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A special issue of Medicina (ISSN 1648-9144). This special issue belongs to the section "Dentistry and Oral Health".

Deadline for manuscript submissions: closed (20 June 2023) | Viewed by 32975

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Prof. Dr. Stefan-Ioan Stratul

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Guest Editor

Department of Periodontology, Faculty of Dental Medicine, Victor Babes University of Medicine and Pharmacy, Timisoara, Romania
Interests: periodontology; dentistry

Dr. Ionut Luchian

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Department of Periodontology, Faculty of Dental Medicine, “Grigore T. Popa” University of Medicine and Pharmacy, 16 Universității Street, 700115 Iași, Romania
Interests: periodontal diseases; periodontology; clinical studies; experimental studies
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Special Issue Information

Dear Colleagues,

Background and history of this topic: Oral diseases have a very high prevalence among humans. At the same time, they are frequently associated with systemic diseases in a bi-directional relationship.

Aim and scope of the Special Issue: This Special Issue aims to update the way in which experimental and clinical study designs contribute to the management of oral diseases, in order to optimize contemporary treatment protocols.

Cutting-edge research: mRNA assay, salivary research, oral histology and immunohistochemistry, molecular biology, cytokines, viruses involved in oral diseases, and clinical studies of oral medicine.

We encourage the submission of original research papers, case reports, systematic reviews, meta-analyses, and narrative reviews.

Prof. Dr. Stefan-Ioan Stratul
Dr. Ionut Luchian
Guest Editors

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Keywords

cytokines
periodontitis
periimplantitis
periodontal disease
salivary markers
crevicular fluid
endodontics
dental caries
SEM
peri-implant diseases
oral medicine
oral lesions

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Research

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11 pages, 1758 KiB

Open AccessArticle

Release of Monomers from Dental Composite Materials into Saliva and the Possibility of Reducing the Toxic Risk for the Patient

by Soňa Tkáčiková and Ján Sabo

Medicina 2023, 59(7), 1204; https://doi.org/10.3390/medicina59071204 - 26 Jun 2023

Cited by 3 | Viewed by 1610

Abstract

Background and Objectives: The objective of this study was (1) to measure the amount of monomers released into the saliva depending on the time elapsed after the hardening of the composite and on the type of monomer used; and (2) with the prolongation of the light-curing procedure, to publish information on whether it would be possible to influence the level of leached monomers. Materials and Methods: HPLC technique was used to monitor the levels of the unpolymerized monomers Bis-GMA, Bis/EMA, TEGDMA, and UDMA from the four commonly used composite materials, released into the saliva of a volunteer with intact dentition. The levels were monitored in 3 time periods during 24 h after composite hardening. From every composite material, 4 samples were formed and cured with an LED lamp for 10 s, 20 s, 40 s, and 60 s. After the light curing, the same polishing procedure was used and the samples were leached in blank saliva samples. Results: We observed that every monitored composite material eluted monomers into the saliva after its application. The amount of monomers depended on the time elapsed after the curing of the composite and on the type of composite used. A 40 s LED curing procedure can reduce the amount of leached monomers in comparison with the standard 20 s procedure, especially for monomers of higher molecular weight. Conclusions: Our study confirmed the hypothesis that the release of monomers gradually decreases with increasing time after the hardening of the composite filling. Full article

(This article belongs to the Special Issue Experimental and Clinical Researches in Oral Medicine)

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15 pages, 3871 KiB

Open AccessArticle

Experimental Study on Mechanical Properties of Different Resins Used in Oral Environments

by Elena-Raluca Baciu, Carmen Nicoleta Savin, Monica Tatarciuc, Ioana Mârțu, Oana Maria Butnaru, Andra Elena Aungurencei, Andrei-Marius Mihalache and Diana Diaconu-Popa

Medicina 2023, 59(6), 1042; https://doi.org/10.3390/medicina59061042 - 28 May 2023

Cited by 3 | Viewed by 2432

Abstract

Background and Objectives: Acrylic resins remain the materials of choice for removable prosthesis due to their indisputable qualities. The continuous evolution in the field of dental materials offers practitioners today a multitude of therapeutic options. With the development of digital technologies, including both subtractive and additive methods, workflow has been considerably reduced and the precision of prosthetic devices has increased. The superiority of prostheses made by digital methods compared to conventional prostheses is much debated in the literature. Our study’s objective was to compare the mechanical and surface properties of three types of resins used in conventional, subtractive, and additive technologies and to determine the optimal material and the most appropriate technology to obtain removable dentures with the highest mechanical longevity over time. Materials and Methods: For the mechanical tests, 90 samples were fabricated using the conventional method (heat curing), CAD/CAM milling, and 3D printing technology. The samples were analyzed for hardness, roughness, and tensile tests, and the data were statistically compared using Stata 16.1 software (StataCorp, College Station, TX, USA). A finite element method was used to show the behavior of the experimental samples in terms of the crack shape and its direction of propagation. For this assessment the materials had to be designed inside simulation software that has similar mechanical properties to those used for obtaining specimens for tensile tests. Results: The results of this study suggested that CAD/CAM milled samples showed superior surface characteristics and mechanical properties, comparable with conventional heat-cured resin samples. The propagation direction predicted by the finite element analysis (FEA) software was similar to that observed in a real-life specimen subjected to a tensile test. Conclusions: Removable dentures made from heat-cured resins remain a clinically acceptable option due to their surface quality, mechanical properties, and affordability. Three-dimensional printing technology can be successfully used as a provisional or emergency therapeutic solution. CAD/CAM milled resins exhibit the best mechanical properties with great surface finishes compared to the other two processing methods. Full article

(This article belongs to the Special Issue Experimental and Clinical Researches in Oral Medicine)

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11 pages, 660 KiB

Open AccessArticle

In Vitro Evaluation of the Accuracy of Three Electronic Apex Locators Using Different Sodium Hypochlorite Concentrations

by Sanda Ileana Cîmpean, Radu Marcel Chisnoiu, Adela Loredana Colceriu Burtea, Rareș Rotaru, Marius Gheorghe Bud, Ada Gabriela Delean and Ioana-Sofia Pop-Ciutrilă

Medicina 2023, 59(5), 918; https://doi.org/10.3390/medicina59050918 - 11 May 2023

Cited by 4 | Viewed by 2513

Abstract

Background and Objectives: The aim of this study was to compare the accuracy of three types of electronic apex locators (EALs) when two different concentrations of NaOCl irrigation solutions are used by two operators. Materials and Methods: After creating the access cavities for 20 single rooted extracted teeth, the actual canal length (ACL) of each canal was determined visually using a #10 file and magnification. The teeth were subsequently inserted in plastic molds filled with alginate. The electronic measurement of root canal length (EWL) was performed using three different electronic apex locators: Root ZX II, Apex ID, and Dual Pex. Two independent operators, an endodontic specialist with 20 years practice and an undergraduate student in the final year of study, performed the irrigation procedures with two different concentrations of NaOCl (2% and 5.25%), and then measured the EWL using each of the EALs. The accuracy of all EALs, was determined in each case by subtracting the EWL from the ACL. Statistical analyses were performed using one-way ANOVA test. Results: In the presence of 2% NaOCl solution, for a margin error of ±0.5 mm, Root ZX II, Apex ID, and Dual Pex presented an accuracy of 90%, 80%, and 85% respectively. The increase in the concentration of the irrigation solution affected the accuracy of Root ZX II and Apex ID for both operators, diminishing it to 75% for the same margin error, but improved Dual Pex’s accuracy to 100%. Conclusions: The best accuracy in working length determination was obtained by Root ZX II for 2% NaOCl solution and by Dual Pex for 5.25% NaOCl solution with no significant statistical difference when compared. Full article

(This article belongs to the Special Issue Experimental and Clinical Researches in Oral Medicine)

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13 pages, 2638 KiB

Open AccessArticle

Effects of Diabetes and Voluntary Exercise on IgA Concentration and Polymeric Immunoglobulin Receptor Expression in the Submandibular Gland of Rats

by Jaebum Park, Yuko Yamamoto, Kouki Hidaka, Satoko Wada-Takahashi, Shun-suke Takahashi, Toshiya Morozumi, Nobuhisa Kubota, Makiko Saita, Juri Saruta, Wakako Sakaguchi, Masahiro To, Tomoko Shimizu, Yuko Mikuni-Takagaki and Keiichi Tsukinoki

Medicina 2023, 59(4), 789; https://doi.org/10.3390/medicina59040789 - 18 Apr 2023

Viewed by 2170

Abstract

Background and Objectives: Patients with diabetes are more susceptible to upper respiratory tract infections (URTIs) because they are easily infected. Salivary IgA (sali-IgA) levels play a major role in transmitting URTIs. Sali-IgA levels are determined by salivary gland IgA production and polymeric immunoglobulin receptor (poly-IgR) expression. However, it is unknown whether salivary gland IgA production and poly-IgR expression are decreased in patients with diabetes. While exercise is reported to increase or decrease the sali-IgA levels, it is unclear how exercise affects the salivary glands of patients with diabetes. This study aimed to determine the effects of diabetes and voluntary exercise on IgA production and poly-IgR expression in the salivary glands of diabetic rats. Materials and Methods: Ten spontaneously diabetic Otsuka Long–Evans Tokushima Fatty (OLETF) rats (eight-week-old) were divided into two groups of five rats each: a non-exercise group (OLETF-C) and a voluntary wheel-running group (OLETF-E). Five Long–Evans Tokushima Otsuka (LETO) rats without diabetes were bred under the same conditions as the OLETF-C. Sixteen weeks after the study began, the submandibular glands (SGs) were collected and analyzed for IgA and poly-IgR expression levels. Results: IgA concentrations and poly-IgR expression levels in SGs were lower in OLETF-C and OLETF-E than in LETO (p < 0.05). These values did not differ between the OLETF-C and OLETF-E. Conclusions: Diabetes decreases IgA production and poly-IgR expression in the salivary glands of rats. Moreover, voluntary exercise increases sali-IgA levels but does not increase IgA production and poly-IgR expression in the salivary glands of diabetic rats. Increasing IgA production and poly-IgR expression in the salivary glands, which is reduced in diabetes, might require slightly higher-intensity exercise than voluntary exercise under the supervision of a doctor. Full article

(This article belongs to the Special Issue Experimental and Clinical Researches in Oral Medicine)

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13 pages, 5997 KiB

Open AccessArticle

Radiographic Evaluation of the Gap between Cemented Post and Remaining Gutta-Percha in Endodontically Treated Teeth Performed by Undergraduate Students: A Retrospective Cross-Sectional Study

by Hina Naim, Manawar Ahmad, Abrar A. Ageeli, Raghad K. Abuarab, Mohammed E. Sayed, Harisha Dewan, Hitesh Chohan, Abdullah Hasan Alshehri, Mohammed Hussain Dafer Al Wadei, Saeed M. Alqahtani, Shaikh Mohammad Abdul Feroz, Amit Porwal and Ahid Amer Alshahrani

Medicina 2023, 59(3), 502; https://doi.org/10.3390/medicina59030502 - 3 Mar 2023

Cited by 5 | Viewed by 4345

Abstract

The coronal seal in root canal-treated teeth may be compromised depending on the accuracy of post space preparation and post cementation along with remaining gutta-percha. Root canal treatment can be compromised by endotoxins released by the coronal bacteria as a result of microleakage. The study was conducted by undergraduate students to measure the gap between the cemented post and residual gutta-percha. In total, 217 endodontically treated teeth were evaluated with intraoral peri-apical radiographs. Based on the intraoral periapical radiographic examination in the CS-R4 program, Group I had no gap, Group II had a gap of >0 to 2 mm, and Group III had a gap of more than 2 mm between the end of the cemented post and the remaining gutta-percha. In total, 40% (n = 87) of the teeth had no gap, 59% (127) had a gap of >0 to 2 mm, and 1% (n = 3) had a gap of more than 2 mm between the cemented post end and remaining gutta. Chi square test revealed a significant difference in the gap between the post and remaining gutta-percha between males and females students (p < 0.001). In terms of the gap between the cemented post end and the residual gutta-percha, the root canal treated teeth with post and core by undergraduates were clinically acceptable. Full article

(This article belongs to the Special Issue Experimental and Clinical Researches in Oral Medicine)

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15 pages, 670 KiB

Open AccessArticle

Clinical Trial to Assess Physiology and Activity of Masticatory Muscles of Complete Denture Wearer Following Vitamin D Intervention

by Shraddha Rathi, Saurabh Chaturvedi, Sabzar Abdullah, Geeta Rajput, Nasser M. Alqahtani, Mudita Chaturvedi, Vishwanath Gurumurthy, Ravinder Saini, Shashit Shetty Bavabeedu and Giuseppe Minervini

Medicina 2023, 59(2), 410; https://doi.org/10.3390/medicina59020410 - 20 Feb 2023

Cited by 67 | Viewed by 4407

Abstract

Background and Objectives: Little information is available on the role of Vitamin D as a micro-nutrient deficiency with masticatory muscle efficiency and its effect on the function of removable prosthesis. The aim of this study was to evaluate the role of vitamin D on masticatory muscle activity among completely edentulous patients and its effect on the retention of removable complete dentures (RCDs). Materials and Methods: A non-randomized clinical control trial was conducted on completely edentulous patients (60.53 ± 7.01 years) in the Indian population between 2017 and 2019. Subjects were evaluated for temporomandibular disorders according to the Diagnostic Criteria for Temporomandibular Disorders (DC/TMD). Serum Vitamin D (S Vit D) levels, Ultrasonography (USG), and surface Electromyography (sEMG) readings of the masseter muscle were recorded at enrolment (Level 0), after 3 months of Vitamin D therapy (Level 3), and after consecutive 3 months of maintenance therapy, i.e., after 6 months from baseline (Level 6). The fabrication of new RCDs was done for all after the enrolment, and the retention of RCDs was assessed by asking a question regarding denture retention and asking respondents to mark their satisfaction on a 5-point Likert scale. Data were analysed using ANOVA, Paired’-test and Pearson correlation coefficients. A p-value less than 0.05 indicated a statistically significant association. Results: Between enrolment and a six-month follow-up, S Vit D levels showed an increase from 16.03 ± 5.68 ng/mL to 31.35 ± 9.28 ng/mL, showing an increase of 15.32 ± 9.38 ng/mL (95.57% rise). Statistically significant values were observed for USG and sEMG. Conclusions: Results showed that S Vit D affects masticatory muscle activity by improving its thickness and boosting its tonicity. Healthy muscles assist in the retention of RCDs, consequently aiding in mastication, speech, and phonetics, hence improving patient satisfaction. Clinical implication: Acknowledging the fact that the prevalence of Vitamin D deficiency is worldwide. We suggest Vitamin D therapy as a nutritional intervention among the elderly completely edentulous population, following dietary counselling, and consider Vitamin D therapy to be an adjunct to nutritional counselling for improving masticatory muscle activity and efficiency, which aids in RCD retention and stability. Consequently, improving oral health-related quality of life for individuals. Full article

(This article belongs to the Special Issue Experimental and Clinical Researches in Oral Medicine)

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17 pages, 2594 KiB

Open AccessArticle

A Placebo-Controlled Trial to Evaluate Two Locally Delivered Antibiotic Gels (Piperacillin Plus Tazobactam vs. Doxycycline) in Stage III–IV Periodontitis Patients

by Ioana Ilyes, Darian Rusu, Viorelia Rădulescu, Octavia Vela, Marius Ion Boariu, Alexandra Roman, Petra Surlin, Giorgios Kardaras, Simina Boia, Salvatore Chinnici, Holger Friedrich Rudolf Jentsch and Stefan-Ioan Stratul

Medicina 2023, 59(2), 303; https://doi.org/10.3390/medicina59020303 - 7 Feb 2023

Cited by 4 | Viewed by 3119

Abstract

Background and objectives: this study aims to evaluate the clinical and microbiological effects of a single subgingival administration of a locally delivered antibiotic gel containing piperacillin plus tazobactam and compare it with a slow-release doxycycline (14%) gel and a placebo gel, following subgingival instrumentation (SI) in patients with severe periodontitis. Materials and methods: sixty-four patients diagnosed with stage III–IV periodontitis were enrolled, were randomly assigned into three groups, and were treated additionally with a single subgingival administration of piperacillin plus tazobactam gel (group A); doxycycline gel (group B); and placebo gel (group C). The primary outcome variable was the change in mean probing pocket depth (PPD) 6 months after the intervention. Secondary outcome variables were changes in mean full-mouth bleeding score (FMBS); full-mouth plaque score (FMPS); overall bleeding index (BOP); pocket closure; and clinical attachment level (CAL), along with changes in the numbers of five keystone bacteria: Aggregatibacter actinomycetemcomitans (A.a.), Porphyromonas gingivalis (P.g.), Prevotella intermedia (P.i.), Tannerella forsythia (T.f.), and Treponema denticola (T.d.). Intergroup and intragroup differences were evaluated at 3 and 6 months. Results: at baseline, the three groups were comparable. An improvement in clinical parameters such as PPD, CAL, and BOP between groups was observed at 3 and 6 months, but without statistical significance (p > 0.05). At 6 months, the intragroup analysis showed a significant reduction in clinical parameters. Even though the piperacillin plus tazobactam group showed slightly higher PPD reduction, this was not statistically significant when compared to both control groups. Conclusions: The groups had similar results, and subgingival instrumentation can be executed without adjunctive antimicrobials, reducing the costs for the patient and the working time/load of the professional. Full article

(This article belongs to the Special Issue Experimental and Clinical Researches in Oral Medicine)

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12 pages, 2851 KiB

Open AccessArticle

The Influence of Chlorhexidine Gluconate Dentine Pre-Treatment on Adhesive Interface and Marginal Sealing

by Mihai-Octavian Boaru, Ionuț Tărăboanță, Simona Stoleriu, Sorin Andrian, Galina Pancu, Irina Nica, Irina-Georgeta Sufaru and Gianina Iovan

Medicina 2023, 59(2), 278; https://doi.org/10.3390/medicina59020278 - 31 Jan 2023

Cited by 4 | Viewed by 3531

Abstract

Background and Objectives: The aim of this in vitro study was to evaluate the combined effect of a 2% chlorhexidine aqueous solution and a universal adhesive system applied in self-etch and etch-and-rinse strategies on the composite resin–dentin interface. Materials and Methods: Class V cavities were prepared on the facial and lingual surfaces of forty caries-free molars extracted for orthodontic reasons. The samples were randomly divided into two groups corresponding to the used etching protocol: I—etch-and-rinse; II—self-etch. In each tooth, one cavity was assigned for the control subgroups -IA (n = 20) and IIA (n = 20)—adhesive only, and the opposite cavity was pretreated with a 2% chlorhexidine solution—Gluco CHeX Cerkamed—subgroups IB (n = 20) and IIB (n = 20). Both sets of groups were restored using a universal adhesive system (Single Bond Universal Adhesive, 3M-ESPE) and a bulk-fill composite resin (Filtek One Bulk Fill Restorative, 3M-ESPE). The roots and the pulp tissue were then removed, and a needle connected to a perfusor with 100 mL saline solution was used for pulp pressure simulation with a hydrostatic pressure of 20 cm H₂O. Cariogenic attack was simulated using a demineralizing solution for 3 days at a constant temperature of 25 °C. The teeth were then sectioned in a facial-lingual direction and the microleakages at the occlusal and cervical margins were registered and scored using an optical Carl-Zeiss AXIO Imager A1m microscope (Carl-Zeiss). The composite resin–dentin interface was analyzed using a SEM Vega Tescan LMH II. Statistical analysis was performed using the Kruskal–Wallis test with a significance level of p < 0.05. Results: Microleakage evaluation showed no significant differences among the study groups (p > 0.05). In subgroup IA, significant differences were recorded between occlusal and cervical margins (p < 0.05). Conclusions: Application of chlorhexidine on tooth substrate before using a universal bonding system in total etch or self-etch mode has no influence on the adhesive interface in the condition of cariogenic attack. The thickness of the adhesive resin layer seems to be less uniform when using chlorhexidine, but the morphological differences at the adhesive interface have no influence on the sealing capacity of the universal bonding system, regardless of the etching strategy. Full article

(This article belongs to the Special Issue Experimental and Clinical Researches in Oral Medicine)

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14 pages, 1750 KiB

Open AccessReview

A Contemporary Review of Clinical Factors Involved in Speech-Perspectives from a Prosthodontist Point of View

by Dana Gabriela Budală, Costin Iulian Lupu, Roxana Ionela Vasluianu, Nicoleta Ioanid, Oana Maria Butnaru and Elena-Raluca Baciu

Medicina 2023, 59(7), 1322; https://doi.org/10.3390/medicina59071322 - 18 Jul 2023

Cited by 6 | Viewed by 4401

Abstract

Background and Objectives: Learning to speak properly requires a fully formed brain, good eyesight, and a functioning auditory system. Defective phonation is the outcome of a failure in the development of any of the systems or components involved in speech production. Dentures with strong phonetic skills can be fabricated with the help of a dentist who has a firm grasp of speech production and phonetic characteristics. Every dentist strives to perfect their craft by perfecting the balance between the technical, cosmetic, and acoustic aspects of dentistry, or “phonetics”. The ideal prosthesis for a patient is one that not only sounds good but also functions well mechanically and aesthetically. Words are spoken by using articulators that alter their size and form. Conclusions: Therefore, a prosthesis should be made in such a way that it does not interfere with the ability to communicate. As a result, a prosthodontist has to have a solid grasp of how speech is made and the numerous parts that go into it. Full article

(This article belongs to the Special Issue Experimental and Clinical Researches in Oral Medicine)

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14 pages, 341 KiB

Open AccessReview

The Influence of Fixed Dental Prostheses on the Expression of Inflammatory Markers and Periodontal Status—Narrative Review

by Lucian Paul Dragomir, Flavia-Mirela Nicolae, Dorin Nicolae Gheorghe, Dora Maria Popescu, Iuliana Manuela Dragomir, Lidia Boldeanu, Virgil Mihail Boldeanu and Mihai Raul Popescu

Medicina 2023, 59(5), 941; https://doi.org/10.3390/medicina59050941 - 13 May 2023

Cited by 5 | Viewed by 2958

Abstract

A dental prosthesis will only be successful if the restoration lasts for a long period and does not cause any illness. The presence of permanent prosthetic restorations has been linked to an increased risk of periodontal infections, according to a large body of research that has been gathered. When chronic inflammation is brought on by fixed prosthetic constructions, both cellular and noncellular immunity are activated as adaptive immune mechanisms. It has previously been stated that both clinically adequate and inadequate restorations might cause gingival inflammation. Areas surrounding the abutment teeth presented periodontal pockets, attachment loss, congestion, bleeding on probing, and gingival hyperplasia after fixed restorations were removed. The depth of pockets, bleeding on probing, and bone loss are all closely correlated with disease’s severity and IL-1β concentration in gingival crevicular fluid; IL-1β shows higher values in disease sites than in healthy ones. hs-CRP and TNF-α blood levels showed a considerable reduction one day after fixed restorations were applied, in comparison with the pre-treatment values. Collaboration between prosthodontists and periodontists is essential for a good treatment outcome since it will increase the restoration’s lifespan, enhance periodontal health, and improve the quality of life for dental patients. Full article

(This article belongs to the Special Issue Experimental and Clinical Researches in Oral Medicine)

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