Protein fouling can significantly reduce the filtrate flux, capacity, and virus retention during processing of plasma- or mammalian cell-derived biopharmaceuticals through virus removal filters. We use focused ion beam (FIB) milling and scanning elec...
Coagulation Factor IX-rich protrhombin complex concentrate (FIX-PCC) is a therapeutic biologic product that consists of a mixture of several human plasma-derived proteins, useful for treating hemophilia B. Due to its complex composition, FIX-PCC is v...
Pressure-dependent breakthrough of nanobioparticles in filtration was observed and it was related to depend on both convective forces due to flow and diffusion as a result of Brownian motion. The aim of this work was to investigate the significance o...
This study is dedicated to the rapid removal of protein aggregates and viruses from plasma-derived human serum albumin (HSA) product to reduce the risk of viral contamination and increase biosafety. A two-step filtration approach was implemented to f...
Viruses are major contributors to the annual 1.3 million deaths associated with the global burden of diarrheal disease morbidity and mortality. While household-level water treatment technologies reduce diarrheal illness, the majority of filtration te...
Waterborne viruses are a public health concern due to relatively small infection doses. Particularly, adenoviruses (AdVs) are more resistant than RNA viruses to water purification treatments in terms of ultraviolet (UV) irradiation, pH, and chlorinat...
Point-of-use ceramic filters are one of the strategies to address problems associated with waterborne diseases to remove harmful microorganisms in water sources prior to its consumption. In this study, development of adsorption-based ceramic depth fi...
27 February 2016
The use of porous ceramic filters is promoted globally for household water treatment, but these filters are ineffective in removing viruses from water. In order to increase virus removal, we combine a promising natural coagulant, chitosan, as a pretr...
Regulatory authorities place stringent guidelines on the removal of contaminants during the manufacture of biopharmaceutical products. Monoclonal antibodies, Fc-fusion proteins, and other mammalian cell-derived biotherapeutics are heterogeneous molec...
Pore-size distribution (PSD) is the most critical parameter for size-exclusion virus removal filters. Yet, different dry- and wet-state porometry methods yield different pore-size values. The goal of this work is to conduct comparative analysis of ni...
The World Health Organization (WHO) reports that two billion people worldwide lack access to safely managed water sources, including 1.2 billion who already have access to improved water sources. In many countries, household point-of-use (POU) water-...
Groundwater depletion is a critical agricultural irrigation issue, which can be mitigated by supplementation with water of higher microbiological risk, including surface and reclaimed waters, to support irrigation needs in the United States. Zero-val...
Size- and time-dependent particle removal efficiency (PRE) of different protective respiratory masks were determined using a standard aerosol powder with the size of particles in the range of an uncoated SARS-CoV-2 virus and small respiratory droplet...
25 August 2015
The biosand filter (BSF) is an intermittently operated, household-scale slow sand filter for which little data are available on the effect of sand composition on treatment performance. Therefore, bench-scale columns were prepared according to the the...
Point-of-use biosand water filters are widely distributed in undeveloped or developing regions due to their water treatment success and low-cost design, but two gaps remain in the basic technology: (1) the filter body is oversized relative to its con...
Steric exclusion chromatography (SXC) is a promising purification method for biological macromolecules such as the Orf virus (ORFV) vector. The method’s principle is closely related to conventional polyethylene glycol (PEG) precipitation, repea...
Enteric viruses in wastewater remain a persistent public health threat. Conventional treatments often achieve only modest viral log10 reductions and can generate toxic disinfection byproducts, but high-energy advanced processes are often unaffordable...
Flow virometry (FVM) offers a promising approach for monitoring viruses and virus-like particles (VLPs) in environmental samples. This study compares levels of non-specific VLPs across a wastewater treatment plant (WWTP) with levels of somatic coliph...
New influenza strains are constantly emerging, causing seasonal epidemics and raising concerns to the risk of a new global pandemic. Since vaccination is an effective method to prevent the spread of the disease and reduce its severity, the developmen...
Aims: Indoor air quality (IAQ) has attracted increased attention with the emergence of COVID-19. Ventilation is perhaps the area in which the most changes have been proposed in response to the emergency caused by this virus. However, other strategies...
In urban public transportation and highly diversified air environments, air pollutant exposure is becoming an increasing concern in terms of public health and personal safety. Herein, the scientific literature on air quality and virus transmission in...
3 January 2023
SARS-CoV-2 genetic sequence results collected from native COVID-19 cases who waited or saw relatives off at Xi’an Xianyang International Airport were highly consistent with the imported cases. In order to explore the routes of transmission and...
Adeno-associated viruses (AAV) are currently predominant viral transfer tools for gene therapy, and efforts are being made to design faster and more efficient methods and technologies for their manufacturing. The early selection of high-performing fi...
The COVID-19 pandemic highlighted the need for a scientific framework that enables quantitative assessment and control of airborne infection risks in indoor environments. This study identifies limitations in the traditional Wells–Riley model&md...
An Advanced Water Treatment Plant (AWTP) for potable water recycling in Davis Station Antarctica was trialed using secondary effluent at Selfs Point in Hobart, Tasmania, for nine months. The trials demonstrated the reliability of performance of a sev...