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38 Results Found

  • Article
  • Open Access
12 Citations
3,426 Views
13 Pages

Superior Orbicularis Oris Muscle Activity in Children Surgically Treated for Bilateral Complete Cleft Lip and Palate

  • Liliana Szyszka-Sommerfeld,
  • Monika Elżbieta Machoy,
  • Sławomir Wilczyński,
  • Mariusz Lipski and
  • Krzysztof Woźniak

16 April 2021

The aim of this cross-sectional study was to evaluate the electromyographic activity of the superior orbicularis oris muscle both in children surgically treated for bilateral complete cleft lip and palate (BCCLP) as well as in subjects without BCCLP....

  • Case Report
  • Open Access
4 Citations
273 Views
4 Pages

Fracture of the Vomero-Premaxillary Junction in a Repaired Bilateral Cleft Lip and Palate Patient

  • Roger Arthur Zwahlen,
  • Yasas Shri Nalaka Jayaratne,
  • Su Yin Htun and
  • Kurt-Wilhelm Bütow

Although dental trauma is common in bilateral cleft lip and palate (BCLP), patients’ reports on bony fractures of the vomero-premaxillary junction cannot be found. The aim of this report is to illustrate clinical findings and the technique of fractur...

  • Article
  • Open Access
1 Citations
4,083 Views
25 Pages

11 September 2024

Background: Bilateral cleft lip palate is a severe congenital birth defect of the mouth and face. Immunity factors modulate immune response, inflammation, and healing; therefore, they are vital in the assessment of the immunological status of the pat...

  • Article
  • Open Access
5 Citations
3,913 Views
11 Pages

Evaluation of Lip Morphology and Nasolabial Angle in Non-Syndromic Cleft Lip and/Palate and Non-Cleft Individuals

  • Mohammad Khursheed Alam,
  • Ahmed Ali Alfawzan,
  • Fatema Akhter,
  • Haytham Jamil Alswairki and
  • Prabhat Kumar Chaudhari

30 December 2021

Objective: To investigate the variation between the non-syndromic cleft lip and/or palate (NSCLP) and non-cleft (NC) subjects in relation to the lip morphology (LM) and nasolabial angle (NLA). Materials and Methods: Lateral cephalogram (Late. Ceph.)...

  • Article
  • Open Access
2 Citations
2,801 Views
13 Pages

31 October 2020

The primary correction of congenital complete unilateral cleft lip and palate (UCLP) and bilateral cleft lip and palate (BCLP) is challenging due to inherent lack of palatal tissue and small extent of the palatal shelves at birth. The tissue deficien...

  • Article
  • Open Access
5 Citations
2,187 Views
14 Pages

Comparative Evaluation of Temporomandibular Joint Parameters in Unilateral and Bilateral Cleft Lip and Palate Patients Using Cone-Beam CT: Focus on Growing vs. Non-Growing Subjects

  • Ahmed Z. Abdelkarim,
  • Ahmed A. Almeshari,
  • Duygu Celik Ozen,
  • Ayman R. Khalifa,
  • Nader N. Rezallah,
  • Suayip Burak Duman and
  • Sonam Khurana

7 August 2024

Background: Morphological differences in the temporomandibular joint (TMJ) are crucial for the treatment of patients with cleft lip and palate (CLP). This study aims to evaluate and compare the TMJ parameters in patients with unilateral and bilateral...

  • Article
  • Open Access
5 Citations
2,073 Views
16 Pages

2 December 2024

Background/Objectives: Although there has been extensive research on the orofacial morphologic effects of cleft lip and palate (CLP), the effects of CLP on mandibular structures remain largely unknown. The aim of this study was to investigate the tra...

  • Article
  • Open Access
1 Citations
2,110 Views
20 Pages

What We Learned from Performing the Inverse Malek Procedure to Repair Bilateral Cleft Lips and Palates: A Single-Center Retrospective Study

  • Karim Al-Dourobi,
  • Tessa Mermod,
  • Marie-Thérèse Doan,
  • Georges Herzog,
  • Martin Broome,
  • Oumama El Ezzi and
  • Anthony de Buys Roessingh

27 March 2024

Background: This study reviews the surgical and functional outcomes of children diagnosed with a bilateral cleft lip and palate and treated by the same surgical team following specific surgical protocols 18 years after surgery and during the follow-u...

  • Article
  • Open Access
13 Citations
2,812 Views
26 Pages

Complete Digital Workflow for Manufacturing Presurgical Orthodontic Palatal Plates in Newborns and Infants with Cleft Lip and/or Palate

  • Christina Weismann,
  • Alexander B. Xepapadeas,
  • Marit Bockstedte,
  • Bernd Koos,
  • Michael Krimmel,
  • Christian F. Poets and
  • Maite Aretxabaleta

Deciding on the implementation or modification of steps in daily clinical care is a nuanced process that demands careful evaluation. This is crucial not only for selecting the most appropriate solution but also for achieving the best treatment outcom...

  • Article
  • Open Access
39 Citations
7,720 Views
16 Pages

Nasal deformity is associated with congenital cleft lip and palate. Primary rhinoplasty for reconstruction of the nasal deformity at the time of bilateral cleft lip repair is a controversial issue in cleft care due to traditional teaching concerning...

  • Technical Note
  • Open Access
1 Citations
2,993 Views
17 Pages

Single-Stage Posterior Vomerine Ostectomy, Premaxillary Setback, Bilateral Gingivoperiosteoplasties and Primary Bilateral Cheiloplasty in Patients with Protuberant Premaxilla

  • Usama S. Hamdan,
  • Jose A. Garcia Garcia,
  • Mario S. Haddad,
  • Robert A. Younan,
  • Antonio M. Melhem,
  • Rami S. Kantar and
  • Wassim W. Najjar

29 April 2024

Various patients with complete bilateral cleft lip and palate present with a protruded premaxilla. Several techniques have been described for correctional repair of the projection with a plethora of unsatisfactory outcomes. This poses a challenge not...

  • Article
  • Open Access
5 Citations
4,720 Views
15 Pages

PAX7, PAX9 and RYK Expression in Cleft Affected Tissue

  • Mārtiņš Vaivads,
  • Ilze Akota and
  • Māra Pilmane

8 October 2021

Background and Objectives: Cleft lip with or without cleft palate is one of the most common types of congenital malformations. Transcription factors paired box 7 and 9 (PAX7, PAX9) and receptor-like tyrosine kinase (RYK) have been previously associat...

  • Article
  • Open Access
6 Citations
10,545 Views
14 Pages

Characteristics of Factors Influencing the Occurrence of Cleft Lip and/or Palate: A Case Analysis and Literature Review

  • Małgorzata Kulesa-Mrowiecka,
  • Anna Lipowicz,
  • Bożena Anna Marszałek-Kruk,
  • Damian Kania,
  • Wojciech Wolański,
  • Andrzej Myśliwiec and
  • Krzysztof Dowgierd

28 March 2024

Introduction: Cleft lip with or without cleft palate (CL/P) stands as the most common congenital facial anomaly, stemming from multifactorial causes. Objective: Our study aimed to ascertain the prevalence and characteristics of cleft palates, identif...

  • Article
  • Open Access
4 Citations
2,643 Views
28 Pages

Cleft Lip and Palate Classification Through Vision Transformers and Siamese Neural Networks

  • Oraphan Nantha,
  • Benjaporn Sathanarugsawait and
  • Prasong Praneetpolgrang

25 October 2024

This study introduces a novel approach for the diagnosis of Cleft Lip and/or Palate (CL/P) by integrating Vision Transformers (ViTs) and Siamese Neural Networks. Our study is the first to employ this integration specifically for CL/P classification,...

  • Case Report
  • Open Access
2 Citations
4,369 Views
6 Pages

Prenatal Sonographic and Molecular Genetic Diagnosis of Popliteal Pterygium Syndrome

  • Kuntharee Traisrisilp,
  • Suchaya Luewan,
  • Sirinart Sirilert,
  • Phudit Jatavan and
  • Theera Tongsong

1 October 2021

Popliteal pterygium syndrome (PPS) is an extremely rare autosomal dominant disorder, characterized by the cleft palate with or without cleft lip, limbs abnormalities with highly characteristic features of popliteal webbing, syndactyly, and genital ab...

  • Article
  • Open Access
1 Citations
2,767 Views
18 Pages

3 December 2021

Cleft lips and cleft palates are the most common birth defects in newborns. Pre-surgical correction of unilateral and bilateral cleft lips and palates has been the subject of interest of many previous works. This condition has necessitated the evolut...

  • Article
  • Open Access
2 Citations
3,050 Views
12 Pages

Use of Individually Designed CAD/CAM Suprastructures for Dental Reconstruction in Patients with Cleft Lip and Palate

  • Pilvi Mäntynen,
  • Marisa Laurila,
  • Tommi Strausz,
  • Jari Mauno,
  • Junnu Leikola and
  • Juho Suojanen

11 September 2023

This patient series reports the outcomes of CAD/CAM prosthetic reconstructions in patients with cleft lip and palate (n = 9, aged 27 to 76) who have experienced significant failure with conventional restorative and fixed prosthodontic treatments. The...

  • Feature Paper
  • Article
  • Open Access
9 Citations
3,179 Views
14 Pages

30 May 2023

Cleft lip and palate is the most common asymmetric congenital condition of the orofacial region, which also finds its reflection in dental anomalies. The aim of the study was to present the dental asymmetries of the front region of the maxilla in cle...

  • Article
  • Open Access
1 Citations
5,337 Views
13 Pages

25 April 2025

This paper extends our previous work on cleft lip and/or palate (CL/P) classification, which employed vision transformers (ViTs) and Siamese neural networks. We now integrate SigLIP 2, a state-of-the-art multilingual vision–language model, for...

  • Article
  • Open Access
1,154 Views
17 Pages

The Impact of Integrating 3D-Printed Phantom Heads of Newborns with Cleft Lip and Palate into an Undergraduate Orthodontic Curriculum: A Comparison of Learning Outcomes and Student Perception

  • Sarah Bühling,
  • Jakob Stuhlfelder,
  • Hedi Xandt,
  • Sara Eslami,
  • Lukas Benedikt Seifert,
  • Robert Sader,
  • Stefan Kopp,
  • Nicolas Plein and
  • Babak Sayahpour

16 July 2025

Background/Objectives: This prospective intervention study examined the learning effect of using 3D-printed phantom heads with cleft lip and palate (CLP) and upper jaw models with CLP and maxillary plates during a lecture for dental students in their...

  • Review
  • Open Access
17 Citations
9,129 Views
26 Pages

Orofacial Cleft and Mandibular Prognathism—Human Genetics and Animal Models

  • Anna Jaruga,
  • Jakub Ksiazkiewicz,
  • Krystian Kuzniarz and
  • Przemko Tylzanowski

Many complex molecular interactions are involved in the process of craniofacial development. Consequently, the network is sensitive to genetic mutations that may result in congenital malformations of varying severity. The most common birth anomalies...

  • Article
  • Open Access
6 Citations
4,238 Views
14 Pages

Three-Dimensional Assessment of the Pharyngeal Airway in Growing versus Non-Growing Subjects with/without Cleft Lip and Palate

  • Ahmed Z. Abdelkarim,
  • Ayman R. Khalifa,
  • Mohamed G. Hassan,
  • Ahmed Abdou,
  • Suayip Burak Duman,
  • Nader N. Rezallah,
  • Abdelrahman Elsaid Abdraboh and
  • Ahmed Ghoneima

5 July 2023

Clefts of the lip or palate (CLPs) are the most common craniofacial birth defect, with a worldwide incidence of ~1 in 700 live births. The objective of this study is to assess the characteristics of the nasopharyngeal airway in growing vs. non-growin...

  • Systematic Review
  • Open Access
40 Citations
11,552 Views
17 Pages

Clinical Applications of Artificial Intelligence and Machine Learning in Children with Cleft Lip and Palate—A Systematic Review

  • Mohamed Zahoor Ul Huqh,
  • Johari Yap Abdullah,
  • Ling Shing Wong,
  • Nafij Bin Jamayet,
  • Mohammad Khursheed Alam,
  • Qazi Farah Rashid,
  • Adam Husein,
  • Wan Muhamad Amir W. Ahmad,
  • Sumaiya Zabin Eusufzai and
  • Siddharthan Selvaraj
  • + 5 authors

Objective: The objective of this systematic review was (a) to explore the current clinical applications of AI/ML (Artificial intelligence and Machine learning) techniques in diagnosis and treatment prediction in children with CLP (Cleft lip and palat...

  • Article
  • Open Access
4 Citations
4,195 Views
22 Pages

9 June 2023

Orofacial clefts have been associated with specific cleft candidate genes which encode regulatory proteins required for orofacial region development. Cleft candidate genes encode proteins involved with the cleft morphopathogenesis process, but their...

  • Article
  • Open Access
1 Citations
4,493 Views
11 Pages

Reconstruction of Oronasal Fistula with Tongue Flap: A Cleft Palate Report

  • Francisco Vale,
  • Flávia Pereira,
  • José Saraiva,
  • Eunice Carrilho,
  • Madalena Prata Ribeiro,
  • Filipa Marques,
  • Raquel Travassos,
  • Catarina Nunes,
  • Anabela Baptista Paula and
  • Inês Francisco

Oronasal fistula can persist after conventional secondary alveolar bone graft surgery, which may lead to functional issues, such as regurgitation of fluids from the oral to the nasal cavity. This manuscript describes a clinical case of a patient with...

  • Article
  • Open Access
3 Citations
3,854 Views
10 Pages

Objective: To assess the association between clinical orthodontic indicators and oral-health-related quality of life, adjusted for socio-demographic factors, focusing on 16-year-old patients with cleft lip and/or palate (CL/P). Participants: One hund...

  • Article
  • Open Access
5 Citations
3,287 Views
9 Pages

Frontal and Axial Evaluation of Craniofacial Morphology in Repaired Unilateral Cleft Lip and Palate Patients Utilizing Cone Beam Computed Tomography; An Observational Study

  • Anuraj Singh Kochhar,
  • Maninder Singh Sidhu,
  • Mona Prabhakar,
  • Ritasha Bhasin,
  • Gulsheen Kaur Kochhar,
  • Himanshu Dadlani and
  • Gianrico Spagnuolo

The current study was conducted to assess the extent of maxillary arch collapse on the cleft vis-a-vis non-cleft sides in the same individual presenting withunilateral cleft lip and palate (UCLP), using cone-beam computed tomography (CBCT). Thirty-on...

  • Article
  • Open Access
28 Citations
4,483 Views
11 Pages

Comparative Volume Analysis of Alveolar Defects by 3D Simulation

  • Pang-Yun Chou,
  • Rafael Denadai,
  • Rami R. Hallac,
  • Sarayuth Dumrongwongsiri,
  • Wei-Chuan Hsieh,
  • Betty CJ Pai and
  • Lun-Jou Lo

6 September 2019

A precise volumetric assessment of maxillary alveolar defects in patients with cleft lip and palate can reduce donor site morbidity or allow accurate preparation of bone substitutes in future applications. However, there is a lack of agreement regard...

  • Article
  • Open Access
3 Citations
2,504 Views
10 Pages

17 December 2022

The aim of this cross-sectional study was to examine whether parents/caregivers’ perceptions of oral health-related quality of life (OHRQoL) differ from that of their cleft children, exploring the impact of demographic variables and cleft type on the...

  • Article
  • Open Access
4,708 Views
11 Pages

The Kumagai Method: Feeding Techniques Using the Pigeon Baby Cleft Palate Bottle

  • Shingo Ueki,
  • Yukari Kumagai,
  • Yumi Hirai,
  • Eri Nagatomo,
  • Shoko Miyauchi,
  • Takuro Inoue,
  • Qi An,
  • Eri Tashiro and
  • Junko Miyata

30 September 2024

Background/Objectives: This study aimed to identify the P-bottle feeding techniques systematically organized by Ms. Kumagai, an expert in nursing care for children with a cleft lip and/or palate (CLP), which were developed as she gained expertise in...

  • Article
  • Open Access
5 Citations
2,694 Views
10 Pages

Cutaneous, Cranial, and Skeletal Defects in Children and Adults with Focal Dermal Hypoplasia

  • Ali Al Kaissi,
  • Sergey Ryabykh,
  • Vladimir Kenis,
  • Farid Ben Chehida,
  • Hamza Al Kaissi,
  • Susanne Gerit Kircher and
  • Franz Grill

22 October 2023

Background: The diagnostic process for children and adults manifesting a constellation of ectodermal abnormalities requires a conscientious and highly structured process. Material and Methods: Six girls (aged 6-month–8 years) and two older girl...

  • Case Report
  • Open Access
1 Citations
3,358 Views
13 Pages

Reverse Engineering Orthognathic Surgery and Orthodontics in Individuals with Cleft Lip and/or Palate: A Case Report

  • Jaemin Ko,
  • Mark M. Urata,
  • Jeffrey A. Hammoudeh,
  • Dennis-Duke Yamashita and
  • Stephen L.-K. Yen

This case report presents a virtual treatment simulation of the orthodontic treatment and surgery-first orthognathic surgery employed to treat a patient with a repaired unilateral cleft lip and alveolus with Class III malocclusion and lower third fac...

  • Article
  • Open Access
4 Citations
3,095 Views
12 Pages

18 March 2023

Cleft lip and cleft palate (CLCP) patients often have a retrusive maxilla and a severe skeletal Class III malocclusion, which can result in velopharyngeal insufficiency (VPI). The aim of this study was to evaluate the changes in the volume of the 3D...

  • Article
  • Open Access
4 Citations
2,958 Views
6 Pages

Hearing Status and Ventilation Tube at Time of Palatoplasty in Cleft Lip and Palate Patients: A Retrospective Study

  • Antonio Frisina,
  • Katherine Piacentile,
  • Andrea Frosolini,
  • Roberto Saetti,
  • Ugo Baciliero and
  • Andrea Lovato

6 March 2023

Background and Objectives: There is no consensus regarding the indications for and timing of ventilation tube (VT) insertion in cleft lip and palate (CLP) patients. Our aim was to search for clinical and surgical (i.e., VT insertion) characteristics...

  • Article
  • Open Access
11 Citations
3,118 Views
12 Pages

Progressive Comparison of Density Assessment of Alveolar Bone Graft in Patients with Unilateral and Bilateral Cleft

  • Pin-Ru Chen,
  • Yu-Ching Lin,
  • Betty Chien-Jung Pai,
  • Hsiao-Jung Tseng,
  • Lun-Jou Lo and
  • Pang-Yun Chou

1 November 2021

(1) Background: Continuing to observe the grafted bone mineral density (BMD) is essential to ensure the success of alveolar bone grafting (ABG) in patients with cleft lip and palate. This study elaborates on three methods that can be used to evaluate...

  • Article
  • Open Access
333 Views
12 Pages

Synergistic Triad of Mixed Reality, 3D Printing, and Navigation in Complex Craniomaxillofacial Reconstruction

  • Elijah Zhengyang Cai,
  • Harry Ho Man Ng,
  • Yujia Gao,
  • Kee Yuan Ngiam,
  • Catherine Tong How Lee and
  • Thiam Chye Lim

The craniofacial skeleton is a complex three-dimensional structure, and major reconstructive cases remain challenging. We describe a synergistic approach combining intra-operative navigation, three-dimensionally (3D) printed skull models, and mixed r...

  • Article
  • Open Access
1 Citations
1,147 Views
8 Pages

Radiographic Evaluation of Impacted and Transmigrant Canines: Prevalence and Sex-Based Differences in an Orthodontic Cohort

  • Ioannis P. Zogakis,
  • Chrysanthi Anagnostou,
  • Ioulia Ioannidou,
  • Stella Chaushu and
  • Moschos A. Papadopoulos

26 August 2025

Background/Objectives: Impacted teeth are characterized by having more than three-quarters of root development completed, however failing to erupt or demonstrate imminent eruption, as evidenced both by clinical and radiographic evaluation. Canine imp...

  • Article
  • Open Access
1,022 Views
11 Pages

Objective Evaluation of Nasal Obstruction in Cleft Lip and Palate Patients: A Preliminary Study

  • Nicolas Pachebat,
  • Jiad N. Mcheik,
  • Maxime Fieux,
  • Valentin Favier,
  • Aurélien Binet,
  • Xavier Dufour and
  • Florent Carsuzaa

1 September 2025

Introduction: Cleft lip and/or palate (CLP) is frequently associated with persistent nasal obstruction, often due to structural deformities unaddressed by primary surgical repair. While subjective assessment tools are commonly used to evaluate nasal...