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Int. J. Mol. Sci. 2017, 18(11), 2319; https://doi.org/10.3390/ijms18112319

Regulation of Human Breast Cancer by the Long Non-Coding RNA H19

1
INSERM U908, 59655 Villeneuve d’Ascq, France
2
University of Lille, 59655 Villeneuve d’Ascq, France
*
Author to whom correspondence should be addressed.
Received: 3 October 2017 / Revised: 27 October 2017 / Accepted: 30 October 2017 / Published: 3 November 2017
(This article belongs to the Collection Regulation by Non-Coding RNAs)
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Abstract

Breast cancer is one of the most common causes of cancer related deaths in women. Despite the progress in early detection and use of new therapeutic targets associated with development of novel therapeutic options, breast cancer remains a major problem in public health. Indeed, even if the survival rate has improved for breast cancer patients, the number of recurrences within five years and the five-year relative survival rate in patients with metastasis remain dramatic. Thus, the discovery of new molecular actors involved in breast progression is essential to improve the management of this disease. Numerous data indicate that long non-coding RNA are implicated in breast cancer development. The oncofetal lncRNA H19 was the first RNA identified as a riboregulator. Studying of this lncRNA revealed its implication in both normal development and diseases. In this review, we summarize the different mechanisms of action of H19 in human breast cancer. View Full-Text
Keywords: lncRNA; H19; breast cancer; non-coding RNA lncRNA; H19; breast cancer; non-coding RNA
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Collette, J.; Le Bourhis, X.; Adriaenssens, E. Regulation of Human Breast Cancer by the Long Non-Coding RNA H19. Int. J. Mol. Sci. 2017, 18, 2319.

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