Int. J. Mol. Sci. 2014, 15(9), 15700-15733; doi:10.3390/ijms150915700
Multistep Model of Cervical Cancer: Participation of miRNAs and Coding Genes
1
Laboratorio de microRNAs, Unidad Académica de Ciencias Biológicas, Universidad Autónoma de Zacatecas, Av. Preparatoria S/N, Zacatecas 98066, Mexico
2
Académica de Ciencias Básicas, Doctorado de Ciencias Básicas, Universidad Autónoma de Zacatecas, Av. Preparatoria S/N, Campus II, Zacatecas 98066, Mexico
*
Author to whom correspondence should be addressed.
Received: 20 June 2014 / Revised: 5 August 2014 / Accepted: 13 August 2014 / Published: 4 September 2014
(This article belongs to the Collection Regulation by Non-Coding RNAs)
Abstract
Aberrant miRNA expression is well recognized as an important step in the development of cancer. Close to 70 microRNAs (miRNAs) have been implicated in cervical cancer up to now, nevertheless it is unknown if aberrant miRNA expression causes the onset of cervical cancer. One of the best ways to address this issue is through a multistep model of carcinogenesis. In the progression of cervical cancer there are three well-established steps to reach cancer that we used in the model proposed here. The first step of the model comprises the gene changes that occur in normal cells to be transformed into immortal cells (CIN 1), the second comprises immortal cell changes to tumorigenic cells (CIN 2), the third step includes cell changes to increase tumorigenic capacity (CIN 3), and the final step covers tumorigenic changes to carcinogenic cells. Altered miRNAs and their target genes are located in each one of the four steps of the multistep model of carcinogenesis. miRNA expression has shown discrepancies in different works; therefore, in this model we include miRNAs recording similar results in at least two studies. The present model is a useful insight into studying potential prognostic, diagnostic, and therapeutic miRNAs. View Full-Text
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Granados López, A.J.; López, J.A. Multistep Model of Cervical Cancer: Participation of miRNAs and Coding Genes. Int. J. Mol. Sci. 2014, 15, 15700-15733.
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