Fetal Complications

1
Department of Obstetrics and Gynecology, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan 704, Taiwan
2
Institute of Clinical Medicine, College of Medicine, National Cheng Kung University, Tainan 704, Taiwan
3
Department of Public Health, College of Medicine, National Cheng-Kung University, Tainan 704, Taiwan
4
Biostatistics Consulting Center, National Cheng Kung University Hospital, Tainan 704, Taiwan
*
Author to whom correspondence should be addressed.
Received: 12 May 2017 / Revised: 27 June 2017 / Accepted: 10 July 2017 / Published: 19 July 2017
(This article belongs to the Collection Regulation by Non-Coding RNAs)
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Abstract

Several miRNAs are expressed in human gestational tissue, and some have been shown to be associated with placental dysfunction and complicated pregnancy outcomes. To investigate the roles of miR-346 and miR-582-3p in adverse obstetric events, we analyzed these 2 miRNAs in three samples (maternal blood, umbilical cord blood and placenta) obtained from pregnant women in four groups, including healthy control (n = 60), preeclampsia (n = 31), preterm delivery (n = 29) and small for gestational age (n = 19) patients. The expression levels of miR-346 and miR-582-3p in all included adverse obstetric outcome groups were significantly higher in the maternal plasma samples but lower in the placenta samples (all p value < 0.05). In addition, the miR-346 expression levels in fetal cord blood were also significantly lower in all of the included adverse obstetric outcome groups (all p < 0.05). Multivariate analysis of the three specimens after adjusting for maternal age and gestational age at delivery gave the same results. In conclusion, aberrant miR-346 and miR-582-3p expression level in pregnancy was associated with multiple maternal and fetal complications. Their differential expression in maternal blood, umbilical cord blood and placenta could be potential biomarkers or therapeutic targets for adverse obstetric outcomes View Full-Text
Keywords: miR-346; miR-582-3p; preeclampsia; preterm delivery; intrauterine growth restriction miR-346; miR-582-3p; preeclampsia; preterm delivery; intrauterine growth restriction
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Tsai, P.-Y.; Li, S.-H.; Chen, W.-N.; Tsai, H.-L.; Su, M.-T. Differential miR-346 and miR-582-3p Expression in Association with Selected Maternal and Fetal Complications. Int. J. Mol. Sci. 2017, 18, 1570.

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