Therapeutic Strategies for Obesity–Metabolic Syndrome–Diabetes Continuum
A Special Issue of Journal of Clinical Medicine (ISSN 2077-0383) belonging to the section "Endocrinology & Metabolism".
Deadline for manuscript submissions: 30 October 2026 | Viewed by 866
Editors
2. Topolšica Hospital, Topolšica 64, 3326 Topolšica, Slovenia
3. Faculty of Medicine, University of Ljubljana, Vrazov trg 2, 1000 Ljubljana, Slovenia
Interests: metabolic syndrome; obesity; diabetes
2. Faculty of Medicine, University of Ljubljana, Vrazov trg 2, 1000 Ljubljana, Slovenia
Interests: type 2 diabetes; type 1 diabetes; inflammatory diseases
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
The pathophysiological trajectory extending from obesity to insulin resistance, metabolic syndrome (MetS), and ultimately Type 2 Diabetes Mellitus (T2DM) constitutes one of the most pressing global health crises. This "continuum" is not a linear progression, but a complex, reciprocal network of dysfunctions driven by chronic low-grade inflammation, lipotoxicity, gut microbiome dysbiosis, and epigenetic susceptibility. Despite the proliferation of pharmacologic agents, the increasing prevalence of these interconnected conditions requires a fundamental reappraisal of diagnostic frameworks and therapeutic paradigms.
This Special Issue aims to bridge the translational gap between basic science and clinical practice by interrogating cutting-edge therapeutic strategies that target the shared molecular substrates of the Obesity–Metabolic Syndrome–Diabetes continuum. We seek to highlight disease-modifying interventions that transcend symptomatic management—specifically strategies capable of disrupting the pathogenic loop, restoring metabolic flexibility, and mitigating target organ damage (cardiovascular, renal, and hepatic).
We invite original research, systematic reviews, and clinical perspectives focusing on the following:
- Next-generation pharmacotherapeutics (e.g., dual/triple agonists, novel molecular targets);
- Molecular mechanisms of adipose tissue dysfunction and insulin signaling;
- Metabolic surgery and endoscopic interventions as disease-modifying therapies;
- Clinical management and therapeutic barriers;
- Bio-behavioral and nutritional interventions, including chrononutrition;
- Modulation of the gut–metabolism axis;
- Precision medicine: Biomarkers for risk stratification and phenotypic clustering;
- Management of sequelae, with specific emphasis on MASLD/MASH and atherosclerotic cardiovascular disease (ASCVD).
By synthesizing insights from endocrinology, cardiology, gastroenterology, this issue aspires to delineate a roadmap for attenuating the metabolic continuum and optimizing patient outcomes.
Dr. Jana Makuc
Dr. Miodrag Janić
Guest Editors
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-anonymized peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- obesity
- metabolic syndrome
- type 2 diabetes mellitus
- multi-receptor agonists
- adipose tissue dysfunction
- metabolic surgery
- chrononutrition
- gut-metabolism axis
- metabolic phenotyping
- MASLD
Benefits of Publishing in a Special Issue
- Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
- Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
- Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
- External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
- Reprint: MDPI Books provides the opportunity to republish successful Special Issues in book format, both online and in print.
Further information on MDPI's Special Issue policies can be found here.
