dFmr1 Plays Roles in Small RNA Pathways of Drosophila melanogaster
AbstractFragile-X syndrome is the most common form of inherited mental retardation accompanied by other phenotypes, including macroorchidism. The disorder originates with mutations in the Fmr1 gene coding for the FMRP protein, which, with its paralogs FXR1 and FXR2, constitute a well-conserved family of RNA-binding proteins. Drosophila melanogaster is a good model for the syndrome because it has a unique fragile X-related gene: dFmr1. Recently, in addition to its confirmed role in the miRNA pathway, a function for dFmr1 in the piRNA pathway, operating in Drosophila gonads, has been established. In this review we report a summary of the piRNA pathways occurring in gonads with a special emphasis on the relationship between the piRNA genes and the crystal-Stellate system; we also analyze the roles of dFmr1 in the Drosophila gonads, exploring their genetic and biochemical interactions to reveal some unexpected connections. View Full-Text
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Specchia, V.; D’Attis, S.; Puricella, A.; Bozzetti, M.P. dFmr1 Plays Roles in Small RNA Pathways of Drosophila melanogaster. Int. J. Mol. Sci. 2017, 18, 1066.
Specchia V, D’Attis S, Puricella A, Bozzetti MP. dFmr1 Plays Roles in Small RNA Pathways of Drosophila melanogaster. International Journal of Molecular Sciences. 2017; 18(5):1066.Chicago/Turabian Style
Specchia, Valeria; D’Attis, Simona; Puricella, Antonietta; Bozzetti, Maria P. 2017. "dFmr1 Plays Roles in Small RNA Pathways of Drosophila melanogaster." Int. J. Mol. Sci. 18, no. 5: 1066.
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