Next Article in Journal
In Vitro Expansion of CAG, CAA, and Mixed CAG/CAA Repeats
Next Article in Special Issue
Regulatory Roles of Non-Coding RNAs in Colorectal Cancer
Previous Article in Journal
Formation of Chlorotriophenoxy Radicals from Complete Series Reactions of Chlorotriophenols with H and OH Radicals
Previous Article in Special Issue
miR-199a and miR-497 Are Associated with Better Overall Survival due to Increased Chemosensitivity in Diffuse Large B-Cell Lymphoma Patients
Article Menu
Issue 8 (August) cover image

Export Article

Open AccessReview
Int. J. Mol. Sci. 2015, 16(8), 18732-18740; doi:10.3390/ijms160818732

LincRNA-p21: Implications in Human Diseases

1
Institute of Aging Research, Guangdong Medical University, Dongguan 523808, China
2
Institute of Biochemistry & Molecular Biology, Guangdong Medical University, Zhanjiang 524023, China
3
Key Laboratory for Medical Molecular Diagnostics of Guangdong Province, Guangdong Medical University, Dongguan 523808, China
4
Institute of Laboratory Medicine, Guangdong Medical University, Dongguan 523808, China
5
Department of Pharmacology and the Penn State Hershey Cancer Institute, Milton S. Hershey Medical Center, the Pennsylvania State University College of Medicine, Hershey, PA 17033, USA
*
Author to whom correspondence should be addressed.
Academic Editor: Martin Pichler
Received: 4 July 2015 / Revised: 4 July 2015 / Accepted: 4 August 2015 / Published: 11 August 2015
(This article belongs to the Collection Regulation by Non-Coding RNAs)
View Full-Text   |   Download PDF [979 KB, uploaded 11 August 2015]   |  

Abstract

Long noncoding RNAs (lncRNAs), which lack significant protein-coding capacity, regulate various biological processes through diverse and as yet poorly understood molecular mechanisms. However, a number of studies in the past few years have documented important functions for lncRNAs in human diseases. Among these lncRNAs, lincRNA-p21 has been proposed to be a novel regulator of cell proliferation, apoptosis and DNA damage response, and involved in the initiation and progression of human diseases. In this review, we summarize the current knowledge of lincRNA-p21, mainly focus on the known biological functions and its underlying mechanisms. Moreover, we highlight the growing body of evidences for the importance of lincRNA-p21 in diverse human diseases, which indicate lincRNA-p21 as a potential diagnostic marker and/or a valuable therapeutic target for these diseases. View Full-Text
Keywords: long non-coding RNA; lincRNA-p21; gene regulation; diseases long non-coding RNA; lincRNA-p21; gene regulation; diseases
Figures

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Tang, S.-S.; Zheng, B.-Y.; Xiong, X.-D. LincRNA-p21: Implications in Human Diseases. Int. J. Mol. Sci. 2015, 16, 18732-18740.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top