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  • Review
  • Open Access
15 Citations
6,494 Views
13 Pages

Minimally Invasive Spinal Treatment (MIST)—A New Concept in the Treatment of Spinal Diseases: A Narrative Review

  • Ken Ishii,
  • Goichi Watanabe,
  • Takashi Tomita,
  • Takuya Nikaido,
  • Tomohiro Hikata,
  • Akira Shinohara,
  • Masato Nakano,
  • Takanori Saito,
  • Kazuo Nakanishi and
  • Koji Sato
  • + 7 authors

18 August 2022

In the past two decades, minimally invasive spine surgery (MISS) techniques have been developed for spinal surgery. Historically, minimizing invasiveness in decompression surgery was initially reported as a MISS technique. In recent years, MISS techn...

(This article belongs to the Special Issue Minimally Invasive Spinal Treatment (MIST)—a New Concept in the Treatment of Spinal Diseases)
  • Review
  • Open Access
16 Citations
6,949 Views
9 Pages

Novel Surgical Technique for Adolescent Idiopathic Scoliosis: Minimally Invasive Scoliosis Surgery

  • Sung Cheol Park,
  • Sei Wook Son,
  • Jae Hyuk Yang,
  • Dong-Gune Chang,
  • Seung Woo Suh,
  • Yunjin Nam and
  • Hong Jin Kim

2 October 2022

Despite advancements in instruments and surgical techniques for adolescent idiopathic scoliosis (AIS) surgery, conventional open scoliosis surgery (COSS) is usually required to achieve satisfactory deformity correction using various distinct surgical...

(This article belongs to the Section Orthopedics)
  • Article
  • Open Access
5 Citations
2,112 Views
10 Pages

Impact of Treatment Modalities and Fracture Stability on Survival in Thoracolumbar Fractures: A 5-Year Observational Study

  • Reka Viola,
  • Ádám Juhász,
  • Dávid Süvegh,
  • Dániel Sándor Veres,
  • András Gati,
  • Árpád Viola and
  • Mohammad Walid Al-Smadi

31 January 2025

Background/Objectives: Thoracolumbar fractures are a significant health burden, commonly caused by trauma, osteoporosis, or degenerative conditions, and can severely reduce quality of life and survival. These fractures, classified by the AO Spine Cla...

(This article belongs to the Special Issue Neurosurgery and Spine Surgery: From Up-to-Date Practitioners, 2nd Edition)
  • Article
  • Open Access
11 Citations
6,675 Views
9 Pages

Minimally Invasive Spine Stabilization for Pyogenic Spondylodiscitis: A 23-Case Series and Review of Literature

  • Shinichi Ishihara,
  • Haruki Funao,
  • Norihiro Isogai,
  • Masayuki Ishihara,
  • Takanori Saito and
  • Ken Ishii

Background and Objectives: The incidence of pyogenic spondylodiscitis has been increasing due to the aging of the population. Although surgical treatment is performed for refractory pyogenic spondylodiscitis, surgical invasiveness should be considere...

(This article belongs to the Special Issue Minimally Invasive Spinal Treatment (MIST)—a New Concept in the Treatment of Spinal Diseases)
  • Review
  • Open Access
24 Citations
8,123 Views
10 Pages

The History and Development of the Percutaneous Pedicle Screw (PPS) System

  • Ken Ishii,
  • Haruki Funao,
  • Norihiro Isogai,
  • Takanori Saito,
  • Takeshi Arizono,
  • Masahiro Hoshino and
  • Koji Sato

7 August 2022

Minimally invasive transforaminal lumbar interbody fusion (MIS-TLIF) using the SEXTANT® system (Medtronic) featured the first generation of commercially available percutaneous pedicle screw (PPS) system in 2001. The innovative system has since be...

(This article belongs to the Special Issue Minimally Invasive Spinal Treatment (MIST)—a New Concept in the Treatment of Spinal Diseases)
  • Review
  • Open Access
54 Citations
8,938 Views
12 Pages

Computed Tomography-Based Navigation System in Current Spine Surgery: A Narrative Review

  • Nao Otomo,
  • Haruki Funao,
  • Kento Yamanouchi,
  • Norihiro Isogai and
  • Ken Ishii

5 February 2022

The number of spine surgeries using instrumentation has been increasing with recent advances in surgical techniques and spinal implants. Navigation systems have been attracting attention since the 1990s in order to perform spine surgeries safely and...

(This article belongs to the Section Surgery)
  • Article
  • Open Access
7 Citations
3,932 Views
9 Pages

Efficacy of Minimally Invasive Trans-Sacral Canal Plasty between Patients with and without Failed Back Surgery Syndrome

  • Haruki Funao,
  • Kimiaki Yokosuka,
  • Junichi Ukai,
  • Kazuo Nakanishi,
  • Masaaki Paku,
  • Takashi Tomita,
  • Masahiro Hoshino,
  • Takanori Saito,
  • Ken Ishii and
  • Koji Sato

7 February 2022

Background and Objectives: Clinicians are required to manage a growing number of elderly patients with several medical comorbidities, and invasive surgical treatments are sometimes not advisable for these patients. The aim of this study was to evalua...

(This article belongs to the Special Issue Minimally Invasive Spinal Treatment (MIST)—a New Concept in the Treatment of Spinal Diseases)
  • Systematic Review
  • Open Access
21 Citations
6,901 Views
11 Pages

29 March 2022

Background and Objective: The aim of this review was to analyze the existing literature and investigate the outcomes or complications of lateral lumbar interbody fusion (LLIF) combined with indirect decompression for degenerative lumbar spondylolisth...

(This article belongs to the Special Issue Minimally Invasive Spinal Treatment (MIST)—a New Concept in the Treatment of Spinal Diseases)
  • Review
  • Open Access
2 Citations
2,751 Views
16 Pages

Optimizing Single-Position Prone Lateral Lumbar Interbody Fusion with Exoscopic Technology: A Review of Key Innovations

  • Christian Quinones,
  • John Preston Wilson,
  • Deepak Kumbhare,
  • Bharat Guthikonda and
  • Stanley Hoang

10 February 2025

Minimally invasive spine surgery has advanced significantly over the past decade, integrating technologies such as intraoperative navigation, robotics, and artificial intelligence with innovative techniques such as single-position prone lateral trans...

(This article belongs to the Special Issue Latest Developments in Minimally Invasive Spinal Treatment—2nd Edition)
  • Article
  • Open Access
12 Citations
3,612 Views
7 Pages

Augmented Reality-Assisted Percutaneous Pedicle Screw Instrumentation: A Cadaveric Feasibility and Accuracy Study

  • Chih-Chang Chang,
  • Chao-Hung Kuo,
  • Hsuan-Kan Chang,
  • Tsung-Hsi Tu,
  • Li-Yu Fay,
  • Jau-Ching Wu,
  • Henrich Cheng and
  • Wen-Cheng Huang

23 May 2022

Percutaneous pedicle screw instrumentation is the keystone of minimally invasive spine surgery. Percutaneous screw placement demands experience and relies greatly on intra-operative image guidance. This study aims to validate the feasibility and accu...

(This article belongs to the Special Issue Novel Advances in Computer-Assisted Surgery)
  • Article
  • Open Access
1 Citations
1,643 Views
15 Pages

Radiological and Clinical Outcomes After Navigated Tubular Unilateral Laminotomy for Bilateral Decompression (ULBD) for Lumbar Spinal Stenosis Among Patients with Concurrent Degenerative Scoliosis: A Short-Term Retrospective Case Series

  • Mateusz Bielecki,
  • Chibuikem A. Ikwuegbuenyi,
  • Yizhou Xie,
  • Jessica Berger,
  • Catherine Mykolajtchuk,
  • Anne Schlumprecht,
  • Rodolfo Villalobos-Diaz,
  • Noah Willett,
  • Mousa K. Hamad and
  • Roger Härtl
  • + 3 authors

1 February 2026

Background/Objectives: Adult degenerative scoliosis (ADS) is a spinal disease causing pain and reduced mobility, often occurring with degenerative lumbar spinal stenosis (DLSS). While fusion stabilizes the spine, it has drawbacks like loss of motion...

(This article belongs to the Section Neurosurgery and Neuroanatomy)
  • Review
  • Open Access
31 Citations
7,692 Views
21 Pages

Evolution, Current Trends, and Latest Advances of Endoscopic Spine Surgery

  • Sharvari Gunjotikar,
  • Malcolm Pestonji,
  • Masato Tanaka,
  • Tadashi Komatsubara,
  • Shashank J. Ekade,
  • Ahmed Majid Heydar and
  • Huynh Kim Hieu

29 May 2024

Background: The aging of the population in developing and developed countries has led to a significant increase in the health burden of spinal diseases. These elderly patients often have a number of medical comorbidities due to aging. The need for mi...

(This article belongs to the Special Issue Neurosurgery and Spine Surgery: From Up-to-Date Practitioners)
  • Review
  • Open Access
8 Citations
6,340 Views
16 Pages

Less Is More: Evaluating the Benefits of Minimally Invasive Spinal Surgery

  • Ali A. Mohamed,
  • Rakan Alshaibi,
  • Steven Faragalla,
  • Garrett Flynn,
  • Asad Khan,
  • Emma Sargent,
  • Youssef Mohamed,
  • Camberly Moriconi,
  • Cooper Williams and
  • Brandon Lucke-Wold
  • + 3 authors

25 December 2024

This review aims to explore the evolution, techniques, and outcomes of minimally invasive spine surgery (MISS) within the field of neurosurgery. We sought to address the increasing burden of spine degeneration in a rapidly aging population and the ne...

(This article belongs to the Section Medical Research)
  • Article
  • Open Access
17 Citations
4,871 Views
11 Pages

Augmented Reality Surgical Navigation in Minimally Invasive Spine Surgery: A Preclinical Study

  • Xin Huang,
  • Xiaoguang Liu,
  • Bin Zhu,
  • Xiangyu Hou,
  • Bao Hai,
  • Dongfang Yu,
  • Wenhao Zheng,
  • Ranyang Li,
  • Junjun Pan and
  • Haijun Zeng
  • + 2 authors

Background: In minimally invasive spine surgery (MISS), where the surgeon cannot directly see the patient’s internal anatomical structure, the implementation of augmented reality (AR) technology may solve this problem. Methods: We combined AR,...

(This article belongs to the Section Biomedical Engineering and Biomaterials)
  • Perspective
  • Open Access
26 Citations
6,605 Views
9 Pages

Digital Transformation Will Change Medical Education and Rehabilitation in Spine Surgery

  • Tadatsugu Morimoto,
  • Hirohito Hirata,
  • Masaya Ueno,
  • Norio Fukumori,
  • Tatsuya Sakai,
  • Maki Sugimoto,
  • Takaomi Kobayashi,
  • Masatsugu Tsukamoto,
  • Tomohito Yoshihara and
  • Masaaki Mawatari
  • + 3 authors

2 April 2022

The concept of minimally invasive spine therapy (MIST) has been proposed as a treatment strategy to reduce the need for overall patient care, including not only minimally invasive spine surgery (MISS) but also conservative treatment and rehabilitatio...

(This article belongs to the Special Issue Minimally Invasive Spinal Treatment (MIST)—a New Concept in the Treatment of Spinal Diseases)
  • Review
  • Open Access
3 Citations
2,717 Views
16 Pages

Resident Training in Minimally Invasive Spine Surgery: A Scoping Review

  • Michael C. Oblich,
  • James G. Lyman,
  • Rishi Jain,
  • Dillan Prasad,
  • Sharbel Romanos,
  • Nader Dahdaleh,
  • Najib E. El Tecle and
  • Christopher S. Ahuja

28 August 2025

Background/Objectives: Minimally invasive spine surgery (MISS) is complex and requires proficiency with a variety of technological and robotic modalities. Acquiring these skills is a long and involved process, often with a steep learning curve. This...

(This article belongs to the Section Neurosurgery and Neuroanatomy)
  • Review
  • Open Access
15 Citations
8,036 Views
12 Pages

In the evolving landscape of spinal surgery, technological advancements play a pivotal role in enhancing surgical outcomes and patient experiences. This paper delves into the cutting-edge technologies underpinning endoscopic spine surgery (ESS), spec...

(This article belongs to the Section Regenerative Engineering)
  • Article
  • Open Access
1,300 Views
12 Pages

Reaches of Unilateral Biportal Endoscopy in Lower Thoracic and Lumbar Spinal Extramedullary Tumor Resection: Case Series, Surgical Note, and Outcomes

  • Adrian Sanchez-Gomez,
  • Carlos Castillo-Rangel,
  • Gustavo Alberto Vera-Perez,
  • Malcom D. Prestonji,
  • Rodolfo Guerrero-Perez and
  • Gerardo Marín

21 January 2026

Background: Extramedullary spinal tumors represent a significant challenge for spine surgeons. Currently, various techniques exist to perform tumor resection safely while optimizing patient outcomes. Historically, the standard of care has been open s...

  • Review
  • Open Access
7 Citations
3,904 Views
12 Pages

Minimally Invasive Surgery for Posterior Spinal Instrumentation and Fusion in Adolescent Idiopathic Scoliosis: Current Status and Future Application

  • Ludmilla Bazin,
  • Alexandre Ansorge,
  • Tanguy Vendeuvre,
  • Blaise Cochard,
  • Anne Tabard-Fougère,
  • Oscar Vazquez,
  • Giacomo De Marco,
  • Vishal Sarwahi and
  • Romain Dayer

30 November 2023

The posterior minimally invasive spine surgery (MISS) approach—or the paraspinal muscle approach—for posterior spinal fusion and segmental instrumentation in adolescent idiopathic scoliosis (AIS) was first reported in 2011. It is less inv...

(This article belongs to the Special Issue Advances in Paediatric Spine Surgery)
  • Article
  • Open Access
11 Citations
3,743 Views
11 Pages

9 January 2023

Minimization of the surgical approaches to spinal extradural metastases resection and stabilization was advocated by the 2012 Oncological Guidelines for Spinal Metastases Management. Minimally invasive approaches to spine oncology surgery (MISS) are...

(This article belongs to the Special Issue Spine Surgery – from Basics to Advances Technology)
  • Article
  • Open Access
11 Citations
3,789 Views
11 Pages

Microendoscopic Posterior Decompression for Treating Thoracic Myelopathy Caused by Ossification of the Ligamentum Flavum: Case Series

  • Satoshi Baba,
  • Ryutaro Shiboi,
  • Jyunichi Yokosuka,
  • Yasushi Oshima,
  • Yuichi Takano,
  • Hiroki Iwai,
  • Hirohiko Inanami and
  • Hisashi Koga

10 December 2020

Background and Objectives: Ossification of the ligamentum flavum (OLF) is a relatively common cause of thoracic myelopathy. Surgical treatment is recommended for patients with myelopathy. Generally, open posterior decompression, with or without fusio...

(This article belongs to the Special Issue Complex and Minimally Invasive Spine Surgery)
  • Review
  • Open Access
13 Citations
4,343 Views
14 Pages

Management of Spinal Metastasis by Minimally Invasive Surgical Techniques: Surgical Principles and Indications—A Literature Review

  • Mikael Meyer,
  • Kaissar Farah,
  • Toquart Aurélie,
  • Thomas Graillon,
  • Henry Dufour and
  • Stephane Fuentes

8 August 2023

Background: Spinal metastasis is becoming more frequent. This raises the topics of pain and neurological complications, which worsen the functional and survival prognosis of oncological population patients. Surgical treatment must be as complete as p...

(This article belongs to the Special Issue Latest Developments in Minimally Invasive Spinal Treatment)
  • Article
  • Open Access
2 Citations
906 Views
16 Pages

22 February 2026

Background: Minimally invasive spinal stabilization (MISS) is increasingly used in metastatic spine surgery, but comparative evidence vs. open posterior stabilization (OPEN) remains limited. We compared perioperative outcomes, focusing on wound-relat...

(This article belongs to the Section Orthopedics)
  • Article
  • Open Access
4 Citations
3,795 Views
9 Pages

26 December 2023

Background and Objectives: Minimally invasive spine surgery (MISS) under monitored anesthesia care (MAC) has emerged as a treatment modality for spinal radiculopathy. It is essential to secure the airway and guarantee spontaneous respiration without...

(This article belongs to the Special Issue Anesthesia and Analgesia in Surgical Practice)
  • Article
  • Open Access
4 Citations
3,447 Views
11 Pages

Patient Perceptions of Paramedian Minimally Invasive Spine Skin Incisions

  • Kimberly Quiring,
  • Morgan P. Lorio,
  • Jorge Felipe Ramírez León,
  • Paulo Sérgio Teixeira de Carvalho,
  • Rossano Kepler Alvim Fiorelli and
  • Kai-Uwe Lewandrowski

Background: In clinical outcome studies, patient input into the factors that drive higher satisfaction with lumbar minimally invasive spinal surgery (MISS) is rare. The skin incision is often the only visible consequence of surgery that patients can...

  • Systematic Review
  • Open Access
1 Citations
1,718 Views
12 Pages

Complications in Thoracic Minimally Invasive Spine Surgery (2013–2024): A Systematic Review

  • Sean Inzerillo,
  • Chibuikem A. Ikwuegbuenyi,
  • Eesha Gurav,
  • Noah Willett,
  • Mousa Hamad,
  • Ibrahim Hussain,
  • Alan Hernández-Hernández,
  • Galal Elsayed,
  • Osama Kashlan and
  • Roger Härtl

3 January 2026

Background/Objectives: Thoracic minimally invasive spine surgery (MISS) offers reduced tissue trauma and faster recovery compared with open approaches, but its adoption remains limited due to technical complexity and uncertainty regarding complicatio...

(This article belongs to the Special Issue Clinical Advances in Spine Disorders—2nd Edition)
  • Review
  • Open Access
884 Views
12 Pages

Minimally invasive spine surgery (MISS) has progressively transformed the management of spinal disorders by reducing soft-tissue disruption, perioperative morbidity, and recovery time while maintaining clinical outcomes comparable to conventional ope...

  • Article
  • Open Access
1,011 Views
13 Pages

L5–S1 Anatomic Features Relevant to Minimally Invasive Decompression and Fusion: A Cadaveric and Imaging-Based Study

  • Miguel Relvas-Silva,
  • André Rodrigues Pinho,
  • Vitorino Veludo,
  • Daniel Medina-Dias,
  • António Pereira Rodrigues,
  • Hélio Alves,
  • Maria Dulce Madeira and
  • Pedro Alberto Pereira

19 February 2026

Background/Objectives: The L5–S1 segment presents unique characteristics that make surgical access challenging in minimally invasive spine surgery (MISS) procedures. Variability in bony and neural anatomy may restrict transforaminal and extrafo...

(This article belongs to the Special Issue Contemporary Spine Diagnostics and Management)