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Int. J. Mol. Sci. 2014, 15(11), 20434-20448; doi:10.3390/ijms151120434

Long Non-Coding RNAs: Critical Players in Hepatocellular Carcinoma

1
,
1
,
1,2
,
1,3
and
1,2,*
1
National-Local Joint Engineering Research Center of Biodiagnostics and Biotherapy, Xi'an Jiaotong University, Xi'an 710004, China
2
Department of General Surgery, the Second Affiliated Hospital, School of Medicine, Xi'an Jiaotong University, Xi'an 710004, China
3
Department of Pathology, the Second Affiliated Hospital, School of Medicine, Xi'an Jiaotong University, Xi'an 710004, China
*
Author to whom correspondence should be addressed.
Received: 17 September 2014 / Revised: 30 October 2014 / Accepted: 30 October 2014 / Published: 7 November 2014
(This article belongs to the Collection Regulation by Non-Coding RNAs)
View Full-Text   |   Download PDF [1408 KB, uploaded 7 November 2014]   |  

Abstract

Hepatocellular carcinoma (HCC) is a complex disease with multiple underlying pathogenic mechanisms caused by a variety of etiologic factors. Emerging evidence showed that long non-coding RNAs (lncRNAs), with size larger than 200 nucleotides (nt), play important roles in various types of cancer development and progression. In recent years, some dysregulated lncRNAs in HCC have been revealed and roles for several of them in HCC have been characterized. All these findings point to the potential of lncRNAs as prospective novel therapeutic targets in HCC. In this review, we summarize known dysregulated lncRNAs in HCC, and review potential biological roles and underlying molecular mechanisms of lncRNAs in HCC. Additionally, we discussed prospects of lncRNAs as potential biomarker and therapeutic target for HCC. In conclusion, this paper will help us gain better understanding of molecular mechanisms by which lncRNAs perform their function in HCC and also provide general strategies and directions for future research. View Full-Text
Keywords: long noncoding RNA; hepatocellular carcinoma; dysregulation; biological roles; molecular mechanism long noncoding RNA; hepatocellular carcinoma; dysregulation; biological roles; molecular mechanism
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Sun, J.; Bie, B.; Zhang, S.; Yang, J.; Li, Z. Long Non-Coding RNAs: Critical Players in Hepatocellular Carcinoma. Int. J. Mol. Sci. 2014, 15, 20434-20448.

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