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37 Results Found

  • Article
  • Open Access
4 Citations
4,092 Views
13 Pages

Malnutrition–Inflammation Score of Patients with Chronic Kidney Disease from Early Stage to Initiation of Dialysis

  • Lee-Moay Lim,
  • Hung-Tien Kuo,
  • Yu-Lin Chao,
  • Feng-Ching Shen,
  • Yi-Kong Chen,
  • Yi-Wen Chiu,
  • Shang-Jyh Hwang and
  • Chi-Chih Hung

23 November 2024

Background: The malnutrition–inflammation score (MIS) is a practical and accessible tool for evaluating protein energy wasting (PEW) in patients on dialysis. However, the severity of PEW at each stage of chronic kidney disease (CKD), especially...

  • Article
  • Open Access
18 Citations
3,598 Views
12 Pages

Serum Adropin Levels in Patients on Hemodialysis

  • Dijana Boric-Skaro,
  • Maja Mizdrak,
  • Mirko Luketin,
  • Dinko Martinovic,
  • Daria Tokic,
  • Marino Vilovic,
  • Daniela Supe-Domic,
  • Tina Ticinovic Kurir and
  • Josko Bozic

11 April 2021

Adropin is a novel pleotropic peptide involved in energy homeostasis, with possible contribution to cardiovascular protection through production of nitric oxide and subsequent blood pressure regulation. Given that patients undergoing hemodialysis (HD...

  • Article
  • Open Access
15 Citations
3,473 Views
15 Pages

Plasma Catestatin Levels and Advanced Glycation End Products in Patients on Hemodialysis

  • Mirko Luketin,
  • Maja Mizdrak,
  • Dijana Boric-Skaro,
  • Dinko Martinovic,
  • Daria Tokic,
  • Marino Vilovic,
  • Daniela Supe-Domic,
  • Tina Ticinovic Kurir and
  • Josko Bozic

18 March 2021

Catestatin (CST) is a pleiotropic peptide involved in cardiovascular protection with its antihypertensive and angiogenic effects. Considering that patients with end-stage renal disease (ESRD) who are undergoing hemodialysis (HD) are associated with h...

  • Article
  • Open Access
4 Citations
3,757 Views
17 Pages

Nutritional and Hydration Status and Adherence to Dietary Recommendations in Dalmatian Dialysis Patients

  • Ela Kolak,
  • Josipa Radić,
  • Marijana Vučković,
  • Dora Bučan Nenadić,
  • Mirna Begović and
  • Mislav Radić

29 August 2022

Protein-energy wasting (PEW) is considered one of the major complications of chronic kidney disease (CKD), particularly in dialysis patients. Insufficient energy and protein intake, together with clinical complications, may contribute to the onset an...

  • Article
  • Open Access
13 Citations
5,508 Views
11 Pages

Prevalence of Protein-Energy Wasting in Dialysis Patients Using a Practical Online Tool to Compare with Other Nutritional Scores: Results of the Nutrendial Study

  • Marta Arias-Guillén,
  • Silvia Collado,
  • Elisabeth Coll,
  • Jordi Carreras,
  • Loreley Betancourt,
  • Bárbara Romano,
  • Marisol Fernández,
  • Verónica Duarte,
  • Julia Garro and
  • Jordi Calabia
  • + 2 authors

17 August 2022

This cross-sectional study aims to explore the prevalence of protein-energy wasting (PEW) in dialysis patients in Catalonia, Spain, using a new and practical online tool which enables rapid calculation and comparison with other nutritional scores. Me...

  • Concept Paper
  • Open Access
42 Citations
15,334 Views
25 Pages

Intradialytic Nutrition and Hemodialysis Prescriptions: A Personalized Stepwise Approach

  • Giorgina Barbara Piccoli,
  • Francoise Lippi,
  • Antioco Fois,
  • Lurlynis Gendrot,
  • Louise Nielsen,
  • Jerome Vigreux,
  • Antoine Chatrenet,
  • Claudia D’Alessandro,
  • Gianfranca Cabiddu and
  • Adamasco Cupisti

16 March 2020

Dialysis and nutrition are two sides of the same coin—dialysis depurates metabolic waste that is typically produced by food intake. Hence, dietetic restrictions are commonly imposed in order to limit potassium and phosphate and avoid fluid ove...

  • Article
  • Open Access
10 Citations
3,544 Views
20 Pages

Adipokines and Myokines as Markers of Malnutrition and Sarcopenia in Patients Receiving Kidney Replacement Therapy: An Observational, Cross-Sectional Study

  • Sylwia Czaja-Stolc,
  • Antoine Chatrenet,
  • Marta Potrykus,
  • Jakub Ruszkowski,
  • Massimo Torreggiani,
  • Monika Lichodziejewska-Niemierko,
  • Alicja Dębska-Ślizień,
  • Giorgina Barbara Piccoli and
  • Sylwia Małgorzewicz

31 July 2024

Chronic kidney disease (CKD) is linked to an elevated risk of malnutrition and sarcopenia, contributing to the intricate network of CKD-related metabolic disorders. Adipokines and myokines are markers and effectors of sarcopenia and nutritional statu...

  • Article
  • Open Access
7 Citations
3,630 Views
9 Pages

Relationship between Vascular Calcification, Protein-Energy Wasting Syndrome, and Sarcopenia in Maintenance Automated Peritoneal Dialysis

  • Gustavo Leal-Alegre,
  • Claudia Lerma,
  • Gabriela Leal-Escobar,
  • Bernardo Moguel-González,
  • Karen Belén Martínez-Vázquez and
  • Karla Berenice Cano-Escobar

7 July 2021

Vascular calcifications affect 80% to 90% of chronic kidney disease patients and are a predictive factor of cardiovascular mortality. Sarcopenia and protein-energy wasting syndrome are also associated with mortality. The aim was to assess the relatio...

  • Feature Paper
  • Article
  • Open Access
22 Citations
5,116 Views
11 Pages

Assessment of the Nutritional Status and Quality of Life in Chronic Kidney Disease and Kidney Transplant Patients: A Comparative Analysis

  • Weronika Pawlaczyk,
  • Lukasz Rogowski,
  • Joanna Kowalska,
  • Małgorzata Stefańska,
  • Tomasz Gołębiowski,
  • Oktawia Mazanowska,
  • Claire Gerall,
  • Magdalena Krajewska,
  • Mariusz Kusztal and
  • Wioletta Dziubek

14 November 2022

Background: Chronic kidney disease (CKD) can significantly influence a patient’s nutritional status, leading to malnutrition. Malnutrition is associated with an increase in morbidity and hospital admissions, as well as a decrease in functional...

  • Article
  • Open Access
4 Citations
3,445 Views
20 Pages

Positron Emission Tomography Can Support the Diagnosis of Dialysis-Related Amyloidosis

  • Giulia Santagati,
  • Emanuela Cataldo,
  • Valeria Columbano,
  • Antoine Chatrenet,
  • Daniele Penna,
  • Ettore Pelosi,
  • Mammar Hachemi,
  • Lurlinys Gendrot,
  • Louise Nielsen and
  • Giorgina Barbara Piccoli
  • + 4 authors

19 September 2019

Background: The improvements in dialysis have not eliminated long-term problems, including dialysis-related amyloidosis (DRA), caused by Beta-2 microglobulin deposition. Several types of scintigraphy have been tested to detect DRA, none entered the c...

  • Article
  • Open Access
3 Citations
2,243 Views
14 Pages

Risk Factors for Long-Term Nutritional Disorders One Year After COVID-19: A Post Hoc Analysis of COVID-19 Recovery Study II

  • Keiichiro Kawabata,
  • Kensuke Nakamura,
  • Naoki Kanda,
  • Muneaki Hemmi,
  • Shinya Suganuma,
  • Yoko Muto,
  • Arisa Iba,
  • Miyuki Hori,
  • Mariko Hosozawa and
  • Hiroyasu Iso

7 December 2024

Background/Objectives: COVID-19 patients develop various clinical symptoms, including malnutrition. However, the risk factors for long-term nutritional disorders remain unclear. Identifying these factors is crucial for preventing nutritional disorder...

  • Article
  • Open Access
1,819 Views
12 Pages

Relationship between Permanent Catheter Patency and Nutrient Score in Patients Aged >75 Years Requiring Renal Replacement Therapy

  • Moo Jun Kim,
  • Yunkyeong Hwang,
  • Jae Wan Jeon,
  • Hae Ri Kim,
  • Suyeon Han,
  • Heewon Park,
  • Eu Jin Lee,
  • Young Rok Ham,
  • Ki Ryang Na and
  • Dae Eun Choi
  • + 1 author

8 March 2024

Background: Malnutrition is common in patients undergoing hemodialysis and is a powerful predictor of morbidity and mortality. This study aimed to investigate the effect of nutritional status on permanent catheter patency in elderly patients aged >...

  • Article
  • Open Access
405 Views
16 Pages

Modality of Dialysis and Gastrointestinal Symptoms: A Cross-Sectional Study in Jordanian Adults

  • Rami Dwairi,
  • Khitam Al-Refu,
  • Basil Aldiabat,
  • Heba Al-Smirat,
  • Nidal Awad Alnawaiseh,
  • Waleed Alhalabi and
  • Yousef M. Al-Saraireh

Background: Gastrointestinal (GI) symptoms are highly prevalent in people receiving dialysis and contribute to malnutrition and poor quality of life. We examined the prevalence and severity of GI symptoms in Jordanian adults with end-stage kidney dis...

  • Article
  • Open Access
9 Citations
2,714 Views
11 Pages

Body Composition Parameters Correlate to Depression Symptom Levels in Patients Treated with Hemodialysis and Peritoneal Dialysis

  • Marijana Vučković,
  • Josipa Radić,
  • Ela Kolak,
  • Dora Bučan Nenadić,
  • Mirna Begović and
  • Mislav Radić

The aim of this study was to investigate the determinants of depression and nutritional status and their associations in patients treated with hemodialysis (HD) and peritoneal dialysis (PD) and the differences according to the type of treatment. Ther...

  • Article
  • Open Access
18 Citations
6,830 Views
12 Pages

Relationship between Nutritional Status and Gastrointestinal Symptoms in Geriatric Patients with End-Stage Renal Disease on Dialysis

  • Dinorah Carrera-Jiménez,
  • Paola Miranda-Alatriste,
  • Ximena Atilano-Carsi,
  • Ricardo Correa-Rotter and
  • Ángeles Espinosa-Cuevas

29 March 2018

Gastrointestinal symptoms (GIS) are common in patients with end-stage renal disease (ESRD) and are associated with nutritional risks resulting from low food intake. Little is known about the relationship between GIS and malnutrition in geriatric pati...

  • Article
  • Open Access
6 Citations
2,852 Views
14 Pages

Association of Handgrip Strength and Nutritional Status in Non-Dialysis-Dependent Chronic Kidney Disease Patients: Results from the KNOW-CKD Study

  • Minsang Kim,
  • Yeong-Won Park,
  • Dha Woon Im,
  • Yujin Jeong,
  • Hyo Jin Noh,
  • Soo Jin Yang,
  • Eunjeong Kang,
  • Hyunjin Ryu,
  • Jayoun Kim and
  • Kook-Hwan Oh
  • + 3 authors

26 July 2024

Handgrip strength (HGS) is suggested as an indirect assessment of nutritional status in chronic kidney disease (CKD) patients, but evidence is limited for non-dialysis-dependent CKD (NDD-CKD) patients. This cross-sectional study included 404 patients...

  • Concept Paper
  • Open Access
27 Citations
7,592 Views
23 Pages

Prescribing Hemodialysis or Hemodiafiltration: When One Size Does Not Fit All the Proposal of a Personalized Approach Based on Comorbidity and Nutritional Status

  • Giorgina Barbara Piccoli,
  • Louise Nielsen,
  • Lurilyn Gendrot,
  • Antioco Fois,
  • Emanuela Cataldo and
  • Gianfranca Cabiddu

8 October 2018

There is no simple way to prescribe hemodialysis. Changes in the dialysis population, improvements in dialysis techniques, and different attitudes towards the initiation of dialysis have influenced treatment goals and, consequently, dialysis prescrip...

  • Article
  • Open Access
92 Citations
11,039 Views
13 Pages

Malnutrition, Inflammation, Atherosclerosis Syndrome (MIA) and Diet Recommendations among End-Stage Renal Disease Patients Treated with Maintenance Hemodialysis

  • Małgorzata Maraj,
  • Beata Kuśnierz-Cabala,
  • Paulina Dumnicka,
  • Agnieszka Gala-Błądzińska,
  • Katarzyna Gawlik,
  • Dorota Pawlica-Gosiewska,
  • Anna Ząbek-Adamska,
  • Małgorzata Mazur-Laskowska,
  • Piotr Ceranowicz and
  • Marek Kuźniewski

11 January 2018

Malnutrition-inflammation-atherosclerosis syndrome is one of the causes of increased mortality in chronic kidney disease (CKD). The aim of the study was to assess the inflammation and nutritional status of patients in end-stage kidney disease treated...

  • Article
  • Open Access
5 Citations
2,361 Views
14 Pages

Early Detection of Inflammation and Malnutrition and Prediction of Acute Events in Hemodialysis Patients through PINI (Prognostic Inflammatory and Nutritional Index)

  • Monica Cordos,
  • Maria-Alexandra Martu,
  • Cristiana-Elena Vlad,
  • Vasilica Toma,
  • Alin Dumitru Ciubotaru,
  • Minerva Codruta Badescu,
  • Ancuta Goriuc and
  • Liliana Foia

Protein-energy wasting and inflammation are major risk factors for complications in hemodialysis patients. As these risk factors are triggered by a pro-inflammatory state, oxidative stress and hemodynamic dysfunction, which overlap in hemodialyzed su...

  • Article
  • Open Access
9 Citations
2,776 Views
12 Pages

Dietary Micronutrient Intake and Its Relationship with the Malnutrition–Inflammation–Frailty Complex in Patients Undergoing Peritoneal Dialysis

  • Gordon Chun-Kau Chan,
  • Jack Kit-Chung Ng,
  • Phyllis Mei-Shan Cheng,
  • Kai-Ming Chow,
  • Cheuk-Chun Szeto and
  • Philip Kam-Tao Li

27 November 2023

Background: The relationship between dietary patterns and the malnutrition–inflammation–frailty complex in patients undergoing peritoneal dialysis (PD) is currently unknown. Our objective was to measure dietary nutrient intake and evaluat...

  • Article
  • Open Access
788 Views
14 Pages

30 October 2025

Background/Objectives: This study aimed to evaluate the interrelationship between depression and nutritional–metabolic status in geriatric patients with chronic kidney disease (CKD), and to identify the contributing clinical and sociodemographi...

  • Article
  • Open Access
5 Citations
2,202 Views
13 Pages

The Humoral Response to SARS-CoV-2 Vaccine in Hemodialysis Patients Is Correlated with Nutritional Status

  • Merav Jacobson-Naftali,
  • Odile Azoulay,
  • Sigal Frishman,
  • Lihi Godny,
  • Boris Zingerman,
  • Benaya Rozen-Zvi and
  • Timna Agur

24 June 2023

Hemodialysis patients are highly susceptible to poor nutritional status. Our objective was to investigate whether poor nutritional status during mRNA-SARS-CoV-2 vaccination is correlated with impaired vaccine responses. This retrospective study was c...

  • Article
  • Open Access
9 Citations
7,056 Views
16 Pages

Assessment of Factors Related to Diminished Appetite in Hemodialysis Patients with a New Adapted and Validated Questionnaire

  • Elihud Salazar-Robles,
  • Abel Lerma,
  • Martín Calderón-Juárez,
  • Armando Ibarra,
  • Héctor Pérez-Grovas,
  • Luis A. Bermúdez-Aceves,
  • Lilian E. Bosques-Brugada and
  • Claudia Lerma

19 April 2021

Appetite loss is a common phenomenon in end-stage renal disease (ESRD) patients undergoing maintenance hemodialysis (HD). We aimed to (i) adapt and validate a Spanish language version of the Council on Nutrition Appetite Questionnaire (CNAQ) and (ii)...

  • Feature Paper
  • Article
  • Open Access
5 Citations
4,165 Views
14 Pages

Cardiovascular and All-Cause Mortality Is Affected by Serum Magnesium and Diet Pattern in a Cohort of Dialysis Patients

  • Ioannis Petrakis,
  • Dimitra Bacharaki,
  • Periklis Kyriazis,
  • Olga Balafa,
  • Evangelia Dounousi,
  • George Tsirpanlis,
  • Marios Theodoridis,
  • Ourania Tsotsorou,
  • Anastasia Markaki and
  • Kostas Stylianou
  • + 5 authors

10 July 2024

Background: Hypomagnesaemia is associated with an increased overall mortality in patients with chronic kidney disease on dialysis (CKD-5D). Mediterranean-style diet (MD), having a high magnesium content, can serve as a form of dietary magnesium suppl...

  • Article
  • Open Access
12 Citations
2,774 Views
14 Pages

Adherence to the Mediterranean Diet Is Associated with a More Favorable Left Ventricular Geometry in Patients with End-Stage Kidney Disease

  • Dimitra Bacharaki,
  • Ioannis Petrakis,
  • Periklis Kyriazis,
  • Anastasia Markaki,
  • Christos Pleros,
  • Georgios Tsirpanlis,
  • Marios Theodoridis,
  • Olga Balafa,
  • Anastasia Georgoulidou and
  • Kostas Stylianou
  • + 1 author

28 September 2022

Introduction. The aim of the study was to examine the impact of adherence to a Mediterranean-style diet (MD) on left ventricular hypertrophy (LVH) and cardiac geometry in chronic kidney disease patients on dialysis (CKD-5D), given the high prevalence...

  • Article
  • Open Access
34 Citations
4,553 Views
12 Pages

Advanced Glycation End Products (AGE) and Soluble Forms of AGE Receptor: Emerging Role as Mortality Risk Factors in CKD

  • Elena Dozio,
  • Simone Vettoretti,
  • Lara Caldiroli,
  • Silvia Nerini-Molteni,
  • Lorenza Tacchini,
  • Federico Ambrogi,
  • Piergiorgio Messa and
  • Massimiliano M. Corsi Romanelli

Advanced glycation end-products (AGE) can promote chronic kidney disease (CKD) progression and CKD-related morbidities. The soluble receptor for AGE (sRAGE) is a potential biomarker of inflammation and oxidative stress. Here, we explored the role of...

  • Article
  • Open Access
12 Citations
3,424 Views
12 Pages

Impact of Controlling a Nutritional Status Score on Wound Healing in Patients with Chronic Limb-Threatening Ischemia after Endovascular Treatment

  • Kaori Mine,
  • Makoto Sugihara,
  • Takafumi Fujita,
  • Yuta Kato,
  • Koki Gondo,
  • Tadaaki Arimura,
  • Yosuke Takamiya,
  • Yuhei Shiga,
  • Takashi Kuwano and
  • Shin-ichiro Miura

22 October 2021

Background: Chronic limb-threatening ischemia (CLTI) is the most advanced stage of peripheral artery disease. Therefore, a multidisciplinary approach is necessary to avoid major amputation in CLTI patients. Malnutrition worsens the condition of CLTI...

  • Article
  • Open Access
3 Citations
2,761 Views
12 Pages

Hemodialysis Serum Stimulates the TXNIP-eNOS-STAT3 Inflammatory Pathway In Vitro

  • Keren Cohen-Hagai,
  • Hadil Kashua,
  • Sydney Benchetrit and
  • Tali Zitman-Gal

Background: Endothelial dysfunction, vascular inflammation and accelerated atherosclerosis have been investigated extensively in patients with chronic kidney disease (CKD). These conditions, as well as protein–energy malnutrition and oxidative...

  • Review
  • Open Access
1 Citations
4,357 Views
23 Pages

Multifaceted Nutritional Disorders in Elderly Patients Undergoing Dialysis

  • Katsuhito Mori,
  • Masafumi Kurajoh,
  • Masaaki Inaba and
  • Masanori Emoto

22 December 2022

Advances in medicine have resulted in increased longevity, which has consequently led to unexpected geriatric syndromes, such as frailty and sarcopenia. Patients with end-stage kidney disease, especially those receiving dialysis treatment, often show...

  • Article
  • Open Access
4 Citations
3,180 Views
9 Pages

Early Post-Transplant Leptin Concentration Changes in Kidney Transplant Recipients

  • Diana Sukackiene,
  • Agne Laucyte-Cibulskiene,
  • Ignas Badaras,
  • Laurynas Rimsevicius,
  • Valdas Banys,
  • Dalius Vitkus and
  • Marius Miglinas

17 August 2021

Background and Objectives: Kidney transplant recipients represent a unique population with metabolic abnormalities, altered nutritional and immune status, as well as an imbalanced regulation of adipocytokine metabolism. Leptin is a hormonally active...

  • Article
  • Open Access
7 Citations
4,733 Views
13 Pages

Protein Energy Wasting in a Cohort of Maintenance Hemodialysis Patients in Dhaka, Bangladesh

  • Tanjina Rahman,
  • Ban-Hock Khor,
  • Sharmela Sahathevan,
  • Deepinder Kaur,
  • Eno Latifi,
  • Mousume Afroz,
  • Esrat Jahan Mitali,
  • Bayan Tashkandi,
  • Nura Afza Salma Begum and
  • Pramod Khosla
  • + 5 authors

1 April 2022

Malnutrition is associated with high rates of mortality among patients with end stage kidney disease (ESKD). There is a paucity of data from Bangladesh, where around 35,000–40,000 people reach ESKD annually. We assessed protein-energy wasting (...

  • Article
  • Open Access
592 Views
16 Pages

Fatigue and Related Sleep Disturbances in Hemodialysis Patients: Prevalence, Associated Factors, and the Influence of Nutritional Status

  • Ana Casaux-Huertas,
  • María Luz Sánchez-Tocino,
  • Marta San Juan-Miguelsanz,
  • Julia Audije-Gil,
  • Neydu Romero-Lugo,
  • Sonia Muñoz-Pilar,
  • Fabiola Da Pena-Vielba,
  • David Hernan-Gascueña,
  • Paula Manso-Del Real and
  • FRAGILDIAL Working Group, Fundación Renal Española
  • + 4 authors

30 December 2025

Post-dialysis fatigue is one of the most frequent and limiting symptoms among patients undergoing hemodialysis (HD), characterized by intense physical exhaustion that may persist beyond the treatment session. Sleep disturbances frequently coexist wit...

  • Article
  • Open Access
6 Citations
2,723 Views
12 Pages

Each patient undergoing maintenance haemodialysis (MHD) has a different response to erythropoiesis-stimulating agents (ESAs). Haemodilution due to fluid overload has been shown to contribute to anaemia. Body mass index (BMI) has been shown to influen...

  • Article
  • Open Access
11 Citations
3,036 Views
16 Pages

26 April 2022

Background: Anemia is the most common finding in patients with end-stage kidney disease undergoing renal replacement therapy. A certain percentage of patients does not respond adequately to erythropoietin (EPO) treatment, not being able to reach desi...

  • Article
  • Open Access
4 Citations
2,611 Views
15 Pages

The Importance of Biochemical Parameters, Immunonutritional Status, and Social Support for Quality of Life in Chronic Hemodialysis Patients

  • Batric Babovic,
  • Natasa Belada Babovic,
  • Filip Tomovic,
  • Snezana Radovanovic,
  • Mladen Debeljevic,
  • Dusan Mustur and
  • Olgica Mihaljevic

24 October 2024

Background and Objectives: Chronic kidney disease (CKD) is a growing public health problem and one of the leading causes of premature death worldwide. The progressive nature of CKD is associated with serious complications that can reduce the quality...

  • Article
  • Open Access
18 Citations
4,215 Views
15 Pages

Spontaneously Low Protein Intake in Elderly CKD Patients: Myth or Reality? Analysis of Baseline Protein Intake in a Large Cohort of Patients with Advanced CKD

  • Massimo Torreggiani,
  • Antioco Fois,
  • Maria Rita Moio,
  • Antoine Chatrenet,
  • Béatrice Mazé,
  • Françoise Lippi,
  • Jerome Vigreux,
  • Coralie Beaumont,
  • Giulia Santagati and
  • Giorgina Barbara Piccoli
  • + 1 author

6 December 2021

The recent guidelines on nutritional management of chronic kidney disease (CKD) advise a reduction in protein intake as early as CKD stage 3, regardless of age, to slow kidney function impairment. However, since elderly patients are usually considere...

  • Systematic Review
  • Open Access
1 Citations
2,670 Views
15 Pages

Non-Severe Hypophosphatemia in Older Patients: A Systematic Review

  • Luca Barbarossa,
  • Martina Zandonà,
  • Maria Luisa Garo,
  • Ribal Bou Mjahed and
  • Patrizia D’Amelio

16 April 2025

Background/Objectives: Phosphorus plays a fundamental role in cellular and extracellular metabolism, contributing to nucleic acid synthesis, enzymatic activity, neurologic function, and skeletal mineralization. Despite its significance, non-severe hy...