LincRNA-p21: Implications in Human Diseases
AbstractLong noncoding RNAs (lncRNAs), which lack significant protein-coding capacity, regulate various biological processes through diverse and as yet poorly understood molecular mechanisms. However, a number of studies in the past few years have documented important functions for lncRNAs in human diseases. Among these lncRNAs, lincRNA-p21 has been proposed to be a novel regulator of cell proliferation, apoptosis and DNA damage response, and involved in the initiation and progression of human diseases. In this review, we summarize the current knowledge of lincRNA-p21, mainly focus on the known biological functions and its underlying mechanisms. Moreover, we highlight the growing body of evidences for the importance of lincRNA-p21 in diverse human diseases, which indicate lincRNA-p21 as a potential diagnostic marker and/or a valuable therapeutic target for these diseases. View Full-Text
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Tang, S.-S.; Zheng, B.-Y.; Xiong, X.-D. LincRNA-p21: Implications in Human Diseases. Int. J. Mol. Sci. 2015, 16, 18732-18740.
Tang S-S, Zheng B-Y, Xiong X-D. LincRNA-p21: Implications in Human Diseases. International Journal of Molecular Sciences. 2015; 16(8):18732-18740.Chicago/Turabian Style
Tang, Sai-Sai; Zheng, Bi-Ying; Xiong, Xing-Dong. 2015. "LincRNA-p21: Implications in Human Diseases." Int. J. Mol. Sci. 16, no. 8: 18732-18740.