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Personalized Medicine in Dermatology: Current Status and Challenges
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Personalized Medicine in Dermatology: Current Status and Challenges

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Dermatology".

Deadline for manuscript submissions: 31 October 2026 | Viewed by 2205

Editors

Dr. Lidia Sacchelli

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Guest Editor
1. Dermatology Unit, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Policlinico S. Orsola-Malpighi, 40138 Bologna, Italy
2. Department of Medical and Surgical Sciences, Alma Mater Studiorum University of Bologna, 40138 Bologna, Italy
Interests: acne; psoriasis; biotechnological therapies; quality of life and ethical communication
Special Issues, Collections and Topics in MDPI journals
Dr. Michelangelo La Placa

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Guest Editor
Dermatology Division, Department of Experimental, Diagnostic and Specialty Medicine, University of Bologna, 40126 Bologna, Italy
Interests: dermatology
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Personalized medicine is transforming dermatology by moving from generalized treatments to tailored approaches based on individual clinical, genetic, and lifestyle profiles. This is especially important in chronic inflammatory conditions such as psoriasis, acne, and hidradenitis suppurativa, where patient variability is considerable.

This Special Issue aims to explore the current landscape and future of personalized medicine in dermatology. We seek to highlight how precision strategies can improve therapeutic outcomes, reduce side effects, and enhance patient quality of life.

Advancements in biotechnology, pharmacogenomics, and digital health are driving more accurate diagnoses, treatment monitoring, and customized care, paving the way for truly patient-centered dermatology.

We welcome original research, reviews, and clinical perspectives on personalized dermatology. Relevant topics include biomarkers, treatment algorithms, targeted therapies, digital tools, patient-reported outcomes, and real-world applications of precision medicine.

You may choose our Joint Special Issue in JPM.

Dr. Lidia Sacchelli
Dr. Michelangelo La Placa
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-anonymized peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • psoriasis
  • quality of life
  • acne
  • hidradenitis suppurativa
  • biotechnological therapies
  • personalized medicine
  • autoimmune skin diseases

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Published Papers (2 papers)

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Research

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19 pages, 1856 KB  
Article
Psychodermatologic Dimensions of Psoriasis: Perceived Burden, Help-Seeking Behavior and Openness to Supportive Care
by Bogdan Marian Tarcau, Dan Vata, Ioana Adriana Popescu, Doinita Temelie Olinici, Angelica Postu, Ioana Alina Halip, Dragos Florin Gheuca Solovastru, Madalina Mocanu, Marcel Alexandru Gaina and Laura Gheuca Solovastru
J. Clin. Med. 2026, 15(15), 5984; https://doi.org/10.3390/jcm15155984 - 31 Jul 2026
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Abstract
Background/Objectives: Psoriasis is a chronic immune-mediated dermatosis with an important psychodermatologic burden, in which psychological stress, perceived disease impact, stigma, and attitudes toward mental health care may influence patient support needs. Although psychological and psychiatric interventions are increasingly discussed in dermatology, patient [...] Read more.
Background/Objectives: Psoriasis is a chronic immune-mediated dermatosis with an important psychodermatologic burden, in which psychological stress, perceived disease impact, stigma, and attitudes toward mental health care may influence patient support needs. Although psychological and psychiatric interventions are increasingly discussed in dermatology, patient openness to different forms of supportive care, including music therapy, remains insufficiently characterized. This study aimed to characterize psychodermatologic burden and support-related attitudes among patients with psoriasis, with particular emphasis on openness to psychological counseling, psychiatric care, and music therapy-based support, and to explore the factors associated with these attitudes. Methods: In this single-center cross-sectional study, 102 adults with cutaneous or nail psoriasis completed an original self-administered questionnaire between July 2023 and January 2025. Results: Most participants perceived stress as related to psoriasis onset or worsening (86.3%) and considered dermatologist guidance toward psychological or psychiatric support beneficial (80.4%). Psychological counseling was the most accepted supportive intervention (75.5%), followed by music therapy (54.9%) and psychiatric consultation (48.0%), while previous psychological or psychiatric care was reported by 22.5%. Willingness to seek psychological support was independently associated with perceived psoriasis impact, whereas willingness to seek psychiatric support was associated with perceived stress impact. Awareness of music therapy was associated with higher educational level. Willingness to try music therapy was associated with high perceived stress impact, higher educational level, music listening, and awareness of music therapy. Conclusions: Patients with psoriasis frequently perceive stress as relevant to their disease and show variable openness to supportive care. These findings support an individualized psychodermatologic approach in which dermatologists may help identify patients receptive to psychological, psychiatric, or music therapy-based interventions. Full article
(This article belongs to the Special Issue Personalized Medicine in Dermatology: Current Status and Challenges)
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Review

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20 pages, 1198 KB  
Review
Glycemic Instability and Skin Health: Metabolic Mechanisms Linking Dietary Patterns with Cutaneous Dysfunction
by Paulina Cebulla, Emilia Czempik, Hanna Wilk, Iwona Turkowska, Przemysław Domaszewski and Karolina Chilicka-Hebel
J. Clin. Med. 2026, 15(15), 5830; https://doi.org/10.3390/jcm15155830 - 25 Jul 2026
Viewed by 1547
Abstract
Dietary patterns associated with high glycemic load and recurrent postprandial glucose excursions may influence skin physiology through mechanisms involving oxidative stress, insulin–IGF-1 signaling, chronic low-grade inflammation, and advanced glycation end product (AGE) formation. Disturbances in glucose homeostasis have been associated with alterations in [...] Read more.
Dietary patterns associated with high glycemic load and recurrent postprandial glucose excursions may influence skin physiology through mechanisms involving oxidative stress, insulin–IGF-1 signaling, chronic low-grade inflammation, and advanced glycation end product (AGE) formation. Disturbances in glucose homeostasis have been associated with alterations in epidermal barrier integrity, sebaceous gland activity, extracellular matrix remodeling, and tissue repair processes. These mechanisms have been investigated primarily in relation to several dermatological conditions, particularly acne vulgaris, impaired wound healing, xerosis, and skin aging. This narrative review summarizes current evidence regarding the relationship between glycemic dysregulation and skin health, with emphasis on metabolic and molecular pathways potentially involved in cutaneous dysfunction. To reflect the current strength of evidence, mechanistic studies, observational studies, and clinical investigations are distinguished throughout this review whenever possible. Particular focus is placed on postprandial glycemic variability, oxidative stress, hormonal signaling, and glycation-related tissue damage. Current evidence supports biologically plausible associations between metabolic dysregulation and several aspects of skin dysfunction, although direct evidence specifically addressing glycemic variability remains limited. Most available studies are observational or mechanistic in nature, and relatively few clinical investigations have evaluated dermatological outcomes directly. Further research is needed to clarify the clinical relevance of glycemic-targeted dietary and metabolic interventions in dermatology. Full article
(This article belongs to the Special Issue Personalized Medicine in Dermatology: Current Status and Challenges)
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