Cell-Penetrating Peptide Enhances Tafazzin Gene Therapy in Mouse Model of Barth Syndrome
Abstract
1. Introduction
2. Results and Discussion
3. Materials and Methods
3.1. Generation of Lentiviruses
3.2. Infection of TAFAZZIN KO MEF Cells and Assessment of MLCL/CL Ratio
3.3. Assessment of TAFAZZIN Gene Therapy in TAFAZZIN KO Mice
3.4. Immunohistochemistry of Lentivirally Infected Mouse Hearts
3.5. Assesment of MLCL/CL Ratio in Excised Mouse Heart Mitochondria by Mass Spectrometry
3.6. Statistical Methods
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Raghav, R.; Awata, J.; Martin, G.L.; Strathdee, D.; Blanton, R.M.; Chin, M.T. Cell-Penetrating Peptide Enhances Tafazzin Gene Therapy in Mouse Model of Barth Syndrome. Int. J. Mol. Sci. 2024, 25, 13560. https://doi.org/10.3390/ijms252413560
Raghav R, Awata J, Martin GL, Strathdee D, Blanton RM, Chin MT. Cell-Penetrating Peptide Enhances Tafazzin Gene Therapy in Mouse Model of Barth Syndrome. International Journal of Molecular Sciences. 2024; 25(24):13560. https://doi.org/10.3390/ijms252413560
Chicago/Turabian StyleRaghav, Rahul, Junya Awata, Gregory L. Martin, Douglas Strathdee, Robert M. Blanton, and Michael T. Chin. 2024. "Cell-Penetrating Peptide Enhances Tafazzin Gene Therapy in Mouse Model of Barth Syndrome" International Journal of Molecular Sciences 25, no. 24: 13560. https://doi.org/10.3390/ijms252413560
APA StyleRaghav, R., Awata, J., Martin, G. L., Strathdee, D., Blanton, R. M., & Chin, M. T. (2024). Cell-Penetrating Peptide Enhances Tafazzin Gene Therapy in Mouse Model of Barth Syndrome. International Journal of Molecular Sciences, 25(24), 13560. https://doi.org/10.3390/ijms252413560