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From Clinical Diagnosis to Effective Treatment of Cardiomyopathy

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Cardiology".

Deadline for manuscript submissions: 20 August 2026 | Viewed by 1051

Special Issue Editors


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Guest Editor
Division of Cardiology, Mount Sinai Fuster Heart Hospital, New York, NY 10025, USA
Interests: sports cardiology; cardiac imaging; arrhythmias; sudden cardiac death
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Cardiomyopathies represent a diverse group of cardiac disorders characterized by various inflammatory, infiltrative, and biomechanical mechanisms. Over the past decade, the field has experienced a fundamental transformation, from phenotypic descriptions to accurate clinical diagnoses based on advanced imaging, molecular profiling, and comprehensive risk stratification. Modern techniques such as cardiac MRI, computed tomography, and hybrid PET imaging enable earlier disease detection, better differentiation between physiological remodeling and pathological changes, and more precise prognostic assessments across the spectrum of cardiomyopathies. In parallel, therapeutic advances have expanded well beyond conventional management. Targeted pharmacotherapies, genotype-guided strategies, device interventions, and innovative disease-modifying treatments are increasingly facilitating personalized care, with demonstrable effects on symptoms, disease progression, and patient outcomes. Importantly, these diagnostic and therapeutic advancements highlight the importance of multidisciplinary collaboration and shared decision-making, particularly in managing complex phenotypes such as hypertrophic, inflammatory, and infiltrative cardiomyopathies.

This Special Issue, From Clinical Diagnosis to Effective Treatment of Cardiomyopathy, aims to highlight state-of-the-art approaches that bridge accurate diagnosis with meaningful clinical intervention. We welcome original research, reviews, and illustrative cases addressing advances in imaging, biomarkers, pathophysiology, and treatment strategies across the cardiomyopathy continuum. Through this collection, we hope to provide clinicians and researchers with practical, forward-looking perspectives that translate scientific progress into improved patient care.

You may choose our Joint Special Issue in Diagnostics.

Dr. Sanjay Sivalokanathan
Prof. Dr. Łukasz A. Małek
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • hypertrophic cardiomyopathy
  • dilated cardiomyopathy
  • non-ischemic cardiomyopathy
  • cardiac MRI
  • PET/CT
  • PET/MRI
  • cardiac imaging
  • sudden cardiac death

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Published Papers (1 paper)

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Review

27 pages, 1103 KB  
Review
Autoantibody Profiling in Cardiomyopathies: Toward Immune-Guided Risk Stratification and Therapy
by Alberto Marmai, Giovanni Civieri, Laura Iop, Marika Martini, Marta Vadori, Emanuele Cozzi and Francesco Tona
J. Clin. Med. 2026, 15(7), 2615; https://doi.org/10.3390/jcm15072615 - 29 Mar 2026
Viewed by 657
Abstract
Cardiomyopathies comprise a heterogeneous group of myocardial disorders characterized by structural and/or functional abnormalities in the absence of secondary causes of myocardial dysfunction. Although genetic determinants play a central role in many forms of the disease, incomplete penetrance and the frequent absence of [...] Read more.
Cardiomyopathies comprise a heterogeneous group of myocardial disorders characterized by structural and/or functional abnormalities in the absence of secondary causes of myocardial dysfunction. Although genetic determinants play a central role in many forms of the disease, incomplete penetrance and the frequent absence of identifiable pathogenic variants suggest that additional mechanisms contribute to disease onset and progression. Growing evidence supports the pathogenic role of autoimmune processes in several cardiomyopathy phenotypes. A spectrum of autoantibodies targeting cardiac self-antigens, including structural proteins, intercalated disc components, intracellular proteins such as calreticulin, and G protein-coupled receptors, has been identified in affected patients. Experimental and clinical data suggest that these autoantibodies may exert functional effects on cardiomyocyte signaling pathways and intercellular coupling, thereby promoting maladaptive remodeling, progressive ventricular dysfunction, and an increased risk of arrhythmias. Accordingly, autoantibody profiling may facilitate the identification of biologically distinct cardiomyopathy subsets with potential diagnostic and prognostic implications. From a therapeutic perspective, pathogenic autoantibodies can be removed from patient serum through plasmapheresis or immunoadsorption strategies, and these approaches have been associated with improvements in hemodynamic parameters and clinical outcomes in selected patients. Full article
(This article belongs to the Special Issue From Clinical Diagnosis to Effective Treatment of Cardiomyopathy)
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