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136 Results Found

  • Article
  • Open Access
4 Citations
5,433 Views
14 Pages

Long-Term Management of Post-Stroke Spasticity with Botulinum Toxin: A Retrospective Study

  • Nicoletta Falcone,
  • Fabrizio Leo,
  • Carmelo Chisari and
  • Stefania Dalise

3 September 2024

Stroke-induced spasticity is a prevalent condition affecting stroke survivors, significantly impacting their quality of life. Botulinum Toxin A injections are widely used for its management, yet the long-term effects and optimal management strategies...

  • Review
  • Open Access
37 Citations
13,779 Views
29 Pages

8 November 2022

Spasticity, following the neurological disorder of cerebral palsy (CP), describes a pathological condition, the central feature of which is involuntary and prolonged muscle contraction. The persistent resistance of spastic muscles to stretching is of...

  • Review
  • Open Access
5 Citations
5,808 Views
13 Pages

Focal Vibration Therapy for Motor Deficits and Spasticity Management in Post-Stroke Rehabilitation

  • Federica Giorgi,
  • Danilo Donati,
  • Daniela Platano and
  • Roberto Tedeschi

25 October 2024

Background: Focal mechanical vibration therapy has gained attention as a potential intervention to improve motor function while decreasing spasticity and pain in post-stroke patients. Despite promising results, there remains variability in study desi...

  • Review
  • Open Access
7 Citations
7,585 Views
15 Pages

Long-Term Spasticity Management in Post-Stroke Patients: Issues and Possible Actions—A Systematic Review with an Italian Expert Opinion

  • Giovanni Morone,
  • Alessio Baricich,
  • Stefano Paolucci,
  • Anna Rita Bentivoglio,
  • Paolo De Blasiis,
  • Matilde Carlucci,
  • Francesco Violi,
  • Gabriella Levato,
  • Marcello Pani and
  • Nicola Smania
  • + 3 authors

Spasticity is a well-known motor dysfunction occurring after a stroke. A group of Italian physicians’ experts in treating post-stroke spasticity (PSS) reviewed the current scientific evidence concerning the state-of-the-art clinical management...

  • Review
  • Open Access
30 Citations
8,448 Views
11 Pages

Spasticity Management in Disorders of Consciousness

  • Géraldine Martens,
  • Steven Laureys and
  • Aurore Thibaut

9 December 2017

Background: Spasticity is a motor disorder frequently encountered after a lesion involving the central nervous system. It is hypothesized to arise from an anarchic reorganization of the pyramidal and parapyramidal fibers and leads to hypertonia and h...

  • Article
  • Open Access
1 Citations
2,354 Views
16 Pages

Switox: Retrospective Analysis of Botulinum Toxin Switching in Management of Spasticity

  • Emilie Leblong,
  • Patrice Piette,
  • Carole Anne,
  • Maud Jeanne,
  • Marion Poyau,
  • Anne Laure Roy and
  • Philippe Gallien

24 February 2025

This retrospective study investigates botulinum toxin changes in 206 patients with spasticity, following reimbursement adjustments in France. The main objective was to evaluate the tolerance and efficacy of these changes, a topic underexplored due to...

  • Article
  • Open Access
30 Citations
10,160 Views
12 Pages

Spasticity Management after Spinal Cord Injury: The Here and Now

  • Zackery J. Billington,
  • Austin M. Henke and
  • David R. Gater

Spasticity is a common comorbidity of spinal cord injury (SCI) that is characterized by velocity dependent tone and spasms manifested by uninhibited reflex activity of muscles below the level of injury. For some, spasticity can be beneficial and faci...

  • Systematic Review
  • Open Access
2 Citations
2,842 Views
22 Pages

OnabotulinumtoxinA in the Management of Pain in Adult Patients with Spasticity: A Systematic Literature Review

  • Francesca Bianchi,
  • Mariana Nelson,
  • Jörg Wissel,
  • Heakyung Kim,
  • Alexandra Traut,
  • Darshini Shah,
  • Tiziana Musacchio and
  • Bahman Jabbari

18 August 2025

Many patients with spasticity report pain which can be debilitating. Numerous studies have shown onabotulinumtoxinA (onabotA) is efficacious in the management of spasticity but comprehensive data on its impact on spasticity-associated pain is limited...

  • Opinion
  • Open Access
4 Citations
4,965 Views
6 Pages

7 November 2024

Botulinum toxin type A is a first-line treatment for post-stroke spasticity, with selective action at nerve endings and minimal effects beyond the injection site. However, concerns about potential adverse reactions due to toxin diffusion and spread c...

  • Article
  • Open Access
4 Citations
1,968 Views
14 Pages

Integrating Telemedicine in Botulinum Toxin Type-A Treatment for Spasticity Management: Perspectives and Challenges from Italian Healthcare Professionals

  • Stefania Spina,
  • Salvatore Facciorusso,
  • Nicoletta Cinone,
  • Luigi Santoro,
  • Anna Castagna,
  • Marina Ramella,
  • Franco Molteni,
  • Andrea Santamato and
  • The Collaborative Working Group

7 December 2024

(1) Background: Telemedicine is a vital tool for enhancing healthcare accessibility and outcomes at reduced costs. This study aimed to assess the usability of the Maia Connected Care telemedicine platform for managing spasticity in patients receiving...

  • Review
  • Open Access
42 Citations
25,462 Views
21 Pages

Best Practice Guidelines for the Management of Patients with Post-Stroke Spasticity: A Modified Scoping Review

  • Areerat Suputtitada,
  • Supattana Chatromyen,
  • Carl P. C. Chen and
  • David M. Simpson

10 February 2024

This article aims to provide a concise overview of the best available evidence for managing post-stroke spasticity. A modified scoping review, conducted following the PRISMA guidelines and the PRISMA Extension for Scoping Reviews (PRISMA-ScR), involv...

  • Review
  • Open Access
10 Citations
13,835 Views
25 Pages

Pathophysiology and Management Strategies for Post-Stroke Spasticity: An Update Review

  • Bei Chen,
  • Tong Yang,
  • Zi Liao,
  • Feiyue Sun,
  • Zhigang Mei and
  • Wenli Zhang

Post-stroke spasticity (PSS), characterized by a velocity-dependent increase in muscle tone and exaggerated reflexes, affects a significant portion of stroke patients and presents a substantial obstacle to post-stroke rehabilitation. Effective manage...

  • Review
  • Open Access
28 Citations
6,658 Views
26 Pages

12 January 2021

In many patients after stroke, spasticity develops over time, resulting in a decrease in the patient’s independence, pain, worsening mood, and, consequently, lower quality of life. In the last ten years, a rich arsenal of physical agents to red...

  • Article
  • Open Access
999 Views
16 Pages

9 May 2025

Spasticity, characterized by elevated muscle tone, is commonly managed with botulinum toxin type A (BTX-A). However, BTX-A can paradoxically increase passive muscle forces, narrow muscles’ length range of force exertion (lrange), and elevate ex...

  • Systematic Review
  • Open Access
1 Citations
5,708 Views
19 Pages

Efficacy and Immunological Impact of Intrathecal Baclofen Pumps in Managing Spasticity in Multiple Sclerosis in Adult Patients: A Systematic Review

  • Billy McBenedict,
  • Wilhelmina Hauwanga,
  • Anna Pogodina,
  • Jeshua Nathaniel Devan,
  • Kang Suen Goh,
  • Ryan Chun Chien Yau,
  • Berley Alphonse,
  • Lorena Adolphsson and
  • Bruno Lima Pessôa

Background/Objectives: Multiple sclerosis (MS) is a chronic autoimmune disease marked by inflammatory demyelination in the central nervous system, leading to debilitating spasticity. Managing spasticity in MS remains a challenge, and intrathecal bacl...

  • Systematic Review
  • Open Access
1,848 Views
11 Pages

Multiple Sclerosis: Enhancing Botulinum Toxin Effects in Spasticity Management, a Systematic Review

  • Daniela Poenaru,
  • Miruna Ioana Sandulescu,
  • Catalin Furculescu and
  • Claudia Gabriela Potcovaru

24 July 2025

Background/Objectives: The objective of this review is to document the modalities to enhance the neuromuscular effects of botulinum toxin (BoNT) injection in spastic patients with multiple sclerosis (MS). Methods: We conducted a literature review foc...

  • Case Report
  • Open Access
3,343 Views
13 Pages

Challenges of Hip Arthroplasty in a Paretic, Spastic Limb: A Case Study on Managing Femoral Neck Fracture Following Fixation Failure in a Hemiparetic Patient

  • Izabela Dąbkowska,
  • Lena Sobiech,
  • Michał Merkisz,
  • Karolina Turżańska,
  • Tomasz Blicharski and
  • Katarzyna Jankiewicz

10 July 2024

Background: Hip fractures and strokes are prevalent and escalating issues in geriatric healthcare. The absence of standardized surgical protocols for patients with spastic hemiparesis and multiple comorbidities presents a significant medical challeng...

  • Communication
  • Open Access
859 Views
12 Pages

Artificial Intelligence in Managing Spasticity with Botulinum Toxin Type A—Insights from an Exploratory Pilot Investigation: The AIMS Study

  • Mirko Filippetti,
  • Rita Di Censo,
  • Lyria Arcari,
  • Maria Concetta Schiavariello,
  • Marco Battaglia,
  • Salvatore Facciorusso,
  • Stefania Spina,
  • Laura Antonucci,
  • Andrea Santamato and
  • Alessandro Picelli
  • + 2 authors

27 November 2025

This study aimed to explore the potential role of artificial intelligence in optimizing botulinum toxin type A treatment for spasticity and to evaluate its alignment with expert clinical decisions. A comparative analysis was conducted using thirty hy...

  • Article
  • Open Access
4 Citations
4,066 Views
15 Pages

Management of Upper-Limb Spasticity Using Modern Rehabilitation Techniques versus Botulinum Toxin Injections Following Stroke

  • Ana Maria Bumbea,
  • Otilia Constantina Rogoveanu,
  • Adina Turcu-Stiolica,
  • Ionica Pirici,
  • George Cioroianu,
  • Diana Iulia Stanca,
  • Oana Criciotoiu,
  • Viorel Biciusca,
  • Rodica Magdalena Traistaru and
  • Danut Visarion Caimac

17 November 2023

Our purpose is to emphasize the role of botulinum toxin in spasticity therapy and functional recovery in patients following strokes. Our retrospective study compared two groups, namely ischemic and hemorrhagic stroke patients. The study group (BT gro...

  • Case Report
  • Open Access
4 Citations
5,156 Views
13 Pages

Targeted Physical Therapy Combined with Spasticity Management Changes Motor Development Trajectory for a 2-Year-Old with Cerebral Palsy

  • Corri L. Stuyvenberg,
  • Shaaron E. Brown,
  • Ketaki Inamdar,
  • Megan Evans,
  • Lin-ya Hsu,
  • Olivier Rolin,
  • Regina T. Harbourne,
  • Sarah Westcott McCoy,
  • Michele A. Lobo and
  • Stacey C. Dusing
  • + 1 author

27 February 2021

Therapies for children with cerebral palsy (CP) often fail to address essential components of early rehabilitation: intensity, child initiation, and an embodied approach. Sitting Together And Reaching To Play (START-Play) addresses these issues while...

  • Article
  • Open Access
25 Citations
7,338 Views
11 Pages

Botulinum Toxin Injections and Electrical Stimulation for Spastic Paresis Improve Active Hand Function Following Stroke

  • Jong-Min Lee,
  • Jean-Michel Gracies,
  • Si-Bog Park,
  • Kyu Hoon Lee,
  • Ji Yeong Lee and
  • Joon-Ho Shin

25 October 2018

Botulinum toxin type A (BTX-A) injections improve muscle tone and range of motion (ROM) among stroke patients with upper limb spasticity. However, the efficacy of BTX-A injections for improving active function is unclear. We aimed to determine whethe...

  • Study Protocol
  • Open Access
6 Citations
6,006 Views
11 Pages

17 December 2020

Dry needling (DN) is an emerging technique commonly used in neurological and musculoskeletal pain conditions, but there have been no previous studies in patients with multiple sclerosis (pwMS). This trial aims to assess the efficacy of deep DN, compa...

  • Article
  • Open Access
21 Citations
4,819 Views
12 Pages

BoNT-A for Post-Stroke Spasticity: Guidance on Unmet Clinical Needs from a Delphi Panel Approach

  • Alessio Baricich,
  • Theodore Wein,
  • Nicoletta Cinone,
  • Michele Bertoni,
  • Alessandro Picelli,
  • Carmelo Chisari,
  • Franco Molteni and
  • Andrea Santamato

25 March 2021

There is extensive literature supporting the efficacy of botulinum toxin (BoNT-A) for the treatment of post-stroke spasticity, however, there remain gaps in the routine management of patients with post-stroke spasticity. A panel of 21 Italian experts...

  • Article
  • Open Access
1 Citations
2,451 Views
12 Pages

Comparison of Neurodevelopmental Therapy with Standard Therapy for the Treatment of Patients with Spasticity After Stroke

  • Rafał Studnicki,
  • Maciek Krawczyk,
  • Rita Hansdorfer-Korzon,
  • Igor Z. Zubrzycki and
  • Magdalena Wiacek

15 May 2025

Background/Objectives: The objective of this study was to expose the ability of neurophysiotherapeutic management to reduce spasticity through a modified Ashworth Scale. Methods: The sample, consisting of 102 subjects divided into control and study g...

  • Article
  • Open Access
10 Citations
6,333 Views
14 Pages

Canadian Physicians’ Use of Intramuscular Botulinum Toxin Injections for Shoulder Spasticity: A National Cross-Sectional Survey

  • Farris Kassam,
  • Brendan Lim,
  • Sadia Afroz,
  • Ève Boissonnault,
  • Rajiv Reebye,
  • Heather Finlayson and
  • Paul Winston

10 January 2023

Spasticity of the upper extremity can result in severe pain, along with many complications that can impair a patient’s activities of daily living. Failure to treat patients with spasticity of the upper limb can result in a decrease in the range...

  • Article
  • Open Access
13 Citations
4,137 Views
13 Pages

9 February 2023

Extracorporeal shockwave therapy (ESWT) has been suggested as an alternative treatment for reducing spasticity in patients with cerebral palsy (CP). However, the duration of its effect was rarely known. A meta-analysis was performed to investigate th...

  • Communication
  • Open Access
12 Citations
12,893 Views
7 Pages

7 March 2023

Stiff knee gait (SKG) is defined as decreased knee flexion during the swing phase. It is one of the most common gait disorders following stroke. Knee extensor spasticity is commonly accepted as the primary cause. Clinical management has focused on th...

  • Review
  • Open Access
2 Citations
7,293 Views
20 Pages

Mechanisms of Different Motor Neurons in the Occurrence of Spasticity After Spinal Cord Injury: A Narrative Review

  • Han Gong,
  • Ze-Yan Zhang,
  • Zhi-Xuan Duan,
  • Xin-Ao Mao,
  • Yuan-Yuan Wu,
  • Jia-Sheng Rao and
  • Xiao-Xia Du

Spasticity is a common complication after spinal cord injury (SCI) that significantly diminishes quality of life and complicates daily management. As a hallmark of upper motor neuron lesions, spasticity emerges through a complex post-injury process i...

  • Communication
  • Open Access
9 Citations
4,896 Views
15 Pages

Selecting Goals and Target Muscles for Botulinum Toxin A Injection Using the Goal Oriented Facilitated Approach to Spasticity Treatment (GO-FAST) Tool

  • Jorge Jacinto,
  • Alexander Balbert,
  • Djamel Bensmail,
  • Stefano Carda,
  • Nathalie Draulans,
  • Thierry Deltombe,
  • Nicholas Ketchum,
  • Franco Molteni and
  • Rajiv Reebye

29 November 2023

The objective of this article is to introduce the GO-FAST Tool (developed by the Toxnet group) to clinicians working in the field of neurological rehabilitation, specifically post-stroke spasticity management. The concepts utilized in the Tool and de...

  • Article
  • Open Access
1,677 Views
17 Pages

23 July 2025

Background: Aquatic therapy (AT), immersion in hot water, and supported standing are frequently used to manage spasticity, contractures, and joint retractions in children with cerebral palsy (CP). Recently, the use of exoskeletons has been offering a...

  • Opinion
  • Open Access
3,680 Views
9 Pages

Are We Missing Something About the Maximum Dosing of Botulinum Toxin Type A1 in Adult and Pediatric Patients with Spasticity?

  • Alessandro Picelli,
  • Rita Di Censo,
  • Stefano Tamburin,
  • Nicola Smania and
  • Mirko Filippetti

27 November 2024

Botulinum toxin type A1 is a first-line treatment for adult and pediatric spasticity. However, when considering the quantity of 150 kDa neurotoxin protein in relation to patient weight and the maximum recommended dose for treating adult and pediatric...

  • Case Report
  • Open Access
2,262 Views
10 Pages

Background: Spasticity, a hallmark of quadriplegic cerebral palsy (CP), severely impacts mobility and quality of life. While exercise is known to enhance fitness and motor function in individuals with CP, its specific efficacy in reducing upper extre...

  • Article
  • Open Access
2,297 Views
14 Pages

Introduction: Post-stroke spasticity (PSS) significantly impacts the quality of life for stroke survivors. While various treatments exist, options for refractory cases are limited. Ultrasound-guided percutaneous peripheral nerve stimulation (pPNS), c...

  • Communication
  • Open Access
1 Citations
3,240 Views
10 Pages

Lateral Pectoral Nerve Identification through Ultrasound-Guided Methylene Blue Injection during Selective Peripheral Neurectomy for Shoulder Spasticity: Proposal for a New Procedure

  • Paolo Zerbinati,
  • Jonathan Bemporad,
  • Andrea Massimiani,
  • Edoardo Bianchini,
  • Davide Mazzoli,
  • Davide Glorioso,
  • Giuseppe della Vecchia,
  • Antonio De Luca and
  • Paolo De Blasiis

20 January 2024

Internally rotated and adducted shoulder is a common posture in upper limb spasticity. Selective peripheral neurectomy is a useful and viable surgical technique to ameliorate spasticity, and the lateral pectoral nerve (LPN) could be a potential good...

  • Article
  • Open Access
15 Citations
10,367 Views
13 Pages

Influence of Botulinum Toxin Therapy on Postural Control and Lower Limb Intersegmental Coordination in Children with Spastic Cerebral Palsy

  • Marc Degelaen,
  • Ludo De Borre,
  • Eric Kerckhofs,
  • Linda De Meirleir,
  • Ronald Buyl,
  • Guy Cheron and
  • Bernard Dan

11 January 2013

Botulinum toxin injections may significantly improve lower limb kinematics in gait of children with spastic forms of cerebral palsy. Here we aimed to analyze the effect of lower limb botulinum toxin injections on trunk postural control and lower limb...

  • Opinion
  • Open Access
20 Citations
9,375 Views
17 Pages

Ergonomic Recommendations in Ultrasound-Guided Botulinum Neurotoxin Chemodenervation for Spasticity: An International Expert Group Opinion

  • Philippe Lagnau,
  • Alto Lo,
  • Ryan Sandarage,
  • Katharine Alter,
  • Alessandro Picelli,
  • Jorg Wissel,
  • Monica Verduzco-Gutierrez,
  • Areerat Suputtitada,
  • Michael C. Munin and
  • Rajiv Reebye
  • + 3 authors

31 March 2021

Ultrasound (US)-guided botulinum neurotoxin (BoNT) injections are becoming a mainstay in the treatment of muscle spasticity in upper motor neuron syndromes. As a result, there has been a commensurate increase in US-guided BoNT injection for spasticit...

  • Case Report
  • Open Access
4 Citations
4,969 Views
14 Pages

Spasticity is a common issue among children, especially those with bilateral spastic cerebral palsy (CP). Selective dorsal rhizotomy (SDR) is a surgical procedure that is often used to decrease lower limb rigidity, alongside other treatment options s...

  • Article
  • Open Access
8 Citations
5,986 Views
9 Pages

31 May 2021

Background and Objectives: Spasticity is one of the factors that make it more difficult to control posture in stroke patients. Taping has been used to manage muscle stiffness in various musculoskeletal disorders. Recently, it has been used to decreas...

  • Article
  • Open Access
6 Citations
3,964 Views
14 Pages

28 January 2022

Botulinum neurotoxin (BoNT) is commonly used to manage focal spasticity in stroke survivors. This study aimed to a perform comprehensive assessment of the effects of BoNT injection. Twelve stroke subjects with spastic hemiplegia (age: 52.0 ± 1...

  • Article
  • Open Access
13 Citations
4,081 Views
11 Pages

24 July 2021

Transcutaneous spinal stimulation (TSS) and whole-body vibration (WBV) each have a robust ability to activate spinal afferents. Both forms of stimulation have been shown to influence spasticity in persons with spinal cord injury (SCI), and may be via...

  • Review
  • Open Access
2 Citations
2,548 Views
27 Pages

31 May 2025

Ultrasound-guided botulinum toxin type A (BoNT-A) injections play a critical role in the management of upper limb spasticity. This is the second part of ‘The Elias University Hospital Approach: A Visual Guide to Ultrasound-Guided Botulinum Toxi...

  • Review
  • Open Access
43 Citations
15,422 Views
16 Pages

The Efficacy of Cannabis on Multiple Sclerosis-Related Symptoms

  • Fatma Haddad,
  • Ghadeer Dokmak and
  • Rafik Karaman

5 May 2022

Multiple sclerosis (MS) is known as an autoimmune disease that damages the neurons in the central nervous system. MS is characterized by its most common symptoms of spasticity, muscle spasms, neuropathic pain, tremors, bladder dysfunction, dysarthria...

  • Review
  • Open Access
2 Citations
4,833 Views
13 Pages

25 November 2024

Context: Spastic cerebral palsy (SCP) is a condition characterized by muscle stiffness and involuntary movements, which greatly affect movement abilities and overall well-being. Low-level laser therapy (LLLT) has emerged as a treatment option for man...

  • Review
  • Open Access
2 Citations
3,225 Views
22 Pages

13 May 2025

Ultrasound-guided botulinum toxin type A (BoNT-A) injections have become an essential tool in the management of lower limb spasticity. Following our previous work, which focused on upper limb muscles, this third part provides a detailed visual guide...

  • Article
  • Open Access
2,518 Views
10 Pages

The Variable Influence of Orthotic Management on Hip and Pelvic Rotation in Children with Unilateral Neurogenic Equinus Deformity

  • Domenic Grisch,
  • Manuela Stäuble,
  • Sandra Baumgartner,
  • Hubertus J. A. van Hedel,
  • Andreas Meyer-Heim,
  • Thomas Dreher and
  • Britta Krautwurst

6 February 2023

Background: Equinus deformity with or without concomitant drop foot is a common finding in children with unilateral spastic cerebral palsy and spastic hemiplegia of other causes. Hypothetically, these deformities may lead to pelvic retraction and hip...

  • Article
  • Open Access
9 Citations
3,185 Views
13 Pages

Goal-Setting in Multiple Sclerosis-Related Spasticity Treated with Botulinum Toxin: The GASEPTOX Study

  • Ines Baccouche,
  • Djamel Bensmail,
  • Emilie Leblong,
  • Bastien Fraudet,
  • Claire Aymard,
  • Victorine Quintaine,
  • Sandra Pottier,
  • Thibaud Lansaman,
  • Claire Malot and
  • Jonathan Levy
  • + 1 author

24 August 2022

Spasticity is one of the most disabling symptoms in multiple sclerosis (MS). Botulinum toxin injection (BTI) is a first-line treatment for focal spasticity. There is a lack of evidence of a functional improvement following BTI in MS-related spasticit...

  • Article
  • Open Access
12 Citations
6,321 Views
6 Pages

Ultrasonographic Evaluation of Botulinum Toxin Injection Site for the Medial Approach to Tibialis Posterior Muscle in Chronic Stroke Patients with Spastic Equinovarus Foot: An Observational Study

  • Alessandro Picelli,
  • Alessio Baricich,
  • Elena Chemello,
  • Nicola Smania,
  • Carlo Cisari,
  • Marialuisa Gandolfi,
  • Nicoletta Cinone,
  • Maurizio Ranieri and
  • Andrea Santamato

18 November 2017

The tibialis posterior muscle is a frequent target for injection of botulinum toxin during the management of spastic equinovarus foot in adults with post-stroke spasticity. Although it is deep-seated, the needle insertion into the tibialis posterior...

  • Article
  • Open Access
98 Views
10 Pages

High-Frequency Spinal Cord Stimulation for the Treatment of Spasticity: A Preliminary Case Series

  • Alessandro Izzo,
  • Benedetta Burattini,
  • Renata Martinelli,
  • Quintino Giorgio D’Alessandris,
  • Manuela D'Ercole,
  • Maria Filomena Fuggetta and
  • Nicola Montano

22 January 2026

Background: Spasticity is a complex and multifactorial condition resulting from upper motor neuron injury. It manifests through muscle contractions, pain, limited range of motion, and clonus, which significantly impair daily activities and quality of...

  • Review
  • Open Access
19 Citations
11,283 Views
42 Pages

The Role of Botulinum Toxin Type-A in Spasticity: Research Trends from a Bibliometric Analysis

  • Salvatore Facciorusso,
  • Stefania Spina,
  • Alessandro Picelli,
  • Alessio Baricich,
  • Gerard E. Francisco,
  • Franco Molteni,
  • Jörg Wissel and
  • Andrea Santamato

9 April 2024

Botulinum toxin type-A (BoNT-A) has emerged as a key therapeutic agent for the management of spasticity. This paper presents a comprehensive bibliometric and visual analysis of research concerning BoNT-A treatment of spasticity to elucidate current t...

  • Article
  • Open Access
1 Citations
4,412 Views
10 Pages

An Observational Cross-Sectional Study of Gender and Disability as Determinants of Person-Centered Medicine in Botulinum Neurotoxin Treatment of Upper Motoneuron Syndrome

  • Cristina Maria Del Prete,
  • Mattia Giuseppe Viva,
  • Stefania De Trane,
  • Fabrizio Brindisino,
  • Giovanni Barassi,
  • Alessandro Specchia,
  • Angelo Di Iorio and
  • Raffaello Pellegrino

30 March 2022

The motor behaviour of patients with Upper Motor Neuron Syndrome (UMNS) is characterised by spasticity. The first-line treatment for this clinical condition is Botulinum neurotoxin A (BoNTA), but the number and key locations of muscles which need to...

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