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Most Cited

  • Review
  • Open Access
122 Citations
21,162 Views
13 Pages

Colorectal Cancer: From Risk Factors to Oncogenesis

  • Vlad Alexandru Ionescu,
  • Gina Gheorghe,
  • Nicolae Bacalbasa,
  • Alexandru Laurentiu Chiotoroiu and
  • Camelia Diaconu

12 September 2023

Colorectal cancer is the second leading cause of cancer-related mortality worldwide. Numerous pathophysiological mechanisms, such as abnormal cell proliferation, cell differentiation, resistance to apoptosis, invasion of structures adjacent to colore...

  • Review
  • Open Access
109 Citations
31,090 Views
20 Pages

Recent Advancement of Medical Patch for Transdermal Drug Delivery

  • Won Fen Wong,
  • Kuan Ping Ang,
  • Gautam Sethi and
  • Chung Yeng Looi

17 April 2023

Transdermal patches are a non-invasive method of drug administration. It is an adhesive patch designed to deliver a specific dose of medication through the skin and into the bloodstream throughout the body. Transdermal drug delivery has several advan...

  • Review
  • Open Access
79 Citations
14,623 Views
15 Pages

Integrating Retrieval-Augmented Generation with Large Language Models in Nephrology: Advancing Practical Applications

  • Jing Miao,
  • Charat Thongprayoon,
  • Supawadee Suppadungsuk,
  • Oscar A. Garcia Valencia and
  • Wisit Cheungpasitporn

8 March 2024

The integration of large language models (LLMs) into healthcare, particularly in nephrology, represents a significant advancement in applying advanced technology to patient care, medical research, and education. These advanced models have progressed...

  • Review
  • Open Access
78 Citations
13,350 Views
46 Pages

13 March 2023

Metabolic syndrome (MetS) is considered a metabolic disorder that has been steadily increasing globally and seems to parallel the increasing prevalence of obesity. It consists of a cluster of risk factors which traditionally includes obesity and hype...

  • Article
  • Open Access
74 Citations
10,571 Views
12 Pages

24 April 2023

Background and Objective: The role of the pharmacist in healthcare society is unique, since they are providers of health information and medication counseling to patients. Hence, this study aimed to evaluate Awareness, Perceptions, and Opinions towar...

  • Article
  • Open Access
68 Citations
5,101 Views
15 Pages

Clinical Trial to Assess Physiology and Activity of Masticatory Muscles of Complete Denture Wearer Following Vitamin D Intervention

  • Shraddha Rathi,
  • Saurabh Chaturvedi,
  • Sabzar Abdullah,
  • Geeta Rajput,
  • Nasser M. Alqahtani,
  • Mudita Chaturvedi,
  • Vishwanath Gurumurthy,
  • Ravinder Saini,
  • Shashit Shetty Bavabeedu and
  • Giuseppe Minervini

20 February 2023

Background and Objectives: Little information is available on the role of Vitamin D as a micro-nutrient deficiency with masticatory muscle efficiency and its effect on the function of removable prosthesis. The aim of this study was to evaluate the ro...

  • Review
  • Open Access
66 Citations
13,310 Views
20 Pages

Ovarian Cancer—Insights into Platinum Resistance and Overcoming It

  • Andrei Havasi,
  • Simona Sorana Cainap,
  • Ana Teodora Havasi and
  • Calin Cainap

10 March 2023

Ovarian cancer is the most lethal gynecologic malignancy. Platinum-based chemotherapy is the backbone of treatment for ovarian cancer, and although the majority of patients initially have a platinum-sensitive disease, through multiple recurrences, th...

  • Article
  • Open Access
56 Citations
13,463 Views
13 Pages

Prevalence and Risk Factors of Metabolic Syndrome: A Prospective Study on Cardiovascular Health

  • Marius Rus,
  • Simina Crisan,
  • Felicia Liana Andronie-Cioara,
  • Mirela Indries,
  • Paula Marian,
  • Oana Lilliana Pobirci and
  • Adriana Ioana Ardelean

25 September 2023

Background and objectives: This article highlights the relationship between metabolic syndrome and cardiovascular disease, providing a comprehensive overview of its risk factors and prevalence. Metabolic syndrome, characterized by a cluster of interc...

  • Review
  • Open Access
52 Citations
13,368 Views
15 Pages

The RANK–RANKL–OPG System: A Multifaceted Regulator of Homeostasis, Immunity, and Cancer

  • Diego De Leon-Oliva,
  • Silvestra Barrena-Blázquez,
  • Laura Jiménez-Álvarez,
  • Oscar Fraile-Martinez,
  • Cielo García-Montero,
  • Laura López-González,
  • Diego Torres-Carranza,
  • Luis M. García-Puente,
  • Sara T. Carranza and
  • Miguel Ángel Álvarez-Mon
  • + 3 authors

30 September 2023

The RANK–RANKL–OPG system is a complex signaling pathway that plays a critical role in bone metabolism, mammary epithelial cell development, immune function, and cancer. RANKL is a ligand that binds to RANK, a receptor expressed on osteoc...

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Medicina - ISSN 1648-9144