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Journal of Clinical Medicine publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Non-Pharmacological Therapies and Exercise Interventions in Clinical Populations submission deadline 20 Apr 2027 | 4 articles | Viewed by 4235 | Submission Open
Keywords: non-pharmacological interventions; physiotherapy approaches; physical activity; acute and chronic diseases; acute and chronic pain
(This special issue belongs to the Section Clinical Rehabilitation)
Clinical Outcomes of Glaucoma Surgery: Visual Acuity, Effectiveness and Quality of Life submission deadline 20 Apr 2027 | 6 articles | Viewed by 3837 | Submission Open
Keywords: glaucoma surgery; visual acuity; intraocular pressure; surgical outcomes; trabeculectomy; microinvasive glaucoma surgery; postoperative complications; functional vision
(This special issue belongs to the Section Ophthalmology)
Infectious Diseases and Host Responses: Clinical, Immunological, and Outcome-Orientated Perspectives
edited by
submission deadline 20 Apr 2027 | 3 articles | Viewed by 3599 | Submission Open
Keywords: microbiology; infection; resistance; epidemiology; microbiome; prevention; therapy
(This special issue belongs to the Section Infectious Diseases)
Anesthesia and Intensive Care: Clinical Practices and Prospects
edited by
submission deadline 20 Apr 2027 | 4 articles | Viewed by 3542 | Submission Open
Keywords: artificial intelligence; clinical decision support; perioperative risk stratification; perioperative patient safety; hemodynamic optimization
(This special issue belongs to the Section Intensive Care)
Clinical Therapeutic Advances of Mitral Regurgitation
edited by Angelo Squeri
submission deadline 20 Apr 2027 | 4 articles | Viewed by 3424 | Submission Open
Keywords: mitral regurgitation; mitral valve prolapse; cardiovascular interventions; heart surgery; echocardiography; mag-netic resonance imaging; computed tomography
(This special issue belongs to the Section Cardiovascular Medicine)
Enhancing and Rehabilitation of Gait and Mobility in Chronic Stroke submission deadline 20 Apr 2027 | 1 articles | Viewed by 3204 | Submission Open
Keywords: chronic stroke; gait rehabilitation; mobility; physical therapy; technology-assisted interventions; assessment
(This special issue belongs to the Section Clinical Neurology)
Advances in the Diagnosis and Management of Age-Related Macular Degeneration: 3rd Edition
edited by Tsutomu Yasukawa
submission deadline 20 Apr 2027 | 4 articles | Viewed by 3050 | Submission Open
Keywords: age-related macular degeneration; angiography; anti-vascular endothelial growth factor therapy; geographic atrophy; macular neovascularization; multimodal imaging; ophthalmology; optical coherence tomography; photodynamic therapy; retinal pigment epithelium
(This special issue belongs to the Section Ophthalmology)
Cardiovascular Prevention and Epidemiology: Innovations and Insights Bridging Research and Practice for Effective Risk Reduction
edited by and Maria Maiello
submission deadline 20 Apr 2027 | 3 articles | Viewed by 2982 | Submission Open
Keywords: cardiovascular prevention; risk reduction; epidemiology; innovations; risk stratification; population health
(This special issue belongs to the Section Cardiovascular Medicine)
Orthopaedic Trauma and Bone Healing: Recent Advances and Future Perspectives
edited by Gheorghe Tomoaia and Daniel Oltean-Dan
submission deadline 20 Apr 2027 | 4 articles | Viewed by 2453 | Submission Open
Keywords: orthopaedic trauma; fractures; minimally invasive fixation; bone healing; biomaterials; periprosthetic fractures; artificial intelligence; rehabilitation; complications; orthopaedic surgery
(This special issue belongs to the Section Orthopedics)
Advances in the Management of Cervical Spine Trauma submission deadline 20 Apr 2027 | 3 articles | Viewed by 2315 | Submission Open
Keywords: cervical spine trauma; cervical fracture; high cervical injury; subaxial injury; surgical management; occipitocervical fusion; C1 fracture; C2 fracture; spinal stability; trauma imaging; spinal cord injury; neurological outcome
(This special issue belongs to the Section Orthopedics)
Clinical Advances in Geriatric Acute Care: Multimorbidity, Frailty, and Integrated Diagnostics submission deadline 20 Apr 2027 | 3 articles | Viewed by 2281 | Submission Open
Keywords: geriatric medicine; frailty; multidimensional assessment; lung ultrasound; point-of-care ultrasound; acute care of older adults; transitional care
(This special issue belongs to the Section Geriatric Medicine)
Endocrine Surgery: Current Treatment and Future Options
edited by Pietro Princi and
submission deadline 20 Apr 2027 | 1 articles | Viewed by 2279 | Submission Open
Keywords: endocrine surgery; thyroid surgery; parathyroid surgery; adrenal gland surgery; neuroendocrine neoplasms; thyroid cancer; thyroid cancer treatment; surgical endocrinology; robotic endocrine surgery; laparoscopic adrenalectomy; ret-roperitoneoscopic adrenalectomy; parathyroidectomy; benign thyroid disease; thyroid ablation
(This special issue belongs to the Section General Surgery)
From Clinical Diagnosis to Effective Treatment of Cardiomyopathy submission deadline 20 Apr 2027 | 2 articles | Viewed by 2028 | Submission Open
Keywords: hypertrophic cardiomyopathy; dilated cardiomyopathy; non-ischemic cardiomyopathy; cardiac MRI; PET/CT; PET/MRI; cardiac imaging; sudden cardiac death
(This special issue belongs to the Section Cardiology)
Advances in Trauma and Orthopedic Surgery: 3rd Edition submission deadline 20 Apr 2027 | 2 articles | Viewed by 1911 | Submission Open
Keywords: trauma; fracture; fracture fixation; osteosynthesis; biomechanics; bone; approach; nonunion; joint replacement; outcome
(This special issue belongs to the Section Orthopedics)
Advances in Cardiac Surgery: Techniques, Outcomes, and Innovations
edited by , Horatiu Suciu and
submission deadline 20 Apr 2027 | 3 articles | Viewed by 1898 | Submission Open
Keywords: endoscopic cardiac surgery; minimally invasive cardiac surgery; MIMS; mini-AVR; MIDCAB; TCRAT; LVAD; heart transplant; congenital heart disease
(This special issue belongs to the Section Cardiology)
Spine Surgery and Postoperative Management
edited by Mitchell K. Ng
submission deadline 20 Apr 2027 | 3 articles | Viewed by 1652 | Submission Open
Keywords: spine surgery; perioperative care; enhanced recovery after surgery (ERAS); multimodal analgesia; opioid-sparing strategies; neuromonitoring; perioperative optimization
(This special issue belongs to the Section Orthopedics)
New Developments and Challenges in Assisted Reproductive Technology
edited by and
submission deadline 20 Apr 2027 | 1 articles | Viewed by 1604 | Submission Open
Keywords: assisted reproductive technology; in vitro fertilization; clinical protocols and innovations; embryo selection and evaluation; ethnicity and reproductive outcomes; live birth; cryopreservation and fertility preservation; maternal and offspring health outcomes; global perspectives in reproductive medicine
(This special issue belongs to the Section Obstetrics & Gynecology)
Diagnosis and Clinical Management in Hematologic Oncology
edited by Sunil Lakhwani and José María Raya-Sánchez
submission deadline 20 Apr 2027 | 3 articles | Viewed by 1599 | Submission Open
Keywords: hematologic malignancies; lymphoma; multiple myeloma; acute leukemia; myeloproliferative neoplasms; molecular diagnostics; targeted therapy; immunotherapy; prognostic biomarkers; clinical management
(This special issue belongs to the Section Hematology)
Clinical Applications and Surgical Integration of Advanced Ophthalmic Imaging
edited by Katarzyna Nowomiejska
submission deadline 20 Apr 2027 | 2 articles | Viewed by 1562 | Submission Open
Keywords: ophthalmic imaging; retina; intraoperative OCT; personalized treatment; clinical applications
(This special issue belongs to the Section Ophthalmology)
Heart Failure and Transplant Cardiology: Latest Advances and Prospects
edited by Monika Budnik
submission deadline 20 Apr 2027 | 2 articles | Viewed by 1520 | Submission Open
Keywords: heart failure; heart transplantation; bridge to transplant; mechanical circulatory support; cardiomyopathies
(This special issue belongs to the Section Cardiology)
Electrotherapy and Electrodiagnostic in Modern Rehabilitation Medicine: Current Evidence, Clinical Applications, and Future Perspectives
edited by Cristina Octaviana Daia
submission deadline 20 Apr 2027 | 1 articles | Viewed by 1471 | Submission Open
Keywords: electrotherapy; physical and rehabilitation medicine; rehabilitation technologies; neurorehabilitation; cancer rehabilitation; electromyography; nerve conduction studies; musculoskeletal ultrasound; photobiomodula-tion; neuromuscular electrical stimulation; therapeutic ultrasound; extracorporeal shockwave therapy; electromagnetic field therapy; TECAR therapy
(This special issue belongs to the Section Clinical Rehabilitation)
Endometriosis: Advances in Diagnosis, Treatment, and Long-Term Outcomes
edited by
submission deadline 20 Apr 2027 | 2 articles | Viewed by 1421 | Submission Open
Keywords: endometriosis; diagnosis and biomarkers; medical and surgical treatment; fertility and reproductive outcomes; pain management; quality of life; long-term follow-up
(This special issue belongs to the Section Obstetrics & Gynecology)
Clinical Advances in Hearing Loss: Diagnosis, Treatment, and Management
edited by
submission deadline 20 Apr 2027 | 2 articles | Viewed by 1009 | Submission Open
Keywords: hearing loss; deafness; bone conduction implants; middle ear implants; cochlear implants; myringoplasty; tympanoplasty; stapedotomy; ossicular chain reconstruction; imaging; audiological diagnostic
(This special issue belongs to the Section Otolaryngology)
Contemporary Coronary Intervention: Innovation, Evidence, and Patient-Centred Outcomes
edited by Kevin Liou
submission deadline 20 Apr 2027 | 1 articles | Viewed by 964 | Submission Open
Keywords: percutaneous coronary interventions; coronary imaging; coronary physiology; precision medicine; CHIP PCI; stent-less technologies; clinical outcomes; pharmacotherapy in PCI; biomarkers; artificial intelligence in PCI; sustainability in PCI
(This special issue belongs to the Section Cardiology)
Advanced Coronary Physiology and Imaging-Guided Percutaneous Cardiovascular Interventions: Treatment Approaches and Outcomes
edited by Ioannis Skalidis
submission deadline 20 Apr 2027 | 1 articles | Viewed by 880 | Submission Open
Keywords: acute coronary syndromes; chronic coronary syndromes; coronary physiology; intravascular imaging; artificial in-telligence; percutaneous coronary intervention; complex coronary disease
(This special issue belongs to the Section Cardiology)
Current Trends and Progress in Eating Disorders and Obesity Management
edited by Davide Gravina, and
submission deadline 20 Apr 2027 | 1 articles | Viewed by 862 | Submission Open
Keywords: eating disorders; anorexia nervosa; bulimia nervosa; binge-eating disorder; ARFID; obesity; neuromodulation; biomarkers; gut microbiome; pharmacological interventions; incretin receptor agonists; GLP-1; metreleptin; psychedelics
(This special issue belongs to the Section Mental Health)
Spine Surgery: Clinical Advances and Future Directions—2nd Edition
edited by Eun-Sang Kim and
submission deadline 20 Apr 2027 | 1 articles | Viewed by 798 | Submission Open
Keywords: spine surgery; back pain; endoscopic spine surgery; cage implantation; neck pain
(This special issue belongs to the Section Clinical Neurology)
Physiotherapy: Multidisciplinary Interventions and Digital Health submission deadline 20 Apr 2027 | 1 articles | Viewed by 791 | Submission Open
Keywords: physiotherapy; rehabilitation; physical medicine; digital health; telemedicine; virtual reality; augmented reality; artifi-cial intelligence; robotic rehabilitation; wearable sensors; VR for educative goals; musculoskeletal, neurological, cognitive, pediatric, pulmonary, cardiac and gyneco-obstetric disorders; fibromyalgia syndrome; chronic pain; older adults
(This special issue belongs to the Section Clinical Rehabilitation)
Advances in Diagnosis, Monitoring, and Treatment of Myocardial Infarction
edited by
submission deadline 20 Apr 2027 | 1 articles | Viewed by 790 | Submission Open
Keywords: myocardial infarction (MI); occlusion myocardial infarction (OMI); myocardial infarction with non-obstructive coronary arteries (MINOCA); diagnosis; monitoring; treatment
(This special issue belongs to the Section Cardiovascular Medicine)
Exploring Female Infertility: Advances, Challenges, and Emerging Solutions
edited by
submission deadline 20 Apr 2027 | 2 articles | Viewed by 773 | Submission Open
Keywords: infertility; female infertility; in vitro fertilization; PCOS; assisted reproductive technology
(This special issue belongs to the Section Obstetrics & Gynecology)
Breaking the Barrier: Early Detection of Pancreatic Ductal Adenocarcinoma (PDAC) submission deadline 20 Apr 2027 | 1 articles | Viewed by 767 | Submission Open
Keywords: pancreatic ductal adenocarcinoma (PDAC); pancreatic cancer; IPMN; PDAC screening; early PDAC detection; PDAC biomarkers; CT; NMR
(This special issue belongs to the Section Oncology)
Hepatobiliary–Pancreatic Surgery in the Era of Interventional Radiology
edited by
submission deadline 20 Apr 2027 | 1 articles | Viewed by 750 | Submission Open
Keywords: hepato-biliary–pancreatic surgery; interventional radiology; percutaneous biliary drainage; percutaneous pancre-atic drainage; portal vein embolization; tumor ablation; minimally invasive surgery; cryoablation; thermoablation
(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
Anterior Segment Disorders
edited by Itay Lavy and
submission deadline 20 Apr 2027 | 1 articles | Viewed by 728 | Submission Open
Keywords: anterior segment disorders; corneal disease; cataract surgery; ocular surface disease; surgical outcomes; surgical techniques; artificial intelligence in diagnosis; diagnostic imaging; pharmacological and surgical interventions; refractive errors; anterior uveitis; keratitis; corneal ectasia; quality of life
(This special issue belongs to the Section Ophthalmology)
Current Practice and Future Directions in Hemodialysis and Peritoneal Dialysis
edited by
submission deadline 20 Apr 2027 | 1 articles | Viewed by 672 | Submission Open
Keywords: kidney replacement therapy; hemodialysis; peritoneal dialysis; dialysis nursing; continuous renal replacement therapy; incremental dialysis; decremental dialysis
(This special issue belongs to the Section Nephrology & Urology)
Current Concepts and Technological Innovations in Hepato-Pancreato-Biliary Surgery and Transplantation
edited by Michele Finotti and Francesco D’Amico
submission deadline 20 Apr 2027 | 1 articles | Viewed by 562 | Submission Open
Keywords: hepato-pancreato-biliary surgery; hepato-pancreato-biliary transplantation; pancreatic cancer; hepatobiliary cancer; vascular reconstruction; minimally invasive in hepato-pancreato-biliary surgery; robotic techniques; organ-preservation strategies
(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
Advances in Rehabilitation and Musculoskeletal Health
edited by , and Daniela Matei
submission deadline 20 Apr 2027 | 1 articles | Viewed by 542 | Submission Open
Keywords: musculoskeletal disorders; musculoskeletal rehabilitation; physical medicine and rehabilitation; pain management; osteoarthritis; functional recovery; disability assessment; therapeutic exercise; physiotherapy; sports injuries; ultra-sound in rehabilitation; quality of life; well-being
(This special issue belongs to the Section Clinical Rehabilitation)
Advances and Future Perspectives for Transcatheter Aortic Valve Replacement (TAVR)
edited by Kyriakos Spiliopoulos and Nikolaos Liaros
submission deadline 20 Apr 2027 | 1 articles | Viewed by 523 | Submission Open
Keywords: aortic stenosis; aortic valve replacement; transcatheter aortic valve replacement (TAVR); “Valve in Valve” procedure; TAVR-endocarditis; TAVR-durability; TAVR-design; cardiovascular imaging
(This special issue belongs to the Section Cardiology)
Novel Approaches in Obsessive–Compulsive and Related Spectrum Disorders
edited by and Andrea D. Guastello
submission deadline 20 Apr 2027 | 1 articles | Viewed by 481 | Submission Open
Keywords: OCD; misophonia; hoarding; tic disorders; assessment; treatment
(This special issue belongs to the Section Mental Health)
Emerging Technologies in Foot and Ankle Care: From Advanced Diagnosis to Innovative Treatment
edited by Jaehwang Song
submission deadline 20 Apr 2027 | 1 articles | Viewed by 388 | Submission Open
Keywords: foot; ankle; tendon; ligament; disease; MIS; deformity correction; flatfoot; cavovarus foot; WBCT
(This special issue belongs to the Section Orthopedics)
Precision Neuroimaging in Mental and Behavioral Health Research
edited by Thomas Vanicek and Arkadiusz Komorowski
submission deadline 20 Apr 2027 | Viewed by 375 | Submission Open
Keywords: psychiatry; neuroimaging; addiction; substance use disorders (SUD); attention deficit hyperactivity disorder (ADHD); imaging genomics; imaging transcriptomics
(This special issue belongs to the Section Mental Health)
The Liver–Kidney Axis in Metabolic Diseases: Biomarkers and Clinical Implications
edited by
submission deadline 20 Apr 2027 | Viewed by 366 | Submission Open
Keywords: liver; kidney; cross-organ crosstalk; mechanisms; biomarkers; metabolic diseases; clinical implications
(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
Clinical Advances in Adult Deformities and Spinal Disorders: Surgical Treatment and Pre- and Post-Operative Re-Habilitation
edited by
submission deadline 20 Apr 2027 | Viewed by 350 | Submission Open
Keywords: scoliosis; spine; kyphosis; degenerative spine; spine surgery
(This special issue belongs to the Section Orthopedics)
Current Trends and Innovations in Coronary Artery Disease and Myocardial Ischemia: Second Edition
edited by
submission deadline 20 Apr 2027 | Viewed by 330 | Submission Open
Keywords: coronary artery disease; fractional flow reserve; invasive coronary angiography; cardiac CT; cardiac MRI
(This special issue belongs to the Section Cardiovascular Medicine)
Personalised and Precision Pharmacotherapy: Data-Driven Therapeutic Optimisation in Real-World Clinical Practice submission deadline 20 Apr 2027 | Viewed by 311 | Submission Open
Keywords: precision pharmacotherapy; personalised medicine ; pharmacokinetics and pharmacodynamics ; therapeutic drug ; monitoring real-world evidence ; multimorbidity ; medication appropriateness ; model-informed precision dosing; does individualisation; clinical decision support
(This special issue belongs to the Section Pharmacology)
Advances in Clinical Oncologic Diagnostic and Interventional Radiology
edited by Alberta Cappelli
submission deadline 20 Apr 2027 | 1 articles | Viewed by 306 | Submission Open
Keywords: artificial intelligence; oncological imaging; hybrid imaging; endovascular radiology; percutaneous procedures; radiomics; MRI; CT; PET/CT; photon counting CT; cone-beam CT
(This special issue belongs to the Section Nuclear Medicine & Radiology)
Clinical Approaches of Intracranial Aneurysm and Subarachnoid Hemorrhage
edited by Sylvia Bele
submission deadline 20 Apr 2027 | Viewed by 301 | Submission Open
Keywords: aSAH; clipping or coiling; extracranial complications; cerebral vasospasm; ICU treatment
(This special issue belongs to the Section Clinical Neurology)
Recent Advances in Hypercholesterolemia
edited by Ana Catarina Alves
submission deadline 20 Apr 2027 | Viewed by 294 | Submission Open
Keywords: hypercholesterolemia; cardiovascular risk; molecular diagnostics; variants of uncertain significance (VUS); functional characterisation; precision medicine; lipid-lowering therapy
(This special issue belongs to the Section Endocrinology & Metabolism)
From Imaging to Intervention: Modern Approaches in Spine Disorders Management submission deadline 20 Apr 2027 | Viewed by 292 | Submission Open
Keywords: adolescent idiopathic scoliosis (AIS); spinal fusion; Cobb angle; bracing; skeletal maturity; radiographic imaging; multidisciplinary management
(This special issue belongs to the Section Orthopedics)
Targeting Extravalvular Burden Associated with Valvular Heart Disease
edited by
submission deadline 20 Apr 2027 | Viewed by 276 | Submission Open
Keywords: valvular heart disease; systemic disorder; extravalvular burden; valve dysfunction; valve intervention; multimodality imaging
(This special issue belongs to the Section Cardiology)
Hypertension in Adults: Current Updates on Diagnosis, Treatment and Management—Second Edition
edited by Emelina Stambolliu and Antonios A. Argyris
submission deadline 20 Apr 2027 | Viewed by 270 | Submission Open
Keywords: essential hypertension; nighttime blood pressure; blood pressure measurement; blood pressure management; blood pressure medical treatment; hypertension thresholds
(This special issue belongs to the Section Vascular Medicine)
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