jcm-logo

Journal Browser

Journal Browser

New Developments and Challenges in Assisted Reproductive Technology

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Obstetrics & Gynecology".

Deadline for manuscript submissions: 20 August 2026 | Viewed by 514

Special Issue Editors

OriginElle Fertility Clinic & Women's Health Centre, Montreal, QC, Canada
Interests: assisted reproductive technology; in vitro fertilization; reproductive epidemiology; polycystic ovary syndrome; maternal and offspring health outcomes; infertility; disparity in reproductive outcomes; cohort studies; randomized controlled trials; systematic review and meta-analysis
CReATe Fertility Centre, Toronto, ON, Canada
Interests: assisted reproductive technology; in vitro fertilization; clinical protocols and innovations; embryo selection and evaluation; reproductive epidemiology; polycystic ovary syndrome; design and validation of novel technologies in reproductive medicine; application of virtual reality systems to enhance patient experience during oocyte retrieval; development of non-invasive techniques for three-dimensional mapping and evaluation of human embryos; cryo-preservation and fertility preservation; reproductive genetics and testing; maternal and offspring health outcomes; global perspectives in reproductive medicine

Special Issue Information

Dear Colleagues,

Assisted reproductive technology (ART) is undergoing rapid transformation, driven by innovations that enhance treatment effectiveness, safety, and accessibility. Advances in clinical protocols, laboratory techniques, and reproductive medicine are reshaping infertility care and improving patient outcomes worldwide. Emerging approaches such as enhanced embryo culture systems, artificial intelligence–supported embryo selection, and non-invasive assessments of oocyte and embryo quality are expanding opportunities for individualized care and refining clinical decision-making. Improvements in cryopreservation, genetic testing, and fertility preservation strategies further broaden the scope of ART, offering new possibilities for patients with diverse medical and reproductive needs.

Despite these advances, significant challenges remain. Variations in treatment outcomes across patient groups, differences in healthcare access, and disparities related to regional availability of services require further clinical investigation. Extended follow-up of ART-conceived children and comprehensive assessment of maternal health outcomes remain essential for evaluating long-term reproductive safety and efficacy. Additionally, emerging research on male and female reproductive factors continues to add critical dimensions to understanding ART.

This Special Issue seeks to bring together cutting-edge research and critical perspectives on the future of assisted reproduction. Contributions from clinicians, researchers, embryologists, andrologists, epidemiologists, and graduate students are invited to address innovations, outcomes, and challenges that will inform clinical practice and guide future directions in reproductive medicine.

Dr. Shuqin Wei
Dr. Justin Tan
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • assisted reproductive technology
  • in vitro fertilization
  • clinical protocols and innovations
  • embryo selection and evaluation
  • ethnicity and reproductive outcomes
  • live birth
  • cryopreservation and fertility preservation
  • maternal and offspring health outcomes
  • global perspectives in reproductive medicine

Benefits of Publishing in a Special Issue

  • Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
  • Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
  • Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
  • External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
  • Reprint: MDPI Books provides the opportunity to republish successful Special Issues in book format, both online and in print.

Further information on MDPI's Special Issue policies can be found here.

Published Papers (1 paper)

Order results
Result details
Select all
Export citation of selected articles as:

Other

16 pages, 1833 KB  
Systematic Review
Assisted Reproductive Technology and Cardiovascular Outcomes in Women: A Systematic Review and Meta-Analysis
by Shu Qin Wei, Wenwan Li, Nathalie Auger, Brian J. Potter, Gilles Paradis, Jessica Healy-Profitós and Seang-Lin Tan
J. Clin. Med. 2026, 15(8), 2844; https://doi.org/10.3390/jcm15082844 - 9 Apr 2026
Viewed by 325
Abstract
Background: Assisted reproductive technology has been linked to an increased risk of pregnancy-related cardiovascular complications, but the long-term cardiovascular outcome is poorly understood. This study aimed to assess whether women who use ART have an elevated long-term risk of adverse cardiovascular outcomes. Methods: [...] Read more.
Background: Assisted reproductive technology has been linked to an increased risk of pregnancy-related cardiovascular complications, but the long-term cardiovascular outcome is poorly understood. This study aimed to assess whether women who use ART have an elevated long-term risk of adverse cardiovascular outcomes. Methods: We conducted a systematic review and meta-analysis to examine the association between ART and long-term cardiovascular outcomes after pregnancy. We systematically searched MEDLINE, Embase, and the Cochrane Library for studies published by January 2026. We evaluated the methodological quality of included studies using the Newcastle-Ottawa Scale. We used random effects models to calculate pooled adjusted risk ratios (aRR) with 95% confidence intervals (CI) for the association of ART with cardiovascular outcomes. Results: We included thirteen studies comprising 553,331 patients who used ART and 37,826,591 patients who conceived spontaneously. All women achieved a live birth. Mean duration of follow-up after delivery was 8.4 ± 8.3 years. In models adjusted for age, parity, and comorbidity, ART was associated with a small increase in the risk of cardiovascular disease compared with spontaneous conception (aRR 1.18, 95% CI 1.03–1.35), but the association was attenuated when studies that had only 42 days of follow-up were excluded (aRR 1.13, 95% CI 0.99–1.29). ART was not associated with cardiac complications (aRR 0.94, 95% CI 0.82–1.08), stroke (aRR 1.20; 95% CI 0.93–1.55), hypertension (aRR 1.02; 95% CI 0.72–1.44), or venous thrombosis (aRR 1.27, 95% CI 0.97–1.67). Conclusions: Our findings suggest that women who achieve a live birth following ART do not appear to have an increased long-term risk of adverse cardiovascular outcomes. These results provide reassuring evidence for patient counseling regarding the long-term cardiovascular safety of ART among women with successful pregnancies. Further research that includes women who do not achieve a live birth is warranted to more fully characterize the potential long-term cardiovascular effects of ART across the entire spectrum of treatment outcomes. Full article
(This article belongs to the Special Issue New Developments and Challenges in Assisted Reproductive Technology)
Show Figures

Figure 1

Back to TopTop