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382 Results Found

  • Article
  • Open Access
2,877 Views
10 Pages

31 July 2021

This article offers a close reading of two sections of Karl Barth’s Church Dogmatics, i.e., §70.1 “The True Witness” and §70.2 “The Falsehood of Man” against the background of the post-truth environment. A brief discussion of the post-truth phenomeno...

  • Feature Paper
  • Article
  • Open Access
5,382 Views
19 Pages

17 October 2022

This article examines Karl Barth’s confrontation with the Nazi past in his post-war occasional writings and speeches from 1945 to 1950. My thesis is that as early as January 1945, months before the end of the war in Europe, Barth publicly argue...

  • Article
  • Open Access
1 Citations
2,993 Views
14 Pages

12 October 2022

This essay considers Karl Barth’s conception of gratitude to God, and the significance of being grateful for one’s own life within his doctrine of creation. I argue that Barth’s account of gratitude authorizes an affirmation of one&...

  • Review
  • Open Access
27 Citations
6,656 Views
28 Pages

Barth Syndrome Cardiomyopathy: An Update

  • Jing Pang,
  • Yutong Bao,
  • Kalia Mitchell-Silbaugh,
  • Jennifer Veevers and
  • Xi Fang

8 April 2022

Barth syndrome (BTHS) is an X-linked mitochondrial lipid disorder caused by mutations in the TAFAZZIN (TAZ) gene, which encodes a mitochondrial acyltransferase/transacylase required for cardiolipin (CL) biosynthesis. Cardiomyopathy is a major clinica...

  • Article
  • Open Access
1,927 Views
13 Pages

6 December 2024

Throughout the twentieth century, U.S. American evangelicals engaged in an ongoing series of definitional debates over the contours and limits of a distinctly evangelical approach to theology. Developed as an explicit counter to theological liberalis...

  • Article
  • Open Access
2,456 Views
20 Pages

15 July 2024

In this article, I explore the significance of the protological and eschatological dimensions of the Trinity, critiquing and building upon the Trinitarian doctrines of Karl Barth and Robert Jenson. The traditional doctrine of the Trinity tends to sep...

  • Article
  • Open Access
2 Citations
4,496 Views
7 Pages

27 September 2017

This study arises from the context of current debates in the Catholic Church on the place of rule and law in moral reasoning. I suggest that ethics may be best served by approaches that place the human subject in a teleogical context and that recogni...

  • Article
  • Open Access
25 Citations
6,613 Views
29 Pages

21 October 2020

Tafazzin is a phospholipid transacylase that catalyzes the remodeling of cardiolipin, a mitochondrial phospholipid required for oxidative phosphorylation. Mutations of the tafazzin gene cause Barth syndrome, which is characterized by mitochondrial dy...

  • Article
  • Open Access
2,006 Views
9 Pages

27 September 2023

In The Christian Life, his unfinished volume of Church Dogmatics, Karl Barth describes sport as “a special form of derangement”. Barth identifies sport as a lordless power, an element of society that humans believe they control, but ends...

  • Article
  • Open Access
2,864 Views
9 Pages

Barth Syndrome: Psychosocial Impact and Quality of Life Assessment

  • Anandbir Bath,
  • Oguz Akbilgic,
  • David Wilbanks,
  • Jay Patel,
  • Morgan Wallen,
  • Shereen Haji,
  • Arnab Das,
  • John Alexander,
  • Issa Pour-Ghaz and
  • Deya Alkhatib
  • + 3 authors

Background: Barth syndrome (BTHS) is a rare X-linked genetic disease that affects multiple systems and leads to complex clinical manifestations. Although a considerable amount of research has focused on the physical aspects of the disease, less has f...

  • Brief Report
  • Open Access
1 Citations
2,242 Views
9 Pages

Cell-Penetrating Peptide Enhances Tafazzin Gene Therapy in Mouse Model of Barth Syndrome

  • Rahul Raghav,
  • Junya Awata,
  • Gregory L. Martin,
  • Douglas Strathdee,
  • Robert M. Blanton and
  • Michael T. Chin

18 December 2024

Barth Syndrome (BTHS) is an early onset, lethal X-linked disorder caused by a mutation in tafazzin (TAFAZZIN), a mitochondrial acyltransferase that remodels monolysocardiolipin (MLCL) to mature cardiolipin (CL) and is essential for normal mitochondri...

  • Article
  • Open Access
4,673 Views
17 Pages

21 March 2022

Adolf Hitler’s rise to power in early 1933 precipitated an ecclesial and theological crisis in the life of the German churches. Karl Barth responded to the crisis in his treatise Theological Existence Today, calling the German church to steadfa...

  • Article
  • Open Access
1,018 Views
11 Pages

4 May 2025

This paper explores the role of biblical exegesis in doctrinal theology. It does so through the lens of Karl Barth’s lectures on New Testament texts given at the University of Göttingen between 1921 and 1925. Contemporary critiques of the...

  • Article
  • Open Access
2,506 Views
15 Pages

14 June 2024

This paper explores Stanley Hauerwas’s unique perspective on the traditions of 20th-century North American theology and ethics, particularly his similarity to Karl Barth in viewing theology and ethics as inseparable. Although deeply influenced...

  • Review
  • Open Access
1 Citations
3,834 Views
30 Pages

18 April 2025

Barth syndrome (BTHS) is inherited through an X-linked pattern. The gene is located on Xq28. Male individuals who inherit the TAFAZZIN pathogenic variant will have the associated condition, while female individuals who inherit the TAFAZZIN pathogenic...

  • Article
  • Open Access
4 Citations
5,351 Views
10 Pages

Phosphokinome Analysis of Barth Syndrome Lymphoblasts Identify Novel Targets in the Pathophysiology of the Disease

  • Prasoon Agarwal,
  • Laura K. Cole,
  • Abin Chandrakumar,
  • Kristin D. Hauff,
  • Amir Ravandi,
  • Vernon W. Dolinsky and
  • Grant M. Hatch

Barth Syndrome (BTHS) is a rare X-linked genetic disease in which the specific biochemical deficit is a reduction in the mitochondrial phospholipid cardiolipin (CL) as a result of a mutation in the CL transacylase tafazzin. We compared the phosphokin...

  • Article
  • Open Access
4 Citations
3,530 Views
13 Pages

Single Cell Transcriptomic Analysis in a Mouse Model of Barth Syndrome Reveals Cell-Specific Alterations in Gene Expression and Intercellular Communication

  • Gayani Perera,
  • Liam Power,
  • Amy Larson,
  • Christina J. Codden,
  • Junya Awata,
  • Rebecca Batorsky,
  • Douglas Strathdee and
  • Michael T. Chin

Barth Syndrome, a rare X-linked disorder affecting 1:300,000 live births, results from defects in Tafazzin, an acyltransferase that remodels cardiolipin and is essential for mitochondrial respiration. Barth Syndrome patients develop cardiomyopathy, m...

  • Article
  • Open Access
592 Views
10 Pages

26 February 2025

This essay responds to Paul Molnar’s Torrance-inspired critique that Barth inappropriately read back elements of subordination into the immanent trinity, improperly introducing a notion of hierarchy within God’s life. It proposes that Nic...

  • Article
  • Open Access
20 Citations
6,357 Views
22 Pages

Barth Syndrome: Exploring Cardiac Metabolism with Induced Pluripotent Stem Cell-Derived Cardiomyocytes

  • Erica M. Fatica,
  • Gina A. DeLeonibus,
  • Alisha House,
  • Jillian V. Kodger,
  • Ryan W. Pearce,
  • Rohan R. Shah,
  • Liraz Levi and
  • Yana Sandlers

17 December 2019

Barth syndrome (BTHS) is an X-linked recessive multisystem disorder caused by mutations in the TAZ gene (TAZ, G 4.5, OMIM 300394) that encodes for the acyltransferase tafazzin. This protein is highly expressed in the heart and plays a significant rol...

  • Article
  • Open Access
5 Citations
2,967 Views
26 Pages

A Barth Syndrome Patient-Derived D75H Point Mutation in TAFAZZIN Drives Progressive Cardiomyopathy in Mice

  • Paige L. Snider,
  • Elizabeth A. Sierra Potchanant,
  • Zejin Sun,
  • Donna M. Edwards,
  • Ka-Kui Chan,
  • Catalina Matias,
  • Junya Awata,
  • Aditya Sheth,
  • P. Melanie Pride and
  • R. Mark Payne
  • + 5 authors

Cardiomyopathy is the predominant defect in Barth syndrome (BTHS) and is caused by a mutation of the X-linked Tafazzin (TAZ) gene, which encodes an enzyme responsible for remodeling mitochondrial cardiolipin. Despite the known importance of mitochond...

  • Article
  • Open Access
15 Citations
4,985 Views
12 Pages

Increased mtDNA Abundance and Improved Function in Human Barth Syndrome Patient Fibroblasts Following AAV-TAZ Gene Delivery

  • Silveli Suzuki-Hatano,
  • Mughil Sriramvenugopal,
  • Manash Ramanathan,
  • Meghan Soustek,
  • Barry J. Byrne,
  • W. Todd Cade,
  • Peter B. Kang and
  • Christina A. Pacak

Barth syndrome (BTHS) is a rare, X-linked, mitochondrial disorder caused by mutations in the gene encoding tafazzin. BTHS results in cardiomyopathy, muscle fatigue, and neutropenia in patients. Tafazzin is responsible for remodeling cardiolipin, a ke...

  • Brief Report
  • Open Access
2,052 Views
9 Pages

16 May 2023

Barth Syndrome (BTHS) is a rare X-linked genetic disease caused by a mutation in the TAFAZZIN gene, which codes for the protein tafazzin involved in cardiolipin remodeling. Approximately 70% of patients with BTHS exhibit severe infections due to neut...

  • Article
  • Open Access
4,166 Views
12 Pages

The Mythologist as a Virologist: Barthes’ Myths as Viruses

  • Thaer T. Al-Kadi and
  • Abdulaziz Ahmad Alzoubi

This article is an attempt to explore and explain the complex processes and mechanisms involved in creating myth signs as presented in Roland Barthes’ Mythologies (1957) through an interdisciplinary and an interdiscursive approach. The article...

  • Commentary
  • Open Access
2 Citations
3,839 Views
7 Pages

28 October 2019

Reverend Dr. James Hal Cone has unquestionably been a key architect in defining Black liberation theology. Trained in the Western theological tradition at Garrett Theological Seminary, Cone became an expert on the theology of Twentieth-century Swiss-...

  • Article
  • Open Access
1 Citations
5,250 Views
17 Pages

5 November 2022

This article discusses the relationship between the divine and the human, as it appears in T.S. Eliot’s play Murder in the Cathedral, written for and performed at the Cathedral of Canterbury in 1935. On the one hand, and most obviously, this pl...

  • Article
  • Open Access
3,077 Views
11 Pages

12 June 2021

This article explores Karl Barth’s exegesis of the ‘sepultus est…’ from the Apostles’ Creed, as articulated in his 1935 Credo lectures. I argue that Barth accords the sepultus a degree of theological significance that is against the grain, not only o...

  • Article
  • Open Access
2,747 Views
15 Pages

18 January 2021

Focusing on the so-called Nördliche Kalkalpen or Northern Limestone Alps of Germany and Austria, I will discuss how human interaction with these mountains during the age of the Anthropocene shifts from scientific and athletic exploration to comm...

  • Article
  • Open Access
2,587 Views
10 Pages

21 July 2023

This essay, which reframes elements of my 2015 book, Daguerreotypes: Fugitive Subjects, Contemporary Objects, returns to the lacuna at the heart of Roland Barthes’s reflections on photo-graphy: the so-called “Winter Garden” photogra...

  • Article
  • Open Access
3 Citations
1 Views
4 Pages

Tafazzin Gene Mutations Are Uncommon Causes of Dilated Cardiomyopathy in Adults

  • Matthew Taylor,
  • Dobromir Slavov,
  • Ernesto Salcedo,
  • Xiao Zhu,
  • Deborah Ferguson,
  • Jean Jirikowic,
  • Andrea Di Lenarda,
  • Gianfranco Sinagra and
  • Luisa Mestroni

Barth syndrome is an X-linked genetic condition featuring neutropenia, skeletal myopathy, and dilated cardiomyopathy in boys due to tafazzin (TAZ) mutations. Pure dilated cardiomyopathy without other features of Barth syndrome may also result from TA...

  • Review
  • Open Access
18 Citations
7,316 Views
15 Pages

Tafazzin, an enzyme associated with the rare inherited x-linked disorder Barth Syndrome, is a nuclear encoded mitochondrial transacylase that is highly conserved across multiple species and plays an important role in mitochondrial function. Numerous...

  • Article
  • Open Access
2 Citations
4,467 Views
22 Pages

3 December 2021

Consideration of the nature of New Testament Theology (NTT) necessitates an account of theology or “God-talk”. Karl Barth grasped that all valid God-talk begins with God’s self-disclosure through Jesus and the Spirit, which people a...

  • Article
  • Open Access
2 Citations
1,999 Views
16 Pages

The Loss of Tafazzin Transacetylase Activity Is Sufficient to Drive Testicular Infertility

  • Paige L. Snider,
  • Elizabeth A. Sierra Potchanant,
  • Catalina Matias,
  • Donna M. Edwards,
  • Jeffrey J. Brault and
  • Simon J. Conway

26 November 2024

Barth syndrome (BTHS) is a rare, infantile-onset, X-linked mitochondriopathy exhibiting a variable presentation of failure to thrive, growth insufficiency, skeletal myopathy, neutropenia, and heart anomalies due to mitochondrial dysfunction secondary...

  • Article
  • Open Access
2 Citations
2,310 Views
23 Pages

Phenotypic Characterization of Female Carrier Mice Heterozygous for Tafazzin Deletion

  • Michelle V. Tomczewski,
  • John Z. Chan,
  • Duaa M. Al-Majmaie,
  • Ming Rong Liu,
  • Alex D. Cocco,
  • Ken D. Stark,
  • Douglas Strathdee and
  • Robin E. Duncan

14 September 2023

Barth syndrome (BTHS) is caused by mutations in tafazzin resulting in deficits in cardiolipin remodeling that alter major metabolic processes. The tafazzin gene is encoded on the X chromosome, and therefore BTHS primarily affects males. Female carrie...

  • Review
  • Open Access
27 Citations
6,730 Views
23 Pages

11 November 2020

The heart is the most energy-consuming organ in the human body. In heart failure, the homeostasis of energy supply and demand is endangered by an increase in cardiomyocyte workload, or by an insufficiency in energy-providing processes. Energy metabol...

  • Article
  • Open Access
6 Citations
3,855 Views
22 Pages

Phenotypic Characterization of Male Tafazzin-Knockout Mice at 3, 6, and 12 Months of Age

  • Michelle V. Tomczewski,
  • John Z. Chan,
  • Zurie E. Campbell,
  • Douglas Strathdee and
  • Robin E. Duncan

Barth syndrome (BTHS) is an X-linked mitochondrial disease caused by mutations in the gene encoding for tafazzin (TAZ), a key enzyme in the remodeling of cardiolipin. Mice with a germline deficiency in Taz have been generated (Taz-KO) but not yet ful...

  • Feature Paper
  • Article
  • Open Access
1 Citations
4,921 Views
14 Pages

11 September 2017

This article presents an annotated English translation of the composer-theologian Dieter Schnebel’s seminal essay exploring music’s spiritual capacities. Speaking explicitly from his time and place, Schnebel considers compositional questions arising...

  • Article
  • Open Access
2,366 Views
10 Pages

12 August 2022

In this essay, I explore how Christians can relate to the Sabbath in a way that adequately expresses Christian traditions about sacred time while showing respect for distinctly Jewish practices. My basic claim is that a Christian sanctification of th...

  • Article
  • Open Access
4,567 Views
12 Pages

30 September 2022

In this essay, we marshal resources from a range of biblical, trinitarian and soteriological commitments, set within a broadly Barthian framework, to offer a doctrinal proposal for the Spirit’s role in the triune God’s work of at-one-ment...

  • Article
  • Open Access
22 Citations
6,019 Views
32 Pages

A Forward-Reverse Brascamp-Lieb Inequality: Entropic Duality and Gaussian Optimality

  • Jingbo Liu,
  • Thomas A. Courtade,
  • Paul W. Cuff and
  • Sergio Verdú

30 May 2018

Inspired by the forward and the reverse channels from the image-size characterization problem in network information theory, we introduce a functional inequality that unifies both the Brascamp-Lieb inequality and Barthe’s inequality, which is a...

  • Article
  • Open Access
9 Citations
5,218 Views
17 Pages

Clostridial C3 Toxins Enter and Intoxicate Human Dendritic Cells

  • Maximilian Fellermann,
  • Christina Huchler,
  • Lea Fechter,
  • Tobias Kolb,
  • Fanny Wondany,
  • Daniel Mayer,
  • Jens Michaelis,
  • Steffen Stenger,
  • Kevin Mellert and
  • Peter Möller
  • + 3 authors

1 September 2020

C3 protein toxins produced by Clostridium (C.) botulinum and C. limosum are mono-ADP-ribosyltransferases, which specifically modify the GTPases Rho A/B/C in the cytosol of monocytic cells, thereby inhibiting Rho-mediated signal transduction in monocy...

  • Review
  • Open Access
83 Citations
16,717 Views
23 Pages

Clostridium perfringens Epsilon Toxin: A Malevolent Molecule for Animals and Man?

  • Bradley G. Stiles,
  • Gillian Barth,
  • Holger Barth and
  • Michel R. Popoff

12 November 2013

Clostridium perfringens is a prolific, toxin-producing anaerobe causing multiple diseases in humans and animals. One of these toxins is epsilon, a 33 kDa protein produced by Clostridium perfringens (types B and D) that induces fatal enteric disease o...

  • Article
  • Open Access
2,273 Views
12 Pages

8 March 2023

This article examines Michael Pinchbeck and Ollie Smith’s theatrical adaptation of A Seventh Man, the 1975 book by John Berger and photographer Jean Mohr studying the experience of migrant workers in Europe. Pinchbeck and Smith’s 2020 ada...

  • Article
  • Open Access
3 Citations
3,784 Views
18 Pages

Phosphatidylglycerol Supplementation Alters Mitochondrial Morphology and Cardiolipin Composition

  • I Chu,
  • Ying-Chih Chen,
  • Ruo-Yun Lai,
  • Jui-Fen Chan,
  • Ya-Hui Lee,
  • Maria Balazova and
  • Yuan-Hao Howard Hsu

The pathogenic variant of the TAZ gene is directly associated with Barth syndrome. Because tafazzin in the mitochondria is responsible for cardiolipin (CL) remodeling, all molecules related to the metabolism of CL can affect or be affected by TAZ mut...

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