Advances in Rhinosinusitis and Nasal Polyposis: From Emerging Trends and Therapeutic Opportunities to Surgery
A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Otolaryngology".
Deadline for manuscript submissions: 20 June 2026 | Viewed by 511
Special Issue Editors
Interests: endoscopic sinus surgery; sinonasal biologic treatment; rhinosinusitis; nasal polyposis; endoscopic septoplasty
Interests: endoscopic sinus surgery; rhinosinusitis; nasal polyposis; septoplasty
Special Issues, Collections and Topics in MDPI journals
Interests: severe asthma; EGPA; eosinophils; nitric oxide; T cell immunology; chronic rhinosinusitis
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Chronic rhinosinusitis with nasal polyps (CRSwNP) is an inflammatory condition, the most prevalent symptoms of which include nasal obstruction, nasal and postnasal discharge, an abnormal sense of smell, and facial pain. With as much as 4% of the population estimated to be affected, CRSwNP has a significant impact on quality of life and health due to its high direct and indirect cost to both individuals and society. The pathophysiology remains unclear, and a multifactorial interrelation has been observed between genetic, immunological, environmental, and mucoepithelial barrier (microbiota) aspects, which determine the existence of multiple phenotypes and endotypes in chronic rhinosinusitis. In those patients whose symptoms cannot be clinically controlled with appropriate medical therapy, endoscopic sinus surgery (ESS) provides a beneficial alternative treatment. Notably, extensive ESS approaches are associated with favorable surgical outcomes and improved quality of life (QoL), in addition to lower relapse rates. The analysis of different aspects of the appearance of nasal polyps—at both cellular and molecular levels—in addition to different surgical approaches and the outcomes associated with new treatments (monoclonal antibodies) in the context of precision medicine, constitute the current and future routes of study in this field. The accurate selection of uncontrolled relapsing CRSwNP in terms of type-2 endotyping by a multidisciplinary approach can maximize dupilumab efficacy. The number and extent of previous surgeries may differentiate the response, although this effect is difficult to catch in real life. “Adequate” ESS before dupilumab may drive mostly effective disease control. Particular attention should be paid to anatomical variations in the nose and paranasal sinuses, which must be identified radiologically and which could influence the long-term results of biological therapy. If present, surgical treatment may be necessary.
Dr. Gian Luca Fadda
Prof. Dr. Giovanni Cavallo
Dr. Giuseppe Guida
Guest Editors
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Keywords
- nasal polyps
- chronic rhinosinusitis
- asthma
- endoscopic sinus surgery
- anatomical variation
- biologic treatment
- type-2 inflammation
- paranasal sinuses
- CRSwNP
- late response
- long term
- remission
- dupilumab
- control
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