Medicina, Volume 61, Issue 8
2025 August - 189 articles
Cover Story: Alzheimer’s disease research is rapidly shifting from late-stage diagnosis to early detection and precision therapies. This figure illustrates the evolving Alzheimer’s disease landscape, emphasizing the shift from diagnosis to treatment. Early biomarkers, including tau hyperphosphorylation, genetic mutations (APP, ApoE, and PSEN1), and β-amyloid aggregation, enable earlier detection. Neuroimaging tools such as PET and MRI improve diagnostic accuracy. On the therapeutic side, disease-modifying agents like monoclonal antibodies (Lecanemab, Aducanumab), nanoparticles, and focused ultrasounds are highlighted as emerging interventions. Together, these advances can enable the earlier diagnosis and more effective treatment of Alzheimer’s disease. View this paper - Issues are regarded as officially published after their release is announced to the table of contents alert mailing list .
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