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Neurology International, Volume 18, Issue 3

2026 March - 23 articles

Cover Story: Neurodegenerative disorders are characterized by the progressive accumulation of misfolded proteins in the brain. These abnormal protein aggregates disrupt cellular homeostasis, impair synaptic communication, and trigger neuronal dysfunction and death. Over time, their deposition spreads across neural networks, leading to progressive cognitive impairment affecting memory, attention, and executive functions. Conditions including Alzheimer’s disease, Parkinson’s disease, and amyotrophic lateral sclerosis share this common pathological hallmark, although the specific proteins involved may differ. Understanding how protein misfolding and aggregation drive neurodegeneration is critical for identifying novel biomarkers and developing new therapeutic strategies aimed at slowing or preventing cognitive decline. View this paper
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Articles (23)

  • Article
  • Open Access
985 Views
15 Pages

Cognition and Health-Related Quality of Life After aSAH: The Role of Objective and Subjective Impairment

  • Angelka Pešterac-Kujundžić,
  • Una Nedeljković,
  • Ivana Sretenović,
  • Aleksandar Milosavljević,
  • Dragoslav Nestorović,
  • Vojislav Bogosavljević and
  • Ivan Vukašinović

Objectives: Survivors of mild-grade aneurysmal subarachnoid hemorrhage (aSAH) often achieve favorable neurological recovery, yet many continue to experience cognitive difficulties and reduced health-related quality of life (HRQoL). The relative contr...

(This article belongs to the Section Aging Neuroscience)
  • Article
  • Open Access
795 Views
11 Pages

Posterior Communicating Artery Configuration and Laterality of Thalamic and Lenticulostriate Infarction

  • Junpei Nagasawa,
  • Masamichi Hozumi,
  • Tatsuhiro Yokoyama,
  • Makiko Ogawa,
  • Junya Ebina,
  • Mari Shibukawa,
  • Takehisa Hirayama and
  • Osamu Kano

Background: Anatomical variations in the posterior communicating artery (PCoA) are common, but their association with ischemic stroke remains unclear. In this study, we investigated the relationship between PCoA configuration and the localization of...

(This article belongs to the Special Issue Cerebrovascular Disease: Update on Diagnosis and Treatment)
  • Review
  • Open Access
1,562 Views
43 Pages

Duropathies as Unifying Concept—Part Two: A Narrative Overview of Clinical and Neuroradiological Features

  • Marialuisa Zedde,
  • Luigi Cirillo,
  • Elisa Francesca Maria Ciceri,
  • Nicola Limbucci,
  • Mario Muto,
  • Mauro Bergui,
  • Francesco Causin and
  • Rosario Pascarella

Duropathies represent a spectrum of disorders associated with spinal dural tears and cerebrospinal fluid (CSF) leaks. Diagnosis and treatment is often complicated by overlapping clinical manifestations. This review aims to synthesize current literatu...

(This article belongs to the Collection Exclusive Papers from the Editorial Board Members (EBMs) of Neurology International)
  • Review
  • Open Access
1,469 Views
14 Pages

Background: The term dyskinesia describes involuntary movements of the face, body and extremities. Frequently, they appear following and in relation with prior oral long-lasting and high-dose levodopa therapy in Parkinson’s disease patients. On...

(This article belongs to the Collection Exclusive Papers from the Editorial Board Members (EBMs) of Neurology International)
  • Article
  • Open Access
3,459 Views
13 Pages

Delta Power in SLC6A1-Related Neurodevelopmental Disorder: Operationalizing Quantitative EEG Metrics for Biomarker Development

  • Hamza Dahshi,
  • Marie Varnet,
  • Kimberly Goodspeed,
  • Jacob Tiller,
  • Dallas Armstrong and
  • Deepa Sirsi

Introduction: SLC6A1-related neurodevelopmental disorder (SLC6A1-NDD) is an epileptic encephalopathy linked to mutations in the SLC6A1 gene and is characterized by early-onset seizures and developmental delays. Despite the growing recognition of SLC6...

(This article belongs to the Special Issue The Evolving Role of EEG in Neurological Disorders: Advanced Techniques and Future Directions)
  • Case Report
  • Open Access
1,634 Views
10 Pages

Ischemic Stroke as the First Manifestation of Takayasu Arteritis: A Case Report

  • Dominika Jakubowicz-Lachowska,
  • Magdalena Sarnowska,
  • Monika Chorąży and
  • Alina Kułakowska

Introduction: Ischemic stroke in young adults is uncommon and is frequently associated with rare etiologies, including autoimmune diseases and vasculitis. Takayasu arteritis (TA) is a chronic inflammatory large-vessel arteriopathy involving the aorta...

(This article belongs to the Special Issue Cerebrovascular Disease: Update on Diagnosis and Treatment)
  • Article
  • Open Access
1 Citations
1,328 Views
11 Pages

Post-Transplant Tremor: Characteristics and Differences Based on Sex and Post-Transplant Therapy

  • Srdjana Telarovic,
  • Maja Vrdoljak Pazur,
  • Nikolina Zupancic,
  • Anamarija Strajduhar and
  • Irma Telarovic

Background/Objectives: Kidney transplantation is the standard of care for the majority of patients with end-stage kidney disease. Neurological complications are common, and among them, tremor is very frequent and usually attributed to immunosuppressi...

(This article belongs to the Section Movement Disorders and Neurodegenerative Diseases)
  • Systematic Review
  • Open Access
1 Citations
2,194 Views
22 Pages

Effectiveness of Physiotherapy Interventions on Executive Function in Patients with Chronic Pain: A Systematic Review

  • Aser Donado-Bermejo,
  • Silvia Di-Bonaventura,
  • Pablo Barrenechea-Leal,
  • Francisco Mercado-Romero,
  • Marisa Fernández-Sánchez and
  • Raúl Ferrer-Peña

Background: Chronic pain is a prevalent and disabling condition that affects physical health but also cognitive domains. Executive functions, including inhibitory control, cognitive flexibility, and working memory, essentials for self-regulation, tre...

(This article belongs to the Special Issue Non-Invasive Neuromodulation in Treatment of Chronic Pain)
  • Article
  • Open Access
1,280 Views
14 Pages

EEG in the Emergency Department: When the Neurophysiological Test Can Be Avoided in Emergency Diagnostic Workups? The EMINENCE Study

  • Maenia Scarpino,
  • Antonello Grippo,
  • Federica Barraco,
  • Benedetta Piccardi,
  • Laura Betti,
  • Peiman Nazerian,
  • Arianna Fabbri,
  • Roberto Fratangelo,
  • Cristina Mei and
  • Andrea Nencioni

Introduction: This study was conducted to determine whether specific emergency physician (EP) diagnoses and/or neurological signs/symptoms upon admission to the Emergency Department (ED) were associated with normal/non-informative emergency electroen...

  • Review
  • Open Access
5 Citations
1,256 Views
15 Pages

Transthyretin amyloidosis (ATTR) is a progressive multisystem disorder characterized by extracellular deposition of misfolded transthyretin fibrils, leading to neurological, cardiac, gastrointestinal, urogenital, sexual, and ophthalmological involvem...

(This article belongs to the Topic Dysautonomia in Neurological Disorders)
  • Case Report
  • Open Access
1 Citations
1,368 Views
8 Pages

Background: Chronic subdural hematoma is commonly managed with surgical evacuation when significant mass effect or herniation features are present. Although middle meningeal artery embolization has emerged as an effective adjunctive therapy, evidence...

(This article belongs to the Section Brain Tumor and Brain Injury)
  • Article
  • Open Access
746 Views
12 Pages

Neurotrophins Plasma Levels Kinetics in Ischemic Stroke Patients—Potential Relation to Outcomes

  • Radosław Opiła,
  • Karolina Łuczkowska,
  • Edyta Paczkowska,
  • Przemysław Nowacki,
  • Jarosław Peregud-Pogorzelski and
  • Bogusław Machaliński

Background/Objectives: Neurotrophins are a family of structurally related growth factors known to play an important role in the physiology and pathophysiology of the central nervous system. In ischemic stroke, lower blood concentrations of brain-deri...

(This article belongs to the Collection Biomarkers in Stroke Prognosis)
  • Review
  • Open Access
1 Citations
3,143 Views
25 Pages

Genetic Architecture of Cognitive Resilience in Alzheimer’s Disease: Mechanisms, Pathways, and Therapeutic Implications

  • Gabriel Burdman,
  • Juliet Akkaoui,
  • Natalia Colon,
  • Andres Perez and
  • Madepalli K. Lakshmana

Background/Objectives: Alzheimer’s disease (AD) is defined by amyloid-β plaques and tau neurofibrillary tangles and is typically associated with progressive cognitive decline. However, a substantial subset of individuals remains cognitivel...

(This article belongs to the Section Movement Disorders and Neurodegenerative Diseases)
  • Article
  • Open Access
1,285 Views
11 Pages

Sleep-Disordered Breathing in Children with Cerebral Palsy Compared to Non-Neurological Controls: A Prospective Study from a Tertiary Center in Jordan

  • Montaha Al-Iede,
  • Abdallah Al-Ani,
  • Amal Abu Libdeh,
  • Amira Masri,
  • Ahmad T. Qatawneh,
  • Basim Alqutawneh and
  • Nihad A. Almasri

Background/Objectives: Our aim was to evaluate sleep quality and the prevalence of OSA among children with CP and other neurological conditions using both polysomnography (PSG) and validated sleep questionnaires. Methods: This study was conducted at...

  • Review
  • Open Access
5 Citations
2,531 Views
28 Pages

Cognitive decline represents one of the most common clinical manifestations of neurodegenerative diseases (NDs), substantially affecting the quality of life of both patients and their families. Alzheimer’s disease, Parkinson’s disease, an...

(This article belongs to the Section Movement Disorders and Neurodegenerative Diseases)
  • Article
  • Open Access
809 Views
12 Pages

Exploring Trends and Sentiments in Epilepsy Discussions: A Thematic Analysis of the r/Epilepsy Subreddit (2023–2024)

  • Kelly Fisher,
  • Eliza Sejdiu,
  • Michelle You,
  • Rahim Hirani,
  • Adam Karp and
  • Mill Etienne

Background: In 2024, Reddit, an emerging social media platform, saw a 50% increase in monthly users to nearly 100 million. Reddit has also emerged as a significant space for discussions about health conditions, including epilepsy, which affects about...

  • Systematic Review
  • Open Access
1 Citations
1,847 Views
16 Pages

The Driving Profile of Individuals with Schizophrenia: Cognitive Characteristics, Pharmacological Treatment and Driving Competence—A Scoping Review

  • Elpida Stratou,
  • Georgia-Nektaria Porfyri,
  • Aikaterini Gamvroula,
  • Katerina Theodorou,
  • Symeon Dimitrios Daskalou,
  • Nikolaos Gerosideris,
  • Georgia Tsakni,
  • Foteini Christidi,
  • Anna Tsiakiri and
  • Ioanna Giannoula Katsouri
  • + 1 author

Background/Objectives: Driving performance and competence represent a complex functional domain that may be affected in some individuals with schizophrenia. This scoping review aimed to map existing evidence characterizing driving-related functioning...

  • Review
  • Open Access
4 Citations
2,042 Views
25 Pages

Potential Effects of Music on Non-Motor Symptoms in Parkinson’s Disease: Translating Mechanisms to Therapy

  • Christopher G. Ballmann,
  • Daphne G. Schmid,
  • Rebecca R. Rogers,
  • Hannah K. Oakes and
  • Shelby C. Osburn

Non-motor symptoms (NMSs) are highly prevalent in Parkinson’s Disease (PD) and contribute significantly to disease severity, progression, and diminished quality of life. NMSs are rooted in both physiological and psychological domains and includ...

(This article belongs to the Section Movement Disorders and Neurodegenerative Diseases)
  • Brief Report
  • Open Access
5,629 Views
13 Pages

Background: Difficulty swallowing is a common complaint in patients with postural orthostatic tachycardia syndrome (POTS), but there are no qualitative studies that examine dysphagia in patients with POTS, resulting in a significant gap in clinical u...

(This article belongs to the Special Issue Molecular Research of CNS Diseases and Neurological Disorders)
  • Case Report
  • Open Access
1,252 Views
13 Pages

Pilocytic Astrocytoma Causing Brainstem Compression in Pregnancy: Case Report with Literature Review

  • Muratbek A. Tleubergenov,
  • Daniyar K. Zhamoldin,
  • Nurzhan A. Ryskeldiyev,
  • Aigul D. Tolepbergenova,
  • Aisa Z. Nurpeisov,
  • Zhanat T. Takenov and
  • S. Akshulakov

Background: Primary central nervous system tumours in pregnancy are exceptionally rare, with posterior fossa lesions presenting particular diagnostic and management challenges due to their confined anatomical location and proximity to critical neurov...

(This article belongs to the Topic Innovations in Brain Tumor Surgery: Techniques and Outcomes)
  • Article
  • Open Access
1 Citations
1,652 Views
14 Pages

Background/Objectives: Subjective cognitive decline (SCD) is an early stage of dementia, although its risk factors remain unclear. We estimated the prevalence of SCD and its associated dementia risk factors in Brazilian adults. Methods: This cross-se...

(This article belongs to the Section Aging Neuroscience)
  • Article
  • Open Access
1,799 Views
21 Pages

Olfactory and Cognitive Performance Improvement After Oxygen–Ozone Major Autohemotherapy in Mild Cognitive Impairment: A Retrospective Cohort Study

  • Alessandro Micarelli,
  • Simona Mrakic-Sposta,
  • Sandro Malacrida,
  • Alessandra Vezzoli,
  • Riccardo Xavier Micarelli,
  • Beatrice Micarelli,
  • Ivan Granito and
  • Marco Alessandrini

Background/Objectives: Mild cognitive impairment (MCI) is accompanied by olfactory dysfunction, and few interventions target shared chemosensory–cognitive mechanisms. We retrospectively examined whether a 5-week oxygen–ozone major autohem...

(This article belongs to the Section Aging Neuroscience)
  • Systematic Review
  • Open Access
1 Citations
1,798 Views
6 Pages

Metformin Renders Survival Advantage to Patients with Glioblastoma Multiforme

  • Daniel Gonzales-Portillo,
  • Bhavya Vashi,
  • Kirsten Bains Williams and
  • Jorge Cervantes

Purpose: Glioblastoma multiforme (GBM) is a highly aggressive cancer with limited survival despite current treatments. Rising treatment costs highlight the importance of identifying more affordable therapeutic alternatives. A body of literature has s...

(This article belongs to the Section Brain Tumor and Brain Injury)
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Neurol. Int. - ISSN 2035-8377