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Int. J. Mol. Sci. 2015, 16(3), 5467-5496; doi:10.3390/ijms16035467

Exploring the Secrets of Long Noncoding RNAs

1
National Engineering Laboratory for Tree Breeding, College of Biological Sciences and Technology, Beijing Forestry University, Beijing 100083, China
2
Key Laboratory of Genetics and Breeding in Forest Trees and Ornamental Plants, Ministry of Education, College of Biological Sciences and Technology, Beijing Forestry University, Beijing 100083, China
*
Author to whom correspondence should be addressed.
Academic Editor: Martin Pichler
Received: 12 December 2014 / Revised: 22 February 2015 / Accepted: 3 March 2015 / Published: 10 March 2015
(This article belongs to the Collection Regulation by Non-Coding RNAs)
View Full-Text   |   Download PDF [1688 KB, uploaded 10 March 2015]   |  

Abstract

High-throughput sequencing has revealed that the majority of RNAs have no capacity to encode protein. Among these non-coding transcripts, recent work has focused on the roles of long noncoding RNAs (lncRNAs) of >200 nucleotides. Although many of their attributes, such as patterns of expression, remain largely unknown, lncRNAs have key functions in transcriptional, post-transcriptional, and epigenetic gene regulation; Also, new work indicates their functions in scaffolding ribonuclear protein complexes. In plants, genome-wide identification of lncRNAs has been conducted in several species, including Zea mays, and recent research showed that lncRNAs regulate flowering time in the photoperiod pathway, and function in nodulation. In this review, we discuss the basic mechanisms by which lncRNAs regulate key cellular processes, using the large body of knowledge on animal and yeast lncRNAs to illustrate the significance of emerging work on lncRNAs in plants. View Full-Text
Keywords: lncRNAs; functional genomics; transcriptional regulation; post-transcriptional regulation; epigenetics; lncRNAs in plants lncRNAs; functional genomics; transcriptional regulation; post-transcriptional regulation; epigenetics; lncRNAs in plants
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Quan, M.; Chen, J.; Zhang, D. Exploring the Secrets of Long Noncoding RNAs. Int. J. Mol. Sci. 2015, 16, 5467-5496.

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