The Efficacy of Cannabis on Multiple Sclerosis-Related Symptoms
Abstract
:1. Introduction
1.1. MS-Related Symptoms
1.1.1. Spasticity in MS
1.1.2. MS-Related Pain
1.1.3. MS-Related Tremor and Ataxia
1.1.4. Bladder Dysfunction in MS
1.1.5. MS-Related Sleep Disorders
1.1.6. Health-Related Quality of Life in MS Patients
1.1.7. MS-Related Disability and Disability Progression
2. Cannabinoid Agents for the Treatment of MS
2.1. Nabiximols
2.1.1. Effects of Nabiximols on MS-Related Spasticity
2.1.2. Effect of Nabiximols on MS-Related Pain
2.1.3. Effects of Nabiximols on MS-Related Tremor
2.1.4. Effect of Nabiximols on MS-Related Bladder Function
2.1.5. Effects of Nabiximols on MS-Related Sleep Disturbances
2.1.6. Effects of Nabiximols on MS-Related HRQoL
2.1.7. Effects of Nabiximols on MS-Related Disability and Disability Progression
2.2. Dronabinol
2.2.1. Effects of Dronabinol on MS-Related Spasticity
2.2.2. Effects of Dronabinol on MS-Related Pain
2.2.3. Effects of Dronabinol on MS-Related Tremor
2.2.4. Effects of Dronabinol on MS-Related Bladder Functions
2.2.5. Effects of Dronabinol on MS-Related Sleep Disorders
2.2.6. Effects of Dronabinol on MS-Related HRQoL
2.2.7. Effects of Dronabinol on MS-Related MS Disability and Disability Progression
2.3. Nabilone
2.3.1. Effects of Nabilone on MS-Related Spasticity
2.3.2. Nabilone Effects on MS-Related Pain
2.3.3. Effects of Nabilone on MS-Related Tremor
2.3.4. Effects of Nabilone on MS-Related Bladder Function
2.3.5. Effects of Nabilone on MS-Related Sleep Disorders
2.3.6. Effects of Nabilone on MS-Related HRQol
2.3.7. Effects of Nabilone on MS Disability and Disability Progression
3. Adverse Effects
3.1. Nabiximols
3.2. Oral Cannabinoids and THC
4. Conclusions
Author Contributions
Funding
Conflicts of Interest
Abbreviations
CBD | cannabidiol |
C. Sativa | Cannabis sativa |
GPCRs | G protein-coupled receptors |
HRQoL | Health-related Quality of life |
MS | multiple sclerosis |
NRS | numerical rating scale |
THC | Δ9-tetrahydrocannabinol |
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Cannabinoid Agents | Therapeutic Actions | Adverse Effects |
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Nabiximols |
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Dronabinol |
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Nabilone |
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Haddad, F.; Dokmak, G.; Karaman, R. The Efficacy of Cannabis on Multiple Sclerosis-Related Symptoms. Life 2022, 12, 682. https://doi.org/10.3390/life12050682
Haddad F, Dokmak G, Karaman R. The Efficacy of Cannabis on Multiple Sclerosis-Related Symptoms. Life. 2022; 12(5):682. https://doi.org/10.3390/life12050682
Chicago/Turabian StyleHaddad, Fatma, Ghadeer Dokmak, and Rafik Karaman. 2022. "The Efficacy of Cannabis on Multiple Sclerosis-Related Symptoms" Life 12, no. 5: 682. https://doi.org/10.3390/life12050682