Myopic Optic Neuropathy (MON) and Glaucomatous Optic Neuropathy (GON): Current Concepts and Clinical Implications
A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Ophthalmology".
Deadline for manuscript submissions: 25 June 2026 | Viewed by 2275
Special Issue Editor
Interests: glaucoma surgery; glaucoma imaging; cataract; minimally invasive glaucoma surgery (MIGS)
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
In 1977, axonal transport blockage in glaucomatous eyes was first demonstrated to occur at the lamina cribrosa (LC). Subsequently, in 1981, experimental studies in rabbits, where LC is lacking, revealed axonal transport blockage outside the optic nerve head. Later, in 1985, the axonal transport blockage outside the LC was confirmed in the monkey eye at the edge of Elschnig’s scleral ring. These findings suggest that mechanical stress outside LC, together with axonal damage at deformed myopic LC and associated vascular abnormalities, may explain the unique pattern of myopic optic nerve damage.
The concept of myopic optic neuropathy (MON) is now gaining increasing recognition.
Numerous studies have reported a positive association between myopic deformation of the optic disc, the location or distribution of vessels, and the development or progression of atypical visual field defects. It is well established that glaucomatous eyes with myopia are prone to developing central visual field defects, highlighting the need for early intervention to preserve vision.
Although myopia is a known risk factor for glaucoma onset, the rate of visual field loss in myopic eyes is often not faster than in non-myopic eyes, a paradoxical observation. Previous studies suggest that MON progression is age-dependent, showing rapid progression in young adults but relative stabilization in older age, a pattern that differs from that of GON.
In that case, the benefit of IOP reduction on MON progression remains uncertain.
Extensive IOP reduction in highly myopic eyes may induce hypotony maculopathy or choroidal folds, paradoxically worsening central vision despite surgical success. These risks highlight the need for careful evaluation of optimal surgical strategies for glaucoma associated with myopia.
This Special Issue brings together current insights on myopic and glaucomatous optic neuropathies, aiming to elucidate their pathophysiology and to refine therapeutic approaches.
Dr. Etsuo Chihara
Guest Editor
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Keywords
- myopic optic neuropathy
- glaucomatous optic neuropathy
- tilting
- axonal transport
- lamina cribrosa
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