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Int. J. Mol. Sci. 2016, 17(4), 478; doi:10.3390/ijms17040478

Novel Insights into the Role of Long Noncoding RNA in Ocular Diseases

Department of Ophthalmology, Ninth People’s Hospital, School of Medicine, Shanghai JiaoTong University, Shanghai 200025, China
These authors contributed equally to this work.
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Authors to whom correspondence should be addressed.
Academic Editor: Martin Pichler
Received: 11 February 2016 / Revised: 18 March 2016 / Accepted: 18 March 2016 / Published: 31 March 2016
(This article belongs to the Collection Regulation by Non-Coding RNAs)
View Full-Text   |   Download PDF [217 KB, uploaded 31 March 2016]   |  

Abstract

Recent advances have suggested that long noncoding RNAs (lncRNAs) are differentially expressed in ocular tissues and play a critical role in the pathogenesis of different types of eye diseases. Here, we summarize the functions and mechanisms of known aberrantly-expressed lncRNAs and present a brief overview of relevant reports about lncRNAs in such ocular diseases as glaucoma, proliferative vitreoretinopathy (PVR), diabeticretinopathy (DR), and ocular tumors. We intend to highlight comprehensive studies that provide detailed data about the mechanisms of lncRNAs, their applications as diagnostic or prognostic biomarkers, and their potential therapeutic targets. Although our understanding of lncRNAs is still in its infancy, these examples may provide helpful insights into the methods by which lncRNAs interfere with ocular diseases. View Full-Text
Keywords: epigenetics; long noncoding RNA; ocular disease epigenetics; long noncoding RNA; ocular disease
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Li, F.; Wen, X.; Zhang, H.; Fan, X. Novel Insights into the Role of Long Noncoding RNA in Ocular Diseases. Int. J. Mol. Sci. 2016, 17, 478.

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