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Journal of Clinical Medicine publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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AI in Maternal Fetal Medicine and Perinatal Management
edited by Ariel Many
submission deadline 20 Feb 2027 | 8 articles | Viewed by 14464 | Submission Open
Keywords: maternal fetal medicine; high-risk pregnancy; perinatal management; artificial intelligence (AI) in obstetrics; fetal growth abnormalities; preterm labor prediction
(This special issue belongs to the Section Obstetrics & Gynecology)
Advancements in Gait Rehabilitation: Innovative Approaches and Clinical Insights submission deadline 20 Feb 2027 | 9 articles | Viewed by 13218 | Submission Open
Keywords: sarcopenia; swallowing therapy; physical therapy; early mobilization; early rehabilitation; robot-assisted gait training; neurorehabilitation; wearable sensors
(This special issue belongs to the Section Clinical Rehabilitation)
Ultrasound-Guided Biopsy of Gynecologic Tumors: Technique and Clinical Application
edited by and Alexandros Daponte
submission deadline 20 Feb 2027 | 1 articles | Viewed by 12106 | Submission Open
Keywords: ultrasound-guided biopsy; gynecologic tumors; ovarian cancer; biopsy technique; precision diagnosis; endometrial lesions
(This special issue belongs to the Section Obstetrics & Gynecology)
Clinical Diagnosis and Management of Obstructive Sleep Apnea Syndrome submission deadline 20 Feb 2027 | 6 articles | Viewed by 10509 | Submission Open
Keywords: obstructive sleep apnea (OSA); apnea-hypopnea index (AHI); oxygen desaturation index (ODI); mandibular advancement device (MAD); polysomnography; upper airway; continuous positive airway pressure (C-PAP)
(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)
Sepsis: Clinical Advances and Practical Updates
edited by
submission deadline 20 Feb 2027 | 5 articles | Viewed by 8096 | Submission Open
Keywords: sepsis pathophysiology; host immune response; biomarkers for sepsis; early sepsis diagnosis; immunotherapy in sepsis; antimicrobial stewardship
(This special issue belongs to the Section Intensive Care)
Risk Factors in Neonatal Intensive Care submission deadline 20 Feb 2027 | 7 articles | Viewed by 7827 | Submission Open
Keywords: neonatal intensive care; infant birth; preterm; neonatal resuscitation; neonatal outcome; growth restriction; prenatal diagnosis; severe maternal pathology and its effects on a newborn; therapeutical hypothermia; parenteral nutrition; neonatal infection; retinopathy of prematurity
(This special issue belongs to the Section Clinical Pediatrics)
Pediatric Nephrology: Advances in the Diagnosis and Management of Pediatric Kidney Disorders submission deadline 20 Feb 2027 | 4 articles | Viewed by 7100 | Submission Open
Keywords: diagnosis; management; treatment; kidney disorders; chronic kidney disease; biomarkers; genetic testing; kidney; children; newborn
(This special issue belongs to the Section Nephrology & Urology)
Parkinson's Disease: Recent Advances in Diagnosis and Treatment submission deadline 20 Feb 2027 | 6 articles | Viewed by 7028 | Submission Open
Keywords: Parkinson’s disease; disease-modifying therapies; artificial intelligence; microbiome; alpha-synuclein; neuroimaging
(This special issue belongs to the Section Clinical Neurology)
Advances in the Personalized Management of Chronic Obstructive Pulmonary Disease (COPD)
edited by and Georgios Hillas
submission deadline 20 Feb 2027 | 5 articles | Viewed by 6216 | Submission Open
Keywords: artificial intelligence; biologics; biomarkers; diagnostics; oscillometry; COPD pharmacotherapy; imaging
(This special issue belongs to the Section Respiratory Medicine)
Rising Star: Advanced Physical Therapy and Expansion
edited by
submission deadline 20 Feb 2027 | 4 articles | Viewed by 5667 | Submission Open
Keywords: physical therapy; digital therapeutic technology; geriatric diseases; pediatric; psychology of physical therapies; clinical approach
(This special issue belongs to the Section Clinical Rehabilitation)
New Clinical Advances in Breast Reconstruction
edited by
submission deadline 20 Feb 2027 | 6 articles | Viewed by 5450 | Submission Open
Keywords: breast reconstruction; autologous (flap) reconstruction; implant-based reconstruction; microsurgery and perforator flaps; robotic surgery/endoscopic surgery; fat grafting (lipofilling); patient-reported outcomes; reconstructive surgical innovation
(This special issue belongs to the Section Plastic, Reconstructive and Aesthetic Surgery/Aesthetic Medicine)
Myopic Optic Neuropathy (MON) and Glaucomatous Optic Neuropathy (GON): Current Concepts and Clinical Implications
edited by
submission deadline 20 Feb 2027 | 5 articles | Viewed by 5203 | Submission Open
Keywords: myopic optic neuropathy; glaucomatous optic neuropathy; tilting; axonal transport; lamina cribrosa
(This special issue belongs to the Section Ophthalmology)
Innovations in the Clinical Management of Retinal Diseases: Emerging Therapies and Visual Rehabilitation submission deadline 20 Feb 2027 | 3 articles | Viewed by 4950 | Submission Open
Keywords: retinal diseases; macular degeneration; maculopathies; diabetic retinopathy; retinal vascular occlusions; retinitis pigmentosa
(This special issue belongs to the Section Ophthalmology)
Clinical Advances in Scoliosis and Spinal Disorders: Diagnosis and Management
edited by Tejas Subramanian
submission deadline 20 Feb 2027 | 4 articles | Viewed by 4927 | Submission Open
Keywords: spine surgery; adult spinal deformity; frailty; sarcopenia; muscle health; postoperative recovery; patient-reported outcomes
(This special issue belongs to the Section Orthopedics)
Innovations in Neurorehabilitation—2nd Edition
edited by
submission deadline 20 Feb 2027 | 3 articles | Viewed by 4682 | Submission Open
Keywords: clinical neurophysiology; neuroengineering; robotics; non-invasive transcranial brain stimulation; spinal stimula-tion; regenerative rehabilitation; neuroimaging; brain–computer interface; brain-spinal interface; virtual reality; higher-level cognitive functions; vision rehabilitation
(This special issue belongs to the Section Clinical Rehabilitation)
Ocular Surface Disease: Epidemiology, Diagnosis and Management submission deadline 20 Feb 2027 | 3 articles | Viewed by 4440 | Submission Open
Keywords: dry eye disease; risk factors; ocular surface disease; inflammatory biomarkers; anterior segment imaging; emerging therapies
(This special issue belongs to the Section Ophthalmology)
Advances in Hepatitis: Prevention, Treatment, and Global Health Impact submission deadline 20 Feb 2027 | 4 articles | Viewed by 4328 | Submission Open
Keywords: hepatitis B; hepatitis C; liver disease; direct-acting antivirals (DAAs); global health; public health policy; viral hepa-titis elimination; health disparities; cirrhosis; vaccination programs
(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
Clinical Advances in the Pharmacotherapy of Diabetes
edited by Jonathan Watanabe, and
submission deadline 20 Feb 2027 | 3 articles | Viewed by 4250 | Submission Open
Keywords: diabetes; microvascular complications; macrovascular complications; diabetes technology; pharmacoepidemiology; care delivery; novel therapies
(This special issue belongs to the Section Pharmacology)
Cardiovascular Imaging: Diagnosis and Therapeutic Guidance in Clinical Practice
edited by
submission deadline 20 Feb 2027 | 4 articles | Viewed by 4088 | Submission Open
Keywords: cardiovascular magnetic resonance; cardiac imaging; T1 and T2 mapping; myocardial tissue characterization; late gadolinium enhancement; ischemic heart disease; cardiomyopathies; valvular heart disease; therapeutic guidance; precision medicine; mitral valve prolapse
(This special issue belongs to the Section Cardiology)
Stroke Care: From Acute Interventions to Long-Term Recovery submission deadline 20 Feb 2027 | 2 articles | Viewed by 3687 | Submission Open
Keywords: cerebrovascular diseases; acute ischemic stroke; intravenous thrombolysis; endovascular thrombectomy; intracerebral hemorrhage; etiology; cerebral amyloid angiopathy; stroke rehabilitation
(This special issue belongs to the Section Clinical Neurology)
Clinical Research on Minimally Invasive Spine Surgery
edited by Daniel Fahim
submission deadline 20 Feb 2027 | 6 articles | Viewed by 3276 | Submission Open
Keywords: minimally invasive spine surgery; spine tumors; spine trauma; spine fractures; lumbar stenosis; lumbar spondylolisthesis; lumbar disc herniation; lumbar radiculopathy; thoracic disc herniations; cervical radiculopathy
(This special issue belongs to the Section Orthopedics)
Clinical Management of Patients Before and After Kidney Transplantation
edited by
submission deadline 20 Feb 2027 | 4 articles | Viewed by 3196 | Submission Open
Keywords: chronic kidney disease; kidney function; kidney replacement therapy; kidney transplantation; kidney graft survival; post-transplant complications
(This special issue belongs to the Section Nephrology & Urology)
Cardiotoxicity Within Cardio-Oncology: Clinical Advances from Prediction to Management submission deadline 20 Feb 2027 | 4 articles | Viewed by 3125 | Submission Open
Keywords: cardio-oncology; cardiotoxicity; cancer therapy–related cardiac dysfunction; heart failure in cancer patients; biomarkers; multimodality imaging; risk stratification; cardioprotection; cancer survivors' care; multidisciplinary approach
(This special issue belongs to the Section Cardiology)
Advanced Endoscopy and Imaging in Gastrointestinal Diseases submission deadline 20 Feb 2027 | 3 articles | Viewed by 3106 | Submission Open
Keywords: advanced endoscopy; gastrointestinal imaging; minimally invasive therapy; early diagnosis; image-guided intervention; surgical planning; patient outcomes; gastrointestinal diseases
(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
Current and Emerging Treatment Options in Chronic Liver Diseases
edited by Chandana B. Herath and Michael Praktiknjo
submission deadline 20 Feb 2027 | 2 articles | Viewed by 2919 | Submission Open
Keywords: liver disease; liver fibrosis; liver cirrhosis; portal hypertension; liver cancer; therapies; immunological therapies for liver cancer; diabetic liver; type 2 diabetes and obesity; spontaneous bacterial peritonitis
(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
Advances in Anterior Cruciate Ligament Injury Treatment
edited by
submission deadline 20 Feb 2027 | 3 articles | Viewed by 2846 | Submission Open
Keywords: anterior cruciate ligament (ACL) injury; ACL reconstruction techniques; nonoperative ACL treatment; ACL graft; knee biomechanics; return-to-sport assessment; ACL rehabilitation; neuromuscular and proprioceptive training; athletic injuries; performance-enhancing substances; reinjury prevention; psychological readiness; ACL performance testing; osteoarthritis risk
(This special issue belongs to the Section Orthopedics)
Thoracic Surgery Today: Innovations, Challenges, and Future Perspectives
edited by Jeffrey B. Velotta and
submission deadline 20 Feb 2027 | 4 articles | Viewed by 2792 | Submission Open
Keywords: thoracic surgery; minimally invasive thoracic surgery; innovation; esophageal surgery; robotic-assisted thoracic surgery; lung cancer; advanced techniques; thoracic surgical oncology; mediastinal surgery; mesothelioma surgery
(This special issue belongs to the Section General Surgery)
Clinical Management of Traumatic Brain Injury
edited by Adam James Wells and Peter Hutchinson
submission deadline 20 Feb 2027 | 4 articles | Viewed by 2782 | Submission Open
Keywords: traumatic brain injury; clinical management TBI; neurocritical care; neuromonitoring; trauma neurosurgery; artificial intelligence
(This special issue belongs to the Section Clinical Neurology)
New Technologies for Personalized Medicine in Head and Neck Surgery submission deadline 20 Feb 2027 | 4 articles | Viewed by 2657 | Submission Open
Keywords: personalized medicine; head and neck surgery; 3D printing; surgical navigation; artificial intelligence; computer-assisted surgery; regenerative medicine; precision oncology; craniofacial reconstruction; biomaterials; virtual surgical planning; genomics and proteomics; tissue engineering; functional rehabilitation
(This special issue belongs to the Section Otolaryngology)
Clinical Research Advances in Gynecologic Oncology
edited by
submission deadline 20 Feb 2027 | 2 articles | Viewed by 2614 | Submission Open
Keywords: ovarian cancer; endometrial cancer; breast cancer; molecular biology; gynecological cancers
(This special issue belongs to the Section Oncology)
Clinical Advances and Future Challenges for Occupational Health
edited by and Vincenza Pellicani
submission deadline 20 Feb 2027 | 3 articles | Viewed by 2259 | Submission Open
Keywords: work-related disease; precision medicine; gender differences; aging workforce; preventive strategies
(This special issue belongs to the Section Epidemiology & Public Health)
Chronic Kidney Disease: From Diagnosis to Treatment
edited by Debra Hain
submission deadline 20 Feb 2027 | 2 articles | Viewed by 2191 | Submission Open
Keywords: chronic kidney disease; type 2 diabetes; diabetic complications; hemodialysis; nephrology nursing; older adults; palliative care; therapy; hypertension
(This special issue belongs to the Section Nephrology & Urology)
Dental Care and Oral Health in Adolescents and Children
edited by
submission deadline 20 Feb 2027 | 2 articles | Viewed by 2179 | Submission Open
Keywords: oral health; oral diseases; diagnosis; dental treatment; treatment methods; general health; pediatric dentistry; special care dentistry; immunodeficiency; pediatric dental surgery
(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)
Clinical Management of Vitreous and Retinal Disorders
edited by Samuel Asanad
submission deadline 20 Feb 2027 | 2 articles | Viewed by 2066 | Submission Open
Keywords: OCT; OCTA; AMD; neurodegenerative disease; surgical techniques; retinal detachment; retinal blood flow; retinal biomarkers; gene therapy
(This special issue belongs to the Section Ophthalmology)
Clinical Advances and Challenges in Liver Transplantation: 3rd Edition
edited by
submission deadline 20 Feb 2027 | 2 articles | Viewed by 1999 | Submission Open
Keywords: liver transplantation (LT); elderly donors; steatotic livers; donors after circulatory death (DCD); hepatocellular carcinoma (HCC); perioperative management
(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
Obsessive–Compulsive Disorder: Clinical Advances and Future Perspectives—Second Edition
edited by Andrea Fagiolini
submission deadline 20 Feb 2027 | 2 articles | Viewed by 1957 | Submission Open
Keywords: obsessions–compulsions; anxiety; OCD symptoms; treatment options; functional impairment
(This special issue belongs to the Section Mental Health)
Therapeutic Advances in Hematological Malignancies: New Breakthroughs and Future Directions
edited by Seema Naik
submission deadline 20 Feb 2027 | 2 articles | Viewed by 1837 | Submission Open
Keywords: leukemia; lymphoma; myeloma; cell therapy; targeted therapy
(This special issue belongs to the Section Hematology)
Diagnosis and Management of Corneal Diseases
edited by Nicola Cardascia
submission deadline 20 Feb 2027 | 2 articles | Viewed by 1690 | Submission Open
Keywords: corneal surgery; lamellar keratoplasty; bioengineered corneal grafts; regenerative medicine; cell-based therapies; tissue-based therapies; Intraoperative imaging; corneal wound healing; lmmune modulation; graft survival; translational research; multimodal diagnostics; clinical outcomes; corneal transparency restoration; ophthalmic surgical innovation
(This special issue belongs to the Section Ophthalmology)
New Insights into Transcatheter Mitral Valve Therapy
edited by Antonio Sisinni and
submission deadline 20 Feb 2027 | 2 articles | Viewed by 1674 | Submission Open
Keywords: mitral regurgitation; transcatheter mitral valve therapy; TEER; TMVR; MitraClip; pascal; valve-in-valve; multimodality imaging; outcomes; structural heart interventions
(This special issue belongs to the Section Cardiovascular Medicine)
Arterial Stiffness and Cardiovascular Risk: New Advances and Challenges
edited by
submission deadline 20 Feb 2027 | 3 articles | Viewed by 1661 | Submission Open
Keywords: arterial stiffness; vascular aging; anti-inflammation; cardiovascular risk; personalized medicine
(This special issue belongs to the Section Cardiovascular Medicine)
Advances in Rhinosinusitis and Nasal Polyposis: From Emerging Trends and Therapeutic Opportunities to Surgery
edited by Gian Luca Fadda, Giovanni Cavallo and
submission deadline 20 Feb 2027 | 3 articles | Viewed by 1587 | Submission Open
Keywords: nasal polyps; chronic rhinosinusitis; asthma; endoscopic sinus surgery; anatomical variation; biologic treatment; type-2 inflammation; paranasal sinuses; CRSwNP; late response; long term; remission; dupilumab; control
(This special issue belongs to the Section Otolaryngology)
Coronary Artery Disease in the Era of Artificial Intelligence: Clinical Insights and Therapeutic Challenges
edited by Konstantinos Mourouzis
submission deadline 20 Feb 2027 | 1 articles | Viewed by 1507 | Submission Open
Keywords: coronary artery disease; myocardial ischemia; coronary imaging; revascularization; cardiometabolic risk; biomarkers; artificial intelligence; endothelial dysfunction; inflammation; arterial stiffness; antiplatelet therapy; heart failure; intraoperative graft verification
(This special issue belongs to the Section Cardiovascular Medicine)
Endoscopic Innovations in Gastrointestinal Diseases: From Diagnosis to Therapy
edited by Mattia Brigida and Gianluca Andrisani
submission deadline 20 Feb 2027 | 1 articles | Viewed by 1473 | Submission Open
Keywords: endoscopic innovation; gastrointestinal diseases; advanced endoscopic imaging; therapeutic endoscopy; artificial intelligence; minimally invasive therapy; personalized medicine
(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
Clinical Advances in Endocarditis: From Diagnosis to Treatment
edited by Ram Sharony and Katia Orvin
submission deadline 20 Feb 2027 | 2 articles | Viewed by 1471 | Submission Open
Keywords: endocarditis; infective endocarditis; prosthetic valve endocarditis; TAVR endocarditis; advanced cardiac imaging
(This special issue belongs to the Section Cardiology)
Cardiac Arrest: Beyond Survival—Precision Neuroprognostication After Cardiac Arrest
edited by
submission deadline 20 Feb 2027 | 2 articles | Viewed by 1352 | Submission Open
Keywords: cardiac arrest; outcome; prognostication; targeted temperature management; post-cardiac arrest care
(This special issue belongs to the Section Cardiology)
Contemporary Issues and Emerging Trends in Colorectal Surgery submission deadline 20 Feb 2027 | 1 articles | Viewed by 1330 | Submission Open
Keywords: abdominal surgery; minimally invasive surgery; colorectal surgery; colorectal cancer; inflammatory bowel disease; image-guided surgery; transational research; artificial intelligence; operative endoscopy; screening; early diagnosis; ERAS
(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
Neuroimmunological Disorders: Mechanisms and Therapies submission deadline 20 Feb 2027 | 1 articles | Viewed by 1328 | Submission Open
Keywords: neuroinflammatory; multiple sclerosis; neuromyelitis optica spectrum disorders; mog associated disease; autoimmune/paraneoplastic encephalitis
(This special issue belongs to the Section Clinical Neurology)
Endoscopic Management of Pancreaticobiliary Disease: Updates and Future Directions
edited by
submission deadline 20 Feb 2027 | 3 articles | Viewed by 1257 | Submission Open
Keywords: pancreaticobiliary disease; ERCP; interventional EUS; tissue acquisition; early detection of pancreaticobiliary malignancy; management of AEs
(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
New Clinical Insights into Acute Respiratory Failure submission deadline 20 Feb 2027 | 1 articles | Viewed by 1229 | Submission Open
Keywords: acute respiratory failure; pathophysiology; advances respiratory monitoring; respiratory support strategies; respiratory mechanics; mechanical ventilation; respiratory drive; patient-ventilator asynchrony
(This special issue belongs to the Section Intensive Care)
Novel Insights into the Use of Artificial Intelligence in Clinical Medicine
edited by Sharon C. Kiang and Roger T. Tomihama
submission deadline 20 Feb 2027 | 1 articles | Viewed by 1187 | Submission Open
Keywords: artificial intelligence; disease predictive models; wearable technology; surgical innovation; molecular targeting; big data science; machine learning; deep learning
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