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Int. J. Mol. Sci. 2015, 16(7), 16593-16621; doi:10.3390/ijms160716593

What Do We Know about the Role of miRNAs in Pediatric Sarcoma?

1
The National Children's Research Centre, Lady's Children's Hospital, Crumlin, Dublin 12, Ireland
2
Histology Laboratory, Lady's Children's Hospital, Crumlin, Dublin 12, Ireland
3
Trinity College, University of Dublin, Dublin 2, Ireland
*
Author to whom correspondence should be addressed.
Academic Editor: Martin Pichler
Received: 29 May 2015 / Revised: 10 July 2015 / Accepted: 15 July 2015 / Published: 22 July 2015
(This article belongs to the Collection Regulation by Non-Coding RNAs)
View Full-Text   |   Download PDF [870 KB, uploaded 22 July 2015]   |  

Abstract

Non-coding RNAs have received a lot of attention in recent years, with especial focus on microRNAs (miRNAs), so much so that in the just over two decades since the first miRNA, Lin4, was described, almost 40,000 publications about miRNAs have been generated. Less than 500 of these focus on sarcoma, and only a fraction of those on sarcomas of childhood specifically, with some of these representing observational studies and others containing functionally validated data. This is a group of cancers for which prognosis is often poor and therapeutic options limited, and it is especially in these areas that strides in understanding the role of non-coding RNAs and miRNAs in particular are to be welcomed. This review deals with the main forms of pediatric sarcoma, exploring what is known about the diagnostic and prognostic profiles of miRNAs in these tumours and where novel therapeutic options might present themselves for further exploration. View Full-Text
Keywords: microRNA; regulation of gene expression; pediatric; sarcoma microRNA; regulation of gene expression; pediatric; sarcoma
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Kelly, L.C.; Lázaro, A.; O'Sullivan, M.J. What Do We Know about the Role of miRNAs in Pediatric Sarcoma? Int. J. Mol. Sci. 2015, 16, 16593-16621.

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