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26 Results Found

  • Article
  • Open Access
2 Citations
2,055 Views
21 Pages

Multispectral Pulsed Photobiomodulation Enhances Diabetic Wound Healing via Focal Adhesion-Mediated Cell Migration and Extracellular Matrix Remodeling

  • Jihye Choi,
  • Myung Jin Ban,
  • Chan Hee Gil,
  • Sung Sik Hur,
  • Laurensia Danis Anggradita,
  • Min-Kyu Kim,
  • Ji Won Son,
  • Jung Eun Kim and
  • Yongsung Hwang

Chronic diabetic wounds affect 15–20% of patients and are characterized by impaired healing due to disrupted hemostasis, inflammation, proliferation, and extracellular matrix (ECM) remodeling. Low-level light therapy (LLLT) has emerged as a pro...

  • Review
  • Open Access
8 Citations
9,564 Views
12 Pages

The Potential of Visible and Far-Red to Near-Infrared Light in Glaucoma Neuroprotection

  • Loredana Bergandi,
  • Francesca Silvagno,
  • Giulia Grisolia,
  • Antonio Ponzetto,
  • Emilio Rapetti,
  • Mariarosa Astori,
  • Antonio Vercesi and
  • Umberto Lucia

24 June 2021

Alternative treatment strategies are necessary to reduce the severity of glaucoma, a group of eye conditions that progressively damage the optic nerve and impair vision. The aim of this review is to gain insight into potentially exploitable molecular...

  • Article
  • Open Access
6 Citations
5,520 Views
13 Pages

Effect of Near-Infrared Blood Photobiomodulation on Red Blood Cell Damage from the Extracorporeal Circuit during Hemodialysis In Vitro

  • Tomasz Walski,
  • Karolina Grzeszczuk-Kuć,
  • Weronika Berlik,
  • Izabela Synal-Kulczak,
  • Raghvendra Bohara,
  • Jerzy Detyna and
  • Małgorzata Komorowska

The contact of blood with the bioincompatible membranes of the dialyzer, which is part of the extracorporeal circuit during hemodialysis (HD), causes upregulation of various cellular and non-cellular processes, including massive generation and releas...

  • Article
  • Open Access
1 Citations
2,002 Views
20 Pages

Multispectral Pulsed Photobiomodulation Enhances Re-Epithelialization via Keratinocyte Activation in Full-Thickness Skin Wounds

  • Joo Hyun Kim,
  • Delgerzul Baatar,
  • Myung Jin Ban,
  • Ji Won Son,
  • Jihye Choi,
  • Chan Hee Gil,
  • Min-Kyu Kim,
  • Sung Sik Hur,
  • Jung Eun Kim and
  • Yongsung Hwang

10 September 2025

Chronic wound healing is a complex and tightly regulated process requiring coordinated epithelial and stromal regeneration. Photobiomodulation (PBM) using low-level red light-emitting diode (LED) therapy has emerged as a non-invasive approach to enha...

  • Review
  • Open Access
36 Citations
27,804 Views
13 Pages

Effect of Blue Light on Acne Vulgaris: A Systematic Review

  • Mara Lúcia Gonçalves Diogo,
  • Thalita Molinos Campos,
  • Elsa Susana Reis Fonseca,
  • Christiane Pavani,
  • Anna Carolina Ratto Tempestini Horliana,
  • Kristianne Porta Santos Fernandes,
  • Sandra Kalil Bussadori,
  • Francisca Goreth Malheiro Moraes Fantin,
  • Diego Portes Vieira Leite and
  • Lara Jansiski Motta
  • + 2 authors

19 October 2021

Acne is a dermatosis that affects almost 90% of the adolescent population worldwide and its treatment is performed with retinoids, antimicrobials, acids, and topical or systemic antibiotics. Side effects such as skin irritation in addition to microbi...

  • Article
  • Open Access
7 Citations
6,406 Views
15 Pages

The 1064-nm Nd:YAG Photobiomodulation vs. 20% Benzocaine Topical Gel in Inducing Mucosal Anesthetic Effect: A Double-Blind Randomized Clinical Trial

  • Rita El Feghali,
  • Karen Tatarian,
  • Carla Zogheib,
  • Stefano Benedicenti,
  • Claudio Pasquale and
  • Andrea Amaroli

The periapical local anesthetic injection may be associated with fear of needles and pain administration. Dental topical anesthetic agents can help to reduce pain perception; however, adverse events can occur. To investigate the efficacy of 1064-nm p...

  • Article
  • Open Access
97 Citations
8,770 Views
23 Pages

Photobiomodulation (PBM) has been used for bone regenerative purposes in different fields of medicine and dentistry, but contradictory results demand a skeptical look for its potential benefits. This in vitro study compared PBM potentiality by red (6...

  • Article
  • Open Access
16 Citations
7,327 Views
21 Pages

6 November 2020

Although photobiomodulation (PBM) has proven promising to treat wounds, the lack of univocal guidelines and of a thorough understanding of light–tissue interactions hampers its mainstream adoption for wound healing promotion. This study compare...

  • Systematic Review
  • Open Access
9 Citations
6,925 Views
19 Pages

Low-Level Light Therapy in Orthodontic Treatment: A Systematic Review

  • Francesco Inchingolo,
  • Angelo Michele Inchingolo,
  • Giulia Latini,
  • Gaetano Del Vecchio,
  • Irma Trilli,
  • Laura Ferrante,
  • Gianna Dipalma,
  • Andrea Palermo and
  • Alessio Danilo Inchingolo

17 September 2023

This current review aims to provide an overview of the most recent research from the last 10 years on the potential of low-level light therapy (LLLT) in the orthodontic field, particularly focusing on studies about tooth movement, root resorption, pa...

  • Article
  • Open Access
12 Citations
3,247 Views
12 Pages

Artificial Intelligence-Assisted Terahertz Imaging for Rapid and Label-Free Identification of Efficient Light Formula in Laser Therapy

  • Jia Shi,
  • Zekang Guo,
  • Hongli Chen,
  • Zhitao Xiao,
  • Hua Bai,
  • Xiuyan Li,
  • Pingjuan Niu and
  • Jianquan Yao

5 October 2022

Photodynamic therapy (PDT) is considered a promising noninvasive therapeutic strategy in biomedicine, especially by utilizing low-level laser therapy (LLLT) in visible and near-infrared spectra to trigger biological responses. The major challenge of...

  • Article
  • Open Access
14 Citations
7,679 Views
10 Pages

Biophotonic Effects of Low-Level Laser Therapy at Different Wavelengths for Potential Wound Healing

  • Tzu-Sen Yang,
  • Le-Thanh-Hang Nguyen,
  • Yu-Cheng Hsiao,
  • Li-Chern Pan and
  • Cheng-Jen Chang

19 August 2022

Our objective was to assess the effect of low-level laser therapy (LLLT) administered using a diode laser on the growth processes of human fibroblast cells involved in wound healing. Initially, studies were conducted using a diode laser at wavelength...

  • Article
  • Open Access
3,112 Views
9 Pages

Evaluation of the Low-Level Laser Therapy in Pain, Bite Force, and Mouth Opening Following Midfacial Trauma

  • Mateus Diego Pavelski,
  • Maicon Douglas Pavelski,
  • Luana Ferreira Oliveira,
  • Helio Doyle Pereira da Silva,
  • Lucio Frigo and
  • Osvaldo Magro-Filho

9 December 2024

Low-level laser therapy (LLLT) is known for its biostimulant properties, which can reduce inflammation and promote tissue regeneration. The present study is randomized, blinded, and placebo-controlled and aims to investigate the role of LLLT in the p...

  • Article
  • Open Access
4 Citations
39,974 Views
21 Pages

Effects of Red and Infrared Laser Therapy in Patients with Tinnitus: A Double-Blind, Clinical, Randomized Controlled Study Combining Light with Ultrasound, Drugs and Vacuum Therapy

  • Vitor Hugo Panhóca,
  • Antônio Eduardo de Aquino Junior,
  • Viviane Brocca de Souza,
  • Simone Aparecida Ferreira,
  • Lais Tatiane Ferreira,
  • Karina Jullienne de Oliveira Souza,
  • Patricia Eriko Tamae,
  • Marcelo Saito Nogueira and
  • Vanderlei Salvador Bagnato

26 March 2023

Background: tinnitus is a symptom with no specific cause known to date, and there are no associated pharmacogenomics of hearing disorders and no FDA-approved drugs for tinnitus treatment. The effectiveness of drug treatments is not reproducible on id...

  • Review
  • Open Access
11 Citations
25,258 Views
21 Pages

Background/Objectives: Low-level laser therapy (LLLT) has gained traction in sports and exercise medicine as a non-invasive therapeutic for preconditioning the body, exertion recovery, repair and injury rehabilitation. LLLT is hypothesized to modulat...

  • Review
  • Open Access
4 Citations
13,607 Views
13 Pages

Current Applications and Future Perspectives of Photobiomodulation in Ocular Diseases: A Narrative Review

  • Claudia Cannas,
  • Benedetta Pintus,
  • Lina Corgiolu,
  • Enrico Borrelli,
  • Giacomo Boscia,
  • Mario Damiano Toro and
  • Giuseppe Giannaccare

21 March 2024

The present article provides an overview of photobiomodulation (PBM), also known as low-level laser light therapy (LLLT), which has garnered attention in ophthalmology for its potential therapeutic benefits in various ocular diseases. Photobiomodulat...

  • Article
  • Open Access
717 Views
10 Pages

Low-Level Laser Therapy in Maxillofacial Trauma: A Prospective Single-Arm Observational Study

  • Raissa Dias Fares,
  • Jonathan Ribeiro da Silva,
  • Sylvio Luiz Costa De-Moraes,
  • Jose Mauro Granjeiro and
  • Monica Diuana Calasans-Maia

13 November 2025

Background: Surgical management of trauma in the maxillofacial complex can result in iatrogenic nerve injuries, particularly involving the infraorbital, inferior alveolar, and mental nerves. Paresthesia is a common postoperative complication, often a...

  • Article
  • Open Access
3,459 Views
20 Pages

In Vitro Effects of Low-Level Laser Therapy on the Viability and Secretory Activity of Resting Macrophages

  • Aleksandra Matuła,
  • Amelia Lizak,
  • Ewa Stodolak-Zych,
  • Aneta Bac,
  • Joanna Homa,
  • Beata Stenka and
  • Anna Ścisłowska-Czarnecka

Background/Objectives: Low-level laser therapy (LLLT) covers a wide range of parameters in terms of laser properties and dosage, which is important for its effects. It is important to select safe, optimal irradiation conditions to obtain the desired...

  • Feature Paper
  • Article
  • Open Access
13 Citations
17,536 Views
14 Pages

27 December 2021

A new biotechnology based on micro-needling (MND) with low-level light/laser therapy (LLLT) that is used for hair re-growth (HR-G) needs to be standardized. The study aims to report the clinical outcomes resulting from a multicentric, retrospective,...

  • Article
  • Open Access
422 Views
16 Pages

24 November 2025

Influence of surface pretreatment Hydrofluoric acid (HFA), Erbium yttrium scandium gallium garnet (Er, Cr: YSGG) laser (ECL), and Phthalocyanine (Pc) photosensitizer (Ps) activated by Low-level laser therapy (LLLT) via a light-emitting diode (LED) de...

  • Review
  • Open Access
39 Citations
11,534 Views
22 Pages

The Beneficial Role of Photobiomodulation in Neurodegenerative Diseases

  • Ayodeji Abijo,
  • Chun-Yuan Lee,
  • Chien-Ying Huang,
  • Pei-Chuan Ho and
  • Kuen-Jer Tsai

Photobiomodulation (PBM), also known as Low-level Laser Therapy (LLLT), involves the use of light from a laser or light-emitting diode (LED) in the treatment of various disorders and it has recently gained increasing interest. Progressive neuronal lo...

  • Article
  • Open Access
28 Citations
3,958 Views
15 Pages

23 August 2020

This study aimed at evaluating the visible light mediated antimicrobial and osteogenic applications of noble metal, such as gold (Au) and platinum (Pt) coated titania (TiO2) nanotubes (NTs). In this study, the Au and Pt nanoparticles (NPs) were depos...

  • Systematic Review
  • Open Access
1 Citations
4,193 Views
24 Pages

Photobiomodulation Therapy for Neurosensory Disturbances in Orthognathic Surgery Patients: A Systematic Review

  • Aneta Olszewska,
  • Mateusz Wolny,
  • Julia Kensy,
  • Agnieszka Kotela,
  • Agata Czajka-Jakubowska and
  • Jacek Matys

16 January 2025

Background: Sensory disturbances and acquired paresthesia constitute a significant proportion of complications following orthognathic surgery. This systematic review examines the application of photobiomodulation (PBM) in managing these complications...

  • Systematic Review
  • Open Access
5,566 Views
12 Pages

Near-Infrared Stimulation in Psychiatry Disorders: A Systematic Review of Efficacy and Biological Mechanisms

  • Joanna Woźniak,
  • Michał Pazdrak,
  • Ada Domanasiewicz and
  • Jakub Kaźmierski

Background: Photobiomodulation (PBM), also referred to as low-level light therapy (LLLT), is an emerging non-pharmacological approach. This treatment is considered low-risk, cost-effective, and non-invasive, utilizing near-infrared light (NIR). The p...

  • Article
  • Open Access
41 Citations
8,417 Views
20 Pages

Transcranial near-infrared stimulation (tNIRS) has been proposed as a tool to modulate cortical excitability. However, the underlying mechanisms are not clear where the heating effects on the brain tissue needs investigation due to increased near-inf...

  • Review
  • Open Access
39 Citations
6,273 Views
24 Pages

Application of Fibrin Associated with Photobiomodulation as a Promising Strategy to Improve Regeneration in Tissue Engineering: A Systematic Review

  • Carlos Henrique Bertoni Reis,
  • Daniela Vieira Buchaim,
  • Adriana de Cássia Ortiz,
  • Simone Ortiz Moura Fideles,
  • Jefferson Aparecido Dias,
  • Maria Angelica Miglino,
  • Daniel de Bortoli Teixeira,
  • Eliana de Souza Bastos Mazuqueli Pereira,
  • Marcelo Rodrigues da Cunha and
  • Rogerio Leone Buchaim

2 August 2022

Fibrin, derived from proteins involved in blood clotting (fibrinogen and thrombin), is a biopolymer with different applications in the health area since it has hemostasis, biocompatible and three-dimensional physical structure properties, and can be...

  • Review
  • Open Access
16 Citations
5,513 Views
15 Pages

Photobiomodulation for Chemotherapy-Induced Oral Mucositis in Pediatric Patients

  • Daša Hafner,
  • Petra Hrast,
  • Tanja Tomaževič,
  • Janez Jazbec and
  • Marko Kavčič

23 February 2023

Oral mucositis (OM) is a common side effect in patients undergoing chemotherapy (CT), especially in children due to their rapid epithelial mitotic rate. It has been associated with a significant reduction in life quality since it leads to pain, an in...